Loved catching up with Dr Nasha Winters. We discussed what happens when you intentionally suppress ketogenesis, the current modern lifestyle intervention. This results in insulin-compensated euglycaemia (ICE), due to surpassing one’s own personalised hyperinsulinemia threshold (PIT). Understanding how to detect if someone is in the ICE-PIT allows for earlier intervention where things are easier to turn around. The PIT protocol to detect ICE: measure your evening pre-dinner at least three hrs fasted, glucose and ketones, for at least 7 days but optimally at least 21 days. If ketones are consistently <0.5 mM then you are in a metabolic endocrine phenotype of ICE and surpassed your PIT. If your GKI is above 4 consistently, you are in the ICE-PIT metabolic-endocrine phenotype range. If sustained over time, this has been shown to be associated with mitochondrial dysfunction which tracks with the development of chronic diseases and poorer ageing. Increasing insulin demand and exposure in the body has a significant negative effect on blood biomarkers associated with chronic disease and mitochondrial dysregulation. youtu.be/Ju9GefNeGuU