I'm excited to get to work with this wonderful group of scientists to build community, organize conferences and centralize links to resources in brain body research!
Thrilled to help launch the NIH Blueprint Coordination Center for Interoception Research (BPCCIR) with @KhalsaLab (UCLA), @ruimcosta (Allen Institute), @andermann_mark (Harvard/BIDMC) & @lab_xin
(UCSF), and our broader team. We will build a collaborative community and advance the science of brain–body communication. Appreciate the NIH's vision for interoception science.
Rachel Essner deserves huge congrats for this opus on integrative brain-to-body signaling in the parabrachial nucelus. Now improved and published! Check it out.
I’m thrilled to share the published version of our paper, now officially out in Neuron! Read it here: authors.elsevier.com/c/1no8J…
One updated highlight: with new analyses we now show how functionally-defined groups of neurons putatively overlap with molecular cell types in LPBN
Peter Kalugin's paper on optical tracking of up to ten neuromodulators simultaneously is out in Neuron with some cool new results, including quantitative demixing of norepinephrine and dopamine concentrations. Please check it out and retweet!
MORSE is out now in Neuron, with an expanded dataset: sciencedirect.com/science/ar…
Using crosstalk to our advantage, we demixed norepinephrine & dopamine's binding at each other’s sensors to simultaneously quantify their release from locus coeruleus with resolution in the tens of nM.
Our lab is hoping to hire a long-term lab manager / research associate to help with admin tasks and neuroscience experiments (3-year minimum commitment). Please RT! bilh.wd1.myworkdayjobs.com/E…
@markandermann.bsky.social retweeted
NEW: Mark Andermann (@andermann_mark) of @harvardmed and @BIDMChealth brings experimental data and computational modeling together to understand cortical reactivations. Watch the video:
youtu.be/1N6i7Zi9kXs
#NeuroAI2025 #neuroscience #AI #NeuroAI
We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet.
Nice work, Marta & team!
🚨Paper alert!
📣 We found abnormal feeding-related neural responses in satiety-promoting, MC4R-expressing neurons in the mouse paraventricular hypothalamus (PVHM-C4R) following diet-induced obesity. biorxiv.org/content/10.1101/… #obesity #feedingbehaviour #obesityresearch
A drop of milkshake takes a wild ride after it is swallowed. Rachel and Kiersten came up with cool strategies for visualizing food passing through the mouse GI tract and mapping the activity of the same 100s of brainstem neurons across weeks during feeding and other behaviors.
I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. biorxiv.org/content/10.1101/…
@markandermann.bsky.social retweeted
I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. biorxiv.org/content/10.1101/…
@markandermann.bsky.social retweeted
[1/4] Registration for our two-day virtual & in-person symposium in June is now open! See below for the full list of cutting-edge experts in #neuroscience and #AI speakers:
Stand Up for Science rally, March 7, 12-4 pm, Boston Common. Better than moping.
eventbrite.com/e/stand-up-fo…
We lack tools to track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope (MORSE).
I’m thrilled to share our preprint presenting MORSE: a new way to simultaneously and quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope.
biorxiv.org/content/10.1101/…
Come explore emerging research in brain-body communication @KeystoneSymp Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInteroception25 #KSInteroception25 pic.x.com/gWsgQgcAJh
@markandermann.bsky.social retweeted
I am thrilled and grateful to share that I’ll be starting my lab at @ISTAustria in June 2025! We will study how the hypothalamus maintains homeostasis in response to challenges. Check out our website: dmhlab.org, and if interested please get in touch!
In other words, perhaps we should consider slowing down and savoring each moment.
@markandermann.bsky.social retweeted
I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3
We found that in vivo peptide release and signaling gradually enhances the response of satiety-promoting hypothalamic neurons to each bite of food during a meal. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety.
I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3
Pretty exciting result: disrupting cue reactivations in mouse visual cortex in the hours *after* operant training completely blocks learning.
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See scholarship, abstract and discount reg dates: keysym.us/KSInteroception25 #KSInteroception25
@markandermann.bsky.social retweeted
Our perspective on the frontiers of neuroscience beyond the nervous system. Thank you, @CellCellPress, for the opportunity to collaborate with our partners @NadineGogolla and @SLiberles. Thanks Chi Jingyi and Popescu, Miranda. My special thanks to Megan Sammons.
How our brain and body talk to each other, with control of inflammation and our immune response
cell.com/cell/fulltext/S0092… @CellCellPress
@rolls_asya @NadineGogolla @PopescuMiranda @SLiberles and colleagues, open-access
