@antle718

Wallenberg & SciLifeLab DDLS fellow precision medicine. Assistant Professor Linköping University. Comp bio, single-cell omics, tumour evolution.

 Sweden
Joined May 2018
  • Tweets205
  • Following155
  • Followers133
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A lot of hard work has gone into making this robust and reliable, must read for anyone working with RNA. Amazing effort by @JCMolBio @BReinius and our team.
Björn Reinius@BReinius30 Sep 2024
Excited to have published our work on #SEQURNA, a next-generation RNase inhibitor transforming #scRNAseq & other applications. ➡️Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq 🚀 🌕 nature.com/articles/s41467-0… 🧵…
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Antonio Lentini retweeted
Sequrna@sequrna26 Apr 2025
Coming Soon! #SEQURNA™ introduces #SEQblock™ tube modules. Temperature uniformity and cleaner tube handling for your RNA workflows. Launching soon in 96-PCR, 384-PCR, 24-MCT, 48/12-PCR/MCT, & 15-MCT midi format. Tell us what formats & features you seek!
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Antonio Lentini retweeted
Sequrna@sequrna14 Apr 2025
#SEQURNA Synthetic Thermostable RNase Inhibitor for #scRNAseq protects RNA at high temperatures, enabling new protocols. Dry-ice-free shipping improves #RNAseq sustainability🍀 R&D by @BReinius @sandberglab @JCMolBio @antle718 🌐 sequrna.com 🧬 nature.com/articles/s41467-0…
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Andrew Kern@pastramimachine11 Dec 2024
Octopus Z dosage compensation! biorxiv.org/content/10.1101/…

Z-chromosome dosage compensation and a male-specific lncRNA in octopus

Sex chromosomes typically present as two copies of a large, gene-rich differentiated chromosome in the homogametic sex (e.g. XX in female mammals, ZZ in male birds) but as a single copy in the...

biorxiv.org
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Great work @nataliepapanic!
Björn Reinius@BReinius11 Dec 2024
Replying to @BReinius
Work spearheaded by PhD candidate Natalie Papanicolaou (@nataliepapanic). Check it out: biorxiv.org/content/10.1101/… #Xist #RNA #chromosome #XCI
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Antonio Lentini retweeted
Björn Reinius@BReinius14 Nov 2024
Thrilled about the launch of #SEQURNA RNase Inhibitor Thermostable in Genovis' new Genomics Branch, boosting RNA-seq with superior stability & sustainability. Discover more and join @GENOVIS in Advancing Next-Gen Genomics Tools! 🌟🔬 genovis.com/genomics/
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JCMolBio@JCMolBio13 Feb 2024
We have rigorously tested the next-generation of RNase inhibitors - thermostable, robust, and resistant to batch effects - for single cell RNA sequencing and I am so excited that this pre-print is finally out! There is more information at sequrna.com
Single Cell papers@scell_papers7 Feb 2024
Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq dlvr.it/T2RDSq
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Our paper on Notch signalling pathway activation by soluble and multivalent Jag1 DNA origami nanopatterns is out at @NatureComms @bjorn_hogberg @teixeiralabki @vcluca1 rdcu.be/dyfDo
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Introducing the next generation of RNase inhibitors in scRNA-seq! 🔥 Thermostable ⏱️ Improved performance 🌿 Environmentally friendly Happy to share our work at SEQURNA AB in this preprint showcasing the technology. Huge thanks to team and beta testers. biorxiv.org/content/10.1101/…

Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq

Single-cell RNA-sequencing (scRNAseq) is revolutionizing biomedicine, propelled by advances in methodology, ease of use, and cost reduction of library preparation. Over the past decade, there have...

biorxiv.org
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Today out @NatureNeuro Estrogen sensitive neurons control stress sensitivity in females and aversive state. What a beautiful journey, together @fuzikjanos @Pierre_Le_Merre @meletislab @CarlenLab. So proud of this work! #CuriosityDrivenScience nature.com/articles/s41593-0…

Esr1+ hypothalamic-habenula neurons shape aversive states

Nature Neuroscience - The authors find a surprising diversity in hypothalamic neurons projecting to habenula, and using patch-sequencing (Patch-seq), identify an estrogen receptor-expressing neuron...

nature.com
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What can we infer from equations with 2 unknowns? We explore this for concurrent X-chromosome upregulation/inactivation, raising doubts on recent findings that X-upregulation is limited to a few genes and driven by BRD4. With @BReinius. authors.elsevier.com/c/1h7L9…
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Work funded by @ssmfgrants, @KAWstiftelsen, @Vetenskapsradet and @karolinskainst.
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Check out our latest work on #Omicron variants featured on the cover of @MedCellPress. With ABC Labs and @BReinius (who also made the cover). Research made possible thanks to @KAWstiftelsen, @scilifelab, @stiftelse, @Vetenskapsradet. doi.org/10.1016/j.medj.2022.…
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Also see news article from @karolinskainst: news.ki.se/single-clinical-t…

Single clinical test provides more answers about COVID-19

Researchers at Karolinska Institutet in Sweden present the results of a refined clinical COVID-19 test, which has been used to track the spread of the Omicron variant in real time in the Swedish...

news.ki.se
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Antonio Lentini retweeted
Eric Topol
@EricTopol8 Aug 2022
New @MedCellPress From ~175,000 samples in Sweden, a 2-fold higher viral RNA levels in upper airway for BA.2 relative to BA.1 cases, that helps explain its heightened transmissibility cell.com/med/fulltext/S2666-… by @BReinius and colleagues (would be good to see such data for BA.5)
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Björn Reinius@BReinius12 Aug 2022
"Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 cases" in @MedCellPress with @antle718. cell.com/med/fulltext/S2666-… Research made possible by @KAWstiftelsen @scilifelab @stiftelse @Vetenskapsradet

Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals...

The SARS-CoV-2 pandemic has been characterized by waves of novel mutated virus variants. Lentini et al. tracked the ongoing Omicron emergence in the Swedish population in real time, showing how...

cell.com
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A KI study in @MedCellPress by @breinius and @antle718 presents a refined #COVID-19 test used to track the spread of #Omicron in real time. news.ki.se/single-clinical-t…
Illustration by Getty Images

ALT Illustration by Getty Images

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So excited to see our ✨🧬'Molecular spikes'🧬✨ RNA spike-ins out in @naturemethods 📃 Since the preprint, we have completely overhauled the design & produced a completely new expanded set of spikes, so check it out: nature.com/articles/s41592-0… more below...⬇️

Molecular spikes: a gold standard for single-cell RNA counting

Nature Methods - This work presents an RNA spike-in that can be used to improve RNA counting in single-cell RNA-sequencing (scRNA-seq) analysis, as well as to report the performance of scRNA-seq...

nature.com
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Antonio Lentini retweeted
Alon Keinan@AlonKeinan14 Apr 2022
Elastic dosage compensation by X-chromosome upregulation, by @antle718 et al. w/@BReinius from @karolinskainst Another fascinating chapter on #ChrX #DosageCompensation @NatureComms #OpenAccess nature.com/articles/s41467-0…

Elastic dosage compensation by X-chromosome upregulation

Nature Communications - The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood. Using allelic...

nature.com
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Elastic dosage compensation by X-chromosome upregulation nature.com/articles/s41467-0… @antle718 @BReinius @karolinskainst @KAWstiftelsen @ssmfgrants #DosageCompensation #Xinactivation #Xupregulation #scRNAseq

Elastic dosage compensation by X-chromosome upregulation

Nature Communications - The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood. Using allelic...

nature.com
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