Lab for RadBio Modeling and Dosimetry for Radiopharmaceutical Therapy at Mass General Hospital & Harvard Medical School
Boston, MA
Joined August 2022
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The B-Lab in Summer 2025 at the Ether Dome @MassGeneral @harvardmed
#science #radonc #radiopharmaceuticals #medphys #biomedeng – at Boston, MA
Bertolet Lab / b-lab retweeted
Are Radiopharmaceutical Therapy Trials Designed to Undertreat? Co-authored by @alebertolet.
Read the full article. bit.ly/4fI3ing
New in @JCO_ASCO (doi.org/10.1200/JCO-26-00796): we traced where the three numbers that shape almost every radiopharmaceutical therapy trial actually came from. 23 Gy to the kidney, 2 Gy to the marrow, 200 mCi per cycle. None came from the drugs they now limit. A thread.
These borrowed limits can push trials to underdose. In one prospective cohort, patients taken up to the kidney limit lived 29 months longer (54 vs 25). Trials can look negative just because they tested too low a dose.
New paper: liver radioembolization is scored by one number, the average dose. But microspheres lodge in vessels too small for CT to see, so the real dose pattern can vary 5-fold even when that average looks identical. bertoletlab.mgh.harvard.edu/…
PAPER: iopscience.iop.org/article/1…
Bertolet Lab / b-lab retweeted
What do radiation therapy and gazpacho have in common? 🍲 🔬
Besides both requiring careful preparation, they are also important parts of the story of Carlos Huesa-Berral, PhD, from @bertoletlab the latest researcher featured in our Researchers Unplugged series!
Learn more here: mgriblog.org/2026/06/25/rese…
Congrats to Dr. @chuesaberral, awarded an NIH/NCI K99/R00 Pathway to Independence Award! 🎉 His project predicts the radiation dose liver tumors receive in Y-90 radioembolization, before treatment, to make the therapy more precise and more curative. #Theranostics #Y90
“Same absorbed dose” can mean very different biology in α-therapy. In our TOPAS-RPT work with ²¹¹At-PARPi, space + time-resolved, cell-by-cell transport shows how targeting shifts LET and damage per Gy. Paper here: doi.org/10.1016/j.ijrobp.202…
About one of our last students, Maëlyne Bennasar, what a pleasure it was to work with her!
linkedin.com/posts/alejandro…
The annual meeting of @aapmHQ is starting today and we have a significant presence as a lab. Please check out the following talks if you're around! #AAPM2025
linkedin.com/posts/alejandro…
