@auerglass

Pathologist. Camera shy but people friendly at distance of 6 ft or more. #StayHome #PPENow #Masks4All #Vote Tweets/opinions/views my own.

Joined March 2019
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A little exposition about reticulin & the #specialstain of the same name. It is a stromal structural protein, usually present as a meshwork, i.e. a reticular pattern, from which its name derives. Reticulin is composed of collagen III, glycoproteins & glycosaminoglycans. 1/11
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They redesigned PubMed, a beloved website. It hasn’t gone over well sciencemag.org/news/2020/05/…
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If you are worried about "optimizing" but not sleeping 7 to 9 hours per night start there. During sleep: -Your body gets physically stronger. -Your mind processes, stores, and connects information. -You increase emotional control. Sleep. The best performance enhancer there is.
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how to understand the validity and biases of a source: - research its reputation and credibility - research its record for accuracy and controversy - research its funding and associations - research its editorial and vetting processes - research its audience and critics
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Every Monday for the past 4 weeks, we have been sending our projections to the CDC. So far, covid19-projections.com has been the most accurate model every week. In last week's CDC projections, we projected 88,767 deaths on May 16. On May 16, the US reported 88,751 deaths (1/7)
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Here is what it would look like if people started social distancing one week later. We'd have 160k more deaths by May 14 and ~270k more deaths by August. covid19-projections.com/us-1…
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I ran my model to see how the US would fare if everyone began social distancing one week earlier. I estimate there would be 51k fewer deaths by today and likely 125k fewer deaths by August. Interestingly, this exactly matches the 51k estimate provided by @washingtonpost.
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WATCH: High school seniors form virtual orchestra to sing national anthem during 'Graduate Together' event
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60y/o man with absolute lymphocytosis (25K/uL). #FlowCytometry is performed on PB. What is your suspected diagnosis? What additional data and/or markers would request? Images courtesy of Dr. @sindhucherian @UWFlow @UW Stay tuned for follow up & answers! #FlowEdu #hmepath
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We updated every state's reopening timeline to reflect the current situation as of May 1. This may cause a "second wave" of cases for states such as Georgia and Colorado. We are the only model that factors in state-by-state reopenings. Full projections: covid19-projections.com
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“Megamitosis” , caught in the act. Megakaryocytes undergo endomitosis, they divide the nuclei but not the cytoplasm, as a result mature megs have 64n DNA content (unlike most cells in the body, which have 2n DNA )
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We can compare #COVID19 1% infection fatality rate with an expected >80% attack rate (R0 of ~3) to seasonal influenza with 0.1% IFR and yearly attack rate of ~10%. Simple math would put unmitigated spread as >80X worse than a typical flu season. xitter.cf/trvrb/status/125339832…
Trevor Bedford
@trvrb23 Apr 2020
Thoughts on seroprevalence in NYC. I'm not at all surprised by an estimate of 21% seropositive in NYC as discussed by @NYGovCuomo today (xitter.cf/NYGovCuomo/status/1253…). 1/6
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1/7 Lots of folks trying to understand sensitivity and specificity. Maybe the most important concept to understand right now is that of POSITIVE PREDICTIVE VALUE. Given a test result is positive, what are the chances you were actually infected? Biostats 101 primer on the topic.
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A full listing of ICCS educational resources can be viewed at the following link: cytometry.org/Resource-Cente…
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This study shows that most COVID-19 transmission occurred indoors. This is to be expected since outdoor activities were severely restricted during much of the study period. Outdoor activities are likely safer, but we don't know how much safer, because there is no denominator.
Scott Gottlieb, MD 🇺🇸
@ScottGottliebMD23 Apr 2020
New: Study of 318 outbreaks in China found transmission occurred out-of-doors in only one, involving just 2 cases. Most occurred in home or public transport. Raises key chance for states to move services outdoors (religious, gym classes, restaurants, etc). medrxiv.org/content/10.1101/…
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1. It's easier to poke holes in a study than to run a study yourself. We should expect many more SARS-CoV-2 serosurveys in our future. So in the spirit of promoting good science, here are my thoughts on best practices for the design of serosurveys.
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“Two semi-trailer trucks, cleverly marked as food-service vehicles, met us at the warehouse. When fully loaded, the trucks would take two distinct routes back to Massachusetts to minimize the chances that their contents would be detained or redirected.” #COVID19

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Introverts crave connection too. Social interaction energizes all of us—some of us are just more easily overloaded by it. Introverts don't seek solitude. We want to be in touch without being overstimulated. Video calls optional, please! #FridayThoughts nytimes.com/2020/04/16/smart…

Yes, Even Introverts Can Be Lonely Right Now (Published 2020)

Introverts crave connection, too — we just need more boundaries.

nytimes.com
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Very interesting new preprint by Eran Bendavid and colleagues reports seroprevalence estimates from Santa Clara county. Great to have seroprevalence work start to emerge, but I'd be skeptical of the 2-4% seroprevalence result. 1/8 medrxiv.org/content/10.1101/…

COVID-19 Antibody Seroprevalence in Santa Clara County, California

Background Addressing COVID-19 is a pressing health and social concern. To date, many epidemic projections and policies addressing COVID-19 have been designed without seroprevalence data to inform...

medrxiv.org
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Common flow cytometry pitfalls in diagnostic hematopathology onlinelibrary.wiley.com/doi/…
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