@alexstein_

Postdoc (mathematical biology, somatic evolution, cancer genomics)

 London
alexander-stein.me/
Joined September 2013
  • Tweets178
  • Following417
  • Followers233
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Our new paper "Selective sweep probabilities in spatially expanding populations" is out in Nature Communications! Our work extends the theory of population genetics and contributes to our understanding of cancer evolution. doi.org/10.1038/s41467-026-6…
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Steven Strogatz
@stevenstrogatzSep 8
Here's Tristan Buckmaster's statement. (You've probably seen bits of it quoted here today, but the whole thing is worth reading.) cims.nyu.edu/~tristanb/state…
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nature
@NatureApr 2
Nature research paper: Gene regulatory landscape dissected by single-cell four-omics sequencing go.nature.com/4sPbIPg

Gene regulatory landscape dissected by single-cell four-omics sequencing

Nature - Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of...

nature.com
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You can find a summary of the paper in this blog post: mathematical-oncology.org/bl…
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And if you are curious about the story of the paper from conception to publication, there is a blog post about the "behind the scenes" here: communities.springernature.c…

On the expansion and evolution of a master’s project

Academics often lament that hardly any master’s projects – even the best ones – get published. The student moves on. Other research takes priority. No one has time to do the final analyses. Here I...

communities.springernature.com
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Alexander Stein retweeted
Jeffrey West
@mathoncbroMar 5
This week in MathOnco 362 growth dynamics, adaptive therapy, PINNs, resistance dynamics, chemotaxis, and more. Art: Robert Noble thisweekmathonco.substack.co…
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Carlo Maley@cmaleyFeb 3
We are excited to announce a new clinical trial - adaptive therapy for metastatic ER+ breast cancer at Mayo Clinic AZ (NCT06525766). Adaptive therapy manages the evolution of the cancer to extend survival time and reduce toxicity (improve quality of life). bit.ly/4cehaWe

Adaptive Therapy With Capecitabine For Treatment Of Metastatic ER Positive, HER2 Negative Breast...

Learn more about services at Mayo Clinic.

mayo.edu
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In #GENETICS, @alexstein_ and @BenjaminWerner_ present a new study about the population genetics of cancer. Learn about their theoretical assessment of the genetic makeup of cancers before and after treatment: buff.ly/cADPpiP
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Our manuscript on the patterns of genetic heterogeneity before and after treatment is finally out! doi.org/10.1093/genetics/iya…

On the patterns of genetic intra-tumor heterogeneity before and after treatment

Abstract. Genetic intra-tumor heterogeneity is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumulation,

academic.oup.com
Alexander Stein@alexstein_14 Oct 2024
New manuscript with @BenjaminWerner_ online on bioRxiv!! 📑Our manuscript provides a theoretical investigation of genetic intra-tumour heterogeneity before and after treatment. biorxiv.org/content/10.1101/…

On the patterns of genetic intra-tumour heterogeneity before and after treatment

Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumulation and selection with important implications for...

biorxiv.org
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EvoGamesPlus@EvoGamesPlus11 Dec 2024
After intense research discussions, day 2 wrapped up with an alternative Prague tour exploring underground gems!🚇🎨 EvoGamesPlus researchers learned about graffiti culture, discovered new art spaces, visited a cryptobar, and ended the night in a steampunk club. What a ride!🔥
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EvoGamesPlus@EvoGamesPlus9 Dec 2024
Wrapping up the early stage researcher talks on day 1 of the conference, we had insightful presentations from Christo Morison, @alexstein_, @Redondo96, and @Thomas_Marcou! 🌟👏 #EvoGamesPlus
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🚨 We're Hiring! 🚨 @TPMTUDelft at @tudelft is seeking an #AssistantProfessor in Computational #Modeling for #Health. Apply by January 10, 2025, and join us in shaping the future of #healthcare! Learn more and apply via lnkd.in/empB7sGR!

LinkedIn

This link will take you to a page that’s not on LinkedIn

lnkd.in
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PhD Position AI-driven Nanoparticle Design for Drug Delivery academictransfer.com/347208/ @TUDelft

PhD Position AI-driven Nanoparticle Design for Drug Delivery

Join our pioneering PhD project to transform brain-targeted drug delivery through advanced AI and machine learning for nanoparticle design! Job description As part of the European Horizon project...

academictransfer.com
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King L Hung@kinglhung6 Nov 2024
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. Today we report in @Nature that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ nature.com/articles/s41586-0…

Coordinated inheritance of extrachromosomal DNAs in cancer cells

Nature - Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.

nature.com
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Imran Noorani@drimrannoorani26 Oct 2024
Very pleased to share our new online pre-print! We explore the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in human glioblastoma. biorxiv.org/content/10.1101/…. A 🧵

Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma

Oncogene amplification on extrachromosomal DNA (ecDNA) is strongly associated with treatment resistance and shorter survival for patients with cancer, including patients with glioblastoma. The...

biorxiv.org
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WeiniHuang@huang_weini21 Oct 2024
Finally online: Accumulating waves of random mutations before fixation with Marius Moeller and @BenjaminWerner_ . journals.aps.org/pre/abstrac…

Accumulating waves of random mutations before fixation

Mutations provide variation for evolution to emerge. A quantitative analysis of how mutations arising in single individuals expand and possibly fixate in a population is essential for studying...

journals.aps.org
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New manuscript with @BenjaminWerner_ online on bioRxiv!! 📑Our manuscript provides a theoretical investigation of genetic intra-tumour heterogeneity before and after treatment. biorxiv.org/content/10.1101/…

On the patterns of genetic intra-tumour heterogeneity before and after treatment

Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumulation and selection with important implications for...

biorxiv.org
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more replies
Upon emergence of resistance, we find that the frequency of the largest resistant clone is subdominant and independent of the population size at detection, whereas the relative total number of resistant cells increases with detection size.
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I'm really happy to have this work in a state that is sharable to the public! I hope the manuscript brings joy to the readers and helps them understand genetic heterogeneity a little better.
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