Friday’s MSCI rebalance will be the largest ever, with a ~$303bn overall trade.
Notable tech rebals include: $NVDA (largest trade notionally of ~$11b to sell, net index supply of almost 50mn shares)
$AAPL big large buy ~$3.1b, net demand 10.5m shares)
and $MSFT (big large buy of $2.9b, net demand 7m shares).
$INTC should be net index supply of 31.9m shares
JPM DESK
WELLS DESK
Snowpiercer vibes from Delta these days…
BREAKING: Delta Air Lines will no longer offer free snacks or drinks on all flights starting May 19th (under 350 miles).
Meanwhile, Delta CEO Ed Bastian received $27.1 million in 2024.
Consumers lose, every single time.
Goo retweeted
If you’re a man driving a jeep wrangler with 20+ rubber ducks on your windshield, you shouldn’t have the right to vote.
Goo retweeted
I have openclaw sending lowball offers on Zillow all day just to make boomers start panicking lol
Goo retweeted
“This feels like 1999 again.”
No, it doesn’t. And I was there (here).
I joined Cisco in January 2000 as a co-op, then full-time in May 2001. At the time, Cisco was the hottest infra company on the planet, riding the wave of the dot-com boom.
But by the time I started full-time, the crash had already begun. A month in, my manager was laid off. The party was over. Entire industries vanished.
Here’s what actually happened:
1. The users weren’t ready.
Most people were on dial-up. Mobile didn’t exist. E-commerce logistics were immature or non-existent. Everyone had ideas, but the end user wasn’t there.
2. Capital vanished.
The IPO window shut. Venture funding dried up. Startups that depended on future growth couldn’t raise and died fast.
3. Metrics were fake.
Companies like Kozmo, Webvan, Pets.com burned cash chasing usage that never converted. Things like CAC/LTV wasn't common enough vernacular.
4. Infra got overbuilt.
Telcos like Global Crossing and WorldCom spent billions on fiber and data centers. The demand never showed up. Cisco’s customers disappeared, not because they lost but because their customers died.
5. Business models were broken.
Most dot-coms were never real businesses. They scaled early and hoped revenue would catch up. It didn’t.
Now look at today.
OpenAI, Meta, Google, xAI, Microsoft are all scrambling to keep up. Jensen put it plainly (h/t @BG2Pod)
“Every hyperscaler has realized they dramatically underbuilt.”
“Every forecast we’ve seen has been too low.”
“We’re not building for speculation. We’re building for active workloads.”
So no. This isn’t 1999.
This isn’t Pets.com IPOing on vibes.
We are not in a hype cycle.
We are in a compute bottleneck.
Goo retweeted
.@GileadSciences and Agenus Enter into Collaboration to Develop Immuno-Oncology Therapies agenusbio.com/#.XBuOYnd5c3w.…
Goo retweeted
$AGEN hits 2018 milestones w AGEN1181 (nex-gen CTLA-4) FDA safe to proceed to clinic + IND filed for AGEN1223 (first-in-class intratumoral Treg depleting Bispecific). So far, 5 INDs in 2018 & one more on its way (AGEN1423). #immunoOncology #patientcare
Goo retweeted
New data on lead programs at #ESMO18 including:
- Proprietary #CTLA4 (AGEN1884) & #PD1 (AGEN2034) combination in advanced/refractory solid #tumors, including 2L #CervicalCancer
- PD-1 dose escalation and expansion in 2L cervical cancer. #immunotherapy
bit.ly/2RCwmAT
Goo retweeted
Newsletter, Issue 6, focuses on our partnerships:
-QS-21 enable $GSK vaccines including Shingrix®
-Partnership w/ $MRK delivered First-In-Class Antibody to the Clinic
-Enabled $INCY I-O portfolio w/ 4 clinical stage #Antibodies
-Future partnerships.
Read: bit.ly/2O4maSR
Goo retweeted
There will also be unscrupulous characters who intentionally say wrong or do wrong regardless of the facts.
Goo retweeted
Today’s announcement is the first and the smallest of multiple transactions we expect to conclude this year. Agenus Closes $15 Million Partial Royalty Monetization With XOMA investor.agenusbio.com/2018-…
Goo retweeted
Thank you Chairman Burr, Vice Chairman Warner, and the committee, for the opportunity to speak on behalf of Twitter to the American people. I look forward to our conversation about the work we’re doing to help protect the integrity of US elections, and elections around the world. – at Washington, DC
Goo retweeted
What it takes to deliver INDs at a prolific rate and industry-leading speed?
Learn how $AGEN achieved this by bringing cell-line development and GMP manufacturing, in-house. #Immunotherapy #innovation @Agenus_Bio
4th issue $AGEN #News brief highlights:
How our in-house, state-of-the-art GMP manufacturing (Berkeley, CA) and cell-line development (Cambridge, UK) facilities, enable us to continually deliver #innovation with speed.
#immunotherapy @Agenus_Bio
Read more agenusbio.com/wp-content/upl…
















