The 400’s in Rome were brutal

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Boring Company’s goal is to solve traffic in cities and one day build Hyperloop high-speed transit between city centers

BREASTMILK She thought she was studying milk. What she uncovered was a conversation. In 2008, evolutionary anthropologist Katie Hinde was working in a primate research lab in California, analyzing breast milk from rhesus macaque mothers. She had hundreds of samples and thousands of data points. Everything looked ordinary—until one pattern refused to go away. Mothers raising sons produced milk richer in fat and protein. Mothers raising daughters produced a larger volume with different nutrient balances. It was consistent. Repeatable. And deeply uncomfortable for the scientific consensus. Colleagues suggested error. Noise. Statistical coincidence. But Katie trusted the data. And the data pointed to a radical idea. Milk is not just nutrition. It is information. For decades, biology treated breast milk as simple fuel. Calories in. Growth out. But if milk were only calories, why would it change depending on the sex of the baby? Katie kept digging. Across more than 250 mothers and over 700 sampling events, the story grew more complex. Younger, first-time mothers produced milk with fewer calories but significantly higher levels of cortisol—the stress hormone. The babies who drank it grew faster. They were also more alert, more cautious, more anxious. Milk wasn’t just building bodies. It was shaping behavior. Then came the discovery that changed everything. When a baby nurses, microscopic amounts of saliva flow back into the breast. That saliva carries biological signals about the infant’s immune system. If the baby is getting sick, the mother’s body detects it. Within hours, the milk changes. White blood cells surge. Macrophages multiply. Targeted antibodies appear. When the baby recovers, the milk returns to baseline. This was not coincidence. It was call and response. A biological dialogue refined over millions of years. Invisible—until someone thought to listen. As Katie reviewed existing research, she noticed something unsettling. There were twice as many scientific studies on erectile dysfunction as on breast milk composition. The first food every human consumes. The substance that shaped our species. Largely ignored. So she did something bold. She launched a blog with a deliberately provocative name: Mammals Suck Milk. It exploded. Over a million readers in its first year. Parents. Doctors. Scientists. People asking questions research had skipped. The discoveries kept coming. Milk changes by time of day. Foremilk differs from hindmilk. Human milk contains over 200 oligosaccharides babies can’t digest—because they exist to feed beneficial gut bacteria. Every mother’s milk is biologically unique. In 2017, Katie brought this work to a TED stage. In 2020, it reached a global audience through Netflix’s Babies. Today, at Arizona State University’s Comparative Lactation Lab, she continues reshaping how medicine understands infant development, neonatal care, formula design, and public health. The implications are staggering. Milk has been evolving for more than 200 million years—longer than dinosaurs walked the Earth. What we once dismissed as simple nourishment is one of the most sophisticated communication systems biology has ever produced. Katie Hinde didn’t just study milk. She revealed that nourishment is intelligence. A living, responsive system shaping who we become before we ever speak. All because one scientist refused to accept that half the story was “measurement error.” Sometimes the biggest revolutions begin by listening to what everyone else ignores.

Excellent study on correlates of protection for nuvaxovid / novavax. Higher IgG and nAb levels are excellent predictors for risk of any and severe infection. Helpful data on durability as well. 🧵

The Bigger Short

The IgG4 class switch phenomenon in particular is a major reason why not only young people, but also older adults should consider Novavax instead. The mRNA vaccine modality had its place early on, but this finding makes it not sustainable in the long term. immunityageing.biomedcentral…

The more you get sick, the faster you age. Therefore, any intervention that protects you from getting sick as often is an anti-aging device.

I always get this question a lot, when Novavax inevitably rolls out right after a significant summer wave: To be clear, as long as you’re feeling okay without any acute illness symptoms, you can get your Novavax booster as soon as you want following a COVID infection (or any viral illness). There’s no inherent need to wait. It’s actually a good thing for you to get it sooner, since we know that Novavax is beneficial for helping your immune system fight the persistent virus that is left behind by an infection. For some reason, it’s become popular in the COVID-conscious community to parrot government recommendations of waiting anywhere from 3 and 6 months following an infection. I have absolutely no idea why folks feel compelled to do that, but it’s no different from the original herd immunity and “vax & relax” strategies. Those recommendations only begin to make any sort of sense if you have an assumption of robust infection-induced immunity that simply doesn’t match up with reality. And they were aimed at providing people with as much convenience as they could possibly muster. And like I said, they also require the assumption that viral persistence isn’t an issue (which is wrong) or that Novavax isn’t likely to provide any benefits in fighting it (which is wrong). If you’re getting Novavax following a dose of mRNA, then there’s a recommendation to wait for 2 months. Which is based on CDC eligibility guidelines, and also avoids elevating the extremely small myocarditis risk above baseline.

@elonmusk @POTUS @VP @SecKennedy @RWMaloneMD @RobertKennedyJr @NIHDirector_Jay @VPrasadMDMPH @FDA I always knew. So many ppl know now. Why wont Robert Fauci Kennedy ban mrna? @CamillusLellis @The43rdcaptain @PaulHan43252703 @anne_nova2 @NewXvg @iyunjeong27132 @entropy143661

"We're finalizing the design of Optimus v3. It will have essentially the manual dexterity of a human, a very complex hand and an AI mind that can navigate and comprehend reality. Optimus will be the biggest product ever." 一 Elon Musk