@avhoeck
Joined February 2014
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Did you try GPT4? @Lolla0x @xtrapstarr @akash230me @smartsheepdjy @IcedKnife @BCrypto2020 @pradeep9770 @JasonB10659985 @0xzube @bigimot5824 @0973396838_van @wibowoherdi1982 @ChrisGG2017 @0x0xTom
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Crypto users can use GPT4 @mehran_Senator @YBakash @toyballz @YURIAGUNG9874 @GreatGrey3 @SandipC56671777 @Boon41706158 @JaysonFabian5 @RoachCartelnft @13506603wer @plipjan @filippocccc @RifandiZky24 @OliverPayeM
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Excited to share with you the first manuscript of the lab! Here, we describe a novel synthetic lethal interaction between BRCA1-deficiency and EXO1 loss. (1/7) biorxiv.org/content/10.1101/…

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

Deficiency for the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) leads to chromosomal instability and diseases such as cancer. Yet, defective HR also results in vulner...

biorxiv.org
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So glad to see you found a nice environment in Barca to continue your research as PI in cancer genomics. Many congrats!! Looking forward to your future projects with your friends at @HartwigMedical.
Francisco Martínez-Jiménez@fran_mj881 Feb 2023
Thrilled to announce that today I begin a new chapter as Junior Group leader at the @VHIO in Barcelona. My team will work in close collaboration with the @HartwigMedical studying multiple facets of tumorigenesis and its interplay with the immune system 1/4
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𝗛𝗖𝗚 𝗚𝗥𝗔𝗡𝗧𝗛 GIST a window to the world of oncology Systemic use of chemotherapies: study spells out risk of secondary cancer Read at: linkedin.com/pulse/systemic-… @BSAjaikumar_HCG @theRajGore @drvishalrao @reshmalobo @avhoeck @NatureComms @UMCU_Intl @oncodeinstitute

Systemic use of chemotherapies: study spells out risk of secondary cancer

Thanks to genome-wide mutation analysis, we know for a fact that specific anti-cancer drugs are highly mutagenic to cancer cells. Having said that, the mutational impact of anti-cancer therapies on...

linkedin.com
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Anti-cancer therapies are highly mutagenic to cancer cells but the mutational impact on healthy tissues remains elusive. A study in @NatureComms characterises somatic mutations in healthy colon and liver adult stem cells after chemo- or radiotherapy. go.nature.com/3T7QWs9
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If you missed this paper by @ewartkuijk, @ecuppen, and @avhoeck, go check it out! 🔍go.nature.com/3Sl4e3l
Nature Portfolio
@NaturePortfolio18 Oct 2022
Anti-cancer therapies are highly mutagenic to cancer cells but the mutational impact on healthy tissues remains elusive. A study in @NatureComms characterises somatic mutations in healthy colon and liver adult stem cells after chemo- or radiotherapy. go.nature.com/3T7QWs9
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Our study is now also featured on the Editors’ Highlights page -> nature.com/collections/aahaj…

Cancer

On this page we provide a snapshot of some of the most exciting works recently published in Nature Communications in cancer research. We cover all aspects of ...

