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The collaboration between @VariantBio and @novonordisk will trigger our long term benefit sharing program for the first time! Read about it in the NYT. nytimes.com/2025/01/07/healt…
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Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis @Nature from Tetsuji Kakutani & colleagues - beautiful insights into control of transposon insertion into the centromeres
nature.com/articles/s41586-0…
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New blog: Modified Base Best Practices & Benchmarking for @nanopore 🧬 sequencing Includes:
* Raw POD5 files for synthetic ground truth strands
* Modified base calling best practices
* Modkit recommendations
Check it out: labs.epi2me.io/mod-validatio… #methylation #bioinformatics
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.@nanopore today announced that @RosemaryDokos has been appointed Chief Product & Marketing Officer & Lakmal Jayasinghe as Chief Scientific Officer, effective immediately. Rosemary & Lakmal succeeded Clive Brown as Chief Officer of Technology, Innovation, & Products. Read more: bit.ly/3O4ulvQ
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It is my absolute pleasure to share my incredible postdoc Dawei's @amaizeingcorn manuscript on epigenetics and aging in Arabidopsis. It is the work I am most proud of thus far in my career, and every figure has a breakthrough that we are excited about
biorxiv.org/cgi/content/shor…
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Super exciting to see what the future holds for nanopore beyond DNA and RNA sequencing nature.com/articles/s41586-0…
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This paper led by Dr. Atsushi Shimada is out @NaturePlants! Centromere function can be dependent on a few TEs, and in RNAi mutants, small RNAs targetting these TEs are enough to reestablish normal chromosome segregation! Crazy! nature.com/articles/s41477-0…
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So great to see this paper out in @Nature. Beautiful molecular characterization of a new toxin-antidote drive system in maize, led by Ben berube, with assistance from Martienssen lab @antnerves @CrisAlves_bio @BioJlynn and collaborators @arminscheben @jrossibarra Jerry Kermicle
Why was corn able to spread and adapt so rapidly across the Americas 4,000 years ago? Research from CSHL’s Rob Martienssen suggests that the answer may lie in a genetic system called Teosinte Pollen Drive. cshl.edu/corns-missing-link/
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I'm thrilled to share that I'll be joining @Yale as an Assistant Professor in the Department of Molecular, Cell, and Developmental Biology @MCDB_Yale in January 2025! (1/3)
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H3K4me1 recruits DNA repair proteins in plants academic.oup.com/plcell/arti… interesting findings! @Grey_Monroe @ThePlantCell
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Friends, we are introducing LiftOn, a homology-based genome annotator that uses a protein-centric algorithm, considering both DNA & protein alignments to improve genome annotation lift-over 1/9
@StevenSalzberg1 @elapertea @JakobHeinz9 @alaina_shumate @celinehohzm @alan_mayonnaise – at Baltimore, MD
Combining DNA and protein alignments to improve genome annotation with LiftOn biorxiv.org/cgi/content/shor… #biorxiv_bioinfo
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A hallmark of sex is each parent transmits half of their genome through a recombined egg or sperm. What if this was not the case? Check our new paper @NatureGenet where we break this rule via diploid clonal gametes and develop polyploid genome design
nature.com/articles/s41588-0…
ALT A SEM micrograph of a clonal tomato pollen grain made by a MiMe plant
ALT A diagram with the text "No meiotic recombination, sister chromatid cohesion or meiosis II leads to clonal gametes"
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The MaizeCODE paper is on BioRXiv! New insights on enhancers in plants and a lot of data for every maize (epi)geneticist to play with, including on teosinte, the ancestor of maize. A big team effort, very grateful to everyone involved!
biorxiv.org/content/10.1101/…
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First major work fully made in the laboratory is out in @biorxivpreprint: biorxiv.org/content/10.1101/…. We found that DNA methylation allows recurrent endogenization of giant virus in a protist🦠 closely related to animals, large scale virus and eukaryotic host genomic mixture.🧵 1/10
antnerves retweeted
Really thankful to start the year in such a great way: Our paper is out today! 🥳 Congrats to all the authors for their hard work, and thanks to the editors & reviewers for their insight on how to improve it! 🧵1/3 nature.com/articles/s41477-0…
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Gene expression involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. We developed ChIP-DIP – a method for simultaneous, genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. biorxiv.org/content/10.1101/…
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Join our department! Please share to potential candidates
We invite you to become our colleague: Technician for Plant Molecular Biology at @RIBESresearch, please share and RT. ru.nl/en/working-at/job-oppo…
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My PhD research on Arabidopsis mC readers is finally out in @biorxivpreprint. It took a long time, a lot of work, and there are still many open questions, but thanks to @JamesPBLloyd @ry_lister and great collaborators it's out there!
biorxiv.org/content/10.1101/…
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It is out in @NewPhyt! Happy to share my review on the genetics of paralog compensation to overcome the redundancy barrier in functional studies. nph.onlinelibrary.wiley.com/…
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What causes cancer? Medical science has been grappling with this for centuries. Today, thanks to a genome-editing technique invented at CSHL, cancer research could come full circle, leading to better outcomes for cancer patients.
cshl.edu/genome-hack-reignit…
