@ale__samma

DVM, PhD. Study Director | Preclinical Toxicologist at Merck Healthcare KGaA

 Italy
Joined January 2021
  • Tweets25
  • Following278
  • Followers56
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Alessandro Sammarco retweeted
EANO@EANOassociation20 Oct 2024
👏Congratulations to our #EANO2024 award winners for Best Poster Presentation: Sophie Bockel (Clinical research), Alicia Buck (Basic research), Alessandro Sammarco (Translational research), Cressida Lorimer (Supportive care & quality of life research)! #NeuroOncology #btsm
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Alessandro Sammarco retweeted
BADRlab@BadRlab17 Oct 2024
Off to Glasgow for #EANO2024. Excited to present some of our work on lipid metabolism in #braintumors. Also proud of @ale__samma , who was selected to present his work on breast cancer brain metastasis during the Poster Pitches Session @EANOassociation @MGH_RI @MGHNeurology
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Excited to share our latest work where we tested the effect of a brain-penetrant clinical-stage inhibitor of fatty acid desaturation on cancer and immune cells in breast cancer brain metastasis mouse models. @BadRlab @katharinaeyme biorxiv.org/content/10.1101/…

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast...

Breast cancer brain metastases (BCBM) are a significant cause of mortality and are incurable. Thus, identifying BCBM targets that reduce morbidity and mortality is critical. BCBM upregulate Stearoy...

biorxiv.org
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These findings suggest that SCD inhibition could be an effective strategy to intrinsically reduce tumor growth and reprogram anti-tumor immunity in the brain microenvironment to treat