@appleton_caleb
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Cyclist, coffee roaster, recovering triathlete and engineer. Deep tech investor at Bison Ventures. Always learning. Views are my own.
San Francisco, CA
Joined August 2017
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FULL INTERVIEW: Andrei Georgescu's company Vivodyne is growing human tissue to test drugs without testing people.
He explains why 19/20 drugs fail, how human tissue could replace animal testing, and what this technology could mean for personalized medicine.
01:45 The breakthrough that made large-scale human tissue possible
05:40 Why animal testing fails to translate to humans
07:30 The ethical limits of growing human tissue
09:00 The FDA is pushing alternatives to animal testing
09:40 Using human tissue for personalized medicine
10:00 Growing thousands of copies of a patient’s tissue
Today @vivodyne unveils their Human Data Center capable of producing more true human data than all of the world's clinical trials combined.
AI will transform human health, but only if we have the ability to generate, perturb and reason on real human data at scale.
AI has created a 21st-century hyperabundance of potential new drugs and biological hypotheses, but we are still using 18th-century style animal testing.
Instead, @Vivodyne is evaluating drugs in living human tissues at industrial scale.
Excited to continue working with Vivodyne as they iterate on their 'Virtual Human' data center, where we can predict treatment response.
Caleb Appleton retweeted
We're launching Sleuth today.
The intelligence platform for biopharma's highest-stakes decisions, in use at top companies in the world.
To celebrate, we broke down the Chinese landscape: 18K+ assets & a map of the strategic white space. RT + comment "Sleuth" for access.
Caleb Appleton retweeted
🥁 October Featured Investor: @appleton_caleb, @BisonVentures Caleb’s led investments in techbio & AI (@Vivodyne, @Cobot) and shares how a key career moment shaped his VC approach: evca.org/blog/caleb-appleton
Caleb Appleton retweeted
Dropped by Georgia Tech to remind the Yellow Jackets to register to vote!
iwillvote.com
Caleb Appleton retweeted
In 2022, less than 2% of app downloads converted to paying subscribers
But that's not how the top subscription apps perform
We found out what success looks like and published our findings in our State of Subscription Apps report
These are the highlights 🧵
Caleb Appleton retweeted
These notes nicely compliment our previous efforts such as:
ML Notebooks: github.com/dair-ai/ML-Notebo…
ML Notes: github.com/dair-ai/ML-Course…
Somehow it’s Election Day and democracy is in peril, yet all people on the bird app care about is a middling crypto exchange that sponsored some NBA teams
Caleb Appleton retweeted
👀 This just in: GT Engineering still good at Engineering 🙌
– 2 programs at #⃣1⃣: @GeorgiaTechISyE, @GTaerospace
– ALL 10 programs in the top 5⃣
– And overall, our undergraduate engineering program remains #⃣4⃣ in the nation in today's new @usnews rankings. A good way to start the week! b.gatech.edu/3DbpDZ1
ALT Top of Tech Tower with text: #4 undergraduate engineering program in the nation. All engineering programs ranked in the top five (US News & World Report rankings, 2023 edition)
Caleb Appleton retweeted
My Garmin reads 113 degrees. With smoke blowing into Idaho from the seemingly continuous California fires, the air quality index is almost double the temperature. A brown haze obscures the landscape.
theradavist.com/good-grief-a…
EPL now on TuneIn - download the app or ask your Alexa to "Listen to the Arsenal Game"
Big news: The #EnglishPremierLeague is now on TuneIn! Listen to every match, from every team, all season long. Ready to hit the pitch? Check it out here: listen.tunein.com/eplsocial
Caleb Appleton retweeted
Big news: The #EnglishPremierLeague is now on TuneIn! Listen to every match, from every team, all season long. Ready to hit the pitch? Check it out here: listen.tunein.com/eplsocial
Currently entering hour 1.5 hours waiting for our room @theautocamp
- have been told at least one more. Meh. Instagram certainly ≠ real life
Fly @united where you have the pleasure of paying Delta prices for Spirit service. Currently waiting on the ground for 1 hour staring at my gate as my connecting flight boards
I sure hope the Dems have someone good in mind in West Virginia. I realize it is incredibly risky but I'm done living in a world where a Senator from a state of 1.7M is the deciding voice on every meaningful issue. America. I'll gladly donate to a primary challenger. (1 of 3)
I'm not letting the GOP off the hook here (they are certainly the problem) but there was a clear path to ensuring a commission happened and we couldn't find the gumption within our own party. Unfortunately this has been true for 6 months now (2 of 3)