nature.com
EJ Gibson@avhoeck7 Oct 2022
The mutational impact 🧬of standard chemotherapies 💉💊 in healthy tissue is tissue-type specific!! ⚠️Now online at rdcu.be/cW5vk⚠️ Together with @ewartkuijk and @ecuppen @UMCU_CMM @Cancer_UMCU @oncodeinstitute
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Si bien ls quimioterapias son altamente efectivas xa matar las células cancer osas, su uso sistémico tb aumenta la carga mutacional d las células madre normales responsables d la renovación dl tejido, lo q aumenta el riesgo de desarrollar segundos cánceres doi.org/10.1038/s41467-022-3…
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@ewartkuijk @ecuppen @avhoeck et al. analyse #SomaticMutation patterns induced by anti-cancer #therapies in adult #StemCells from healthy colon and liver using #organoids and #WholeGenomeSequencing #CancerResearch #AdultStemCells @natrescancer go.nature.com/3fPP5tw
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Systemic chemotherapies use increases the mutational burden of long-lived normal stem cells responsible for tissue renewal, thereby increasing the risk of developing second cancers. nature.com/articles/s41467-0…
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Interesting study from @ecuppen & @avhoeck (some surprising, others not so surprising results!) in @NatureComms: Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue nature.com/articles/s41467-0… All adult stem cells (ASCs) or ChemoRx are not the same!
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The mutational impact 🧬of standard chemotherapies 💉💊 in healthy tissue is tissue-type specific!! ⚠️Now online at rdcu.be/cW5vk⚠️ Together with @ewartkuijk and @ecuppen @UMCU_CMM @Cancer_UMCU @oncodeinstitute
Nature Communications@NatureComms7 Oct 2022
@ewartkuijk @ecuppen @avhoeck et al. analyse #SomaticMutation patterns induced by anti-cancer #therapies in adult #StemCells from healthy colon and liver using #organoids and #WholeGenomeSequencing #CancerResearch #AdultStemCells @natrescancer go.nature.com/3fPP5tw
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Novel insights on the mutational impact of DNA hypomethylation. Great study from @ewartkuijk
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⚠️⚠️Amazing paper alert⚠️⚠️ Machine learning-based classification of tissue of origin for cancers of unknown primary based on whole-genome features. >90% sensitivity and specificity and highly informative feature explanation. Take a look at the tweetorial and the manuscript👇👇
Luan Nguyen@luannnguyen014 Jul 2022
Our paper titled “Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features” is now online in @NatureComms! @avhoeck @ecuppen nature.com/articles/s41467-0… Check out the tweetorial below:
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Our work on CUP detection now online. CUPLR, developed by @luannnguyen0, detects prim tumor type from WGS data. WGS-based DNA tests with CUPLR will improve diagnostics for cancer patients whose primary tumor is unknown, which is reimbursed in 🇳🇱 for these patients. @ecuppen-lab
Luan Nguyen@luannnguyen014 Jul 2022
Our paper titled “Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features” is now online in @NatureComms! @avhoeck @ecuppen nature.com/articles/s41467-0… Check out the tweetorial below:
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CUPLR was developed within @Cancer_UMCU, @UMCU_CMM and @oncodeinstitute with financial support from #hanarthfonds.
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The metastatic cohort data is via the Hartwig database (see Dr. @ecuppen tweetorial linked below). An incredible freely available resource for the cancer research community.
Edwin Cuppen@ecuppen16 Feb 2022
Pleased to announce our novel catalog interface of the Hartwig database with whole genome sequenced tumor genomes: catalog.hartwigmedicalfounda…. Currently more than 5,000 patients, including treatment and response data. Plus RNA-seq data for more than half of the patients.
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Exciting new preprint exploring genomic differences between early stage primary tumors and late stage metastatic tumors across cancer types @fran_mj88 @avhoeck @ecuppen biorxiv.org/content/10.1101/…
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Our latest now online! with @fran_mj88 (🇪🇸) Ali (🇮🇷) Sascha (🇨🇭) @luannnguyen0 (🇻🇳) and @ecuppen (🇳🇱) @Cancer_UMCU @UMCU_CMM @HartwigMedical @oncodeinstitute
Francisco Martínez-Jiménez@fran_mj8820 Jun 2022
How genomically different are early stage primary tumors and late stage metastatic tumors? Check out our latest work “Pan-cancer whole genome comparison of primary and metastatic solid tumors'' 🧬💻. Main findings and conclusions 🧵👇 biorxiv.org/content/10.1101/…

Pan-cancer whole genome comparison of primary and metastatic solid tumors

Metastatic cancer remains almost inevitably a lethal disease. A better understanding of disease progression and response to therapies therefore remains of utmost importance. Here, we characterize the...

biorxiv.org
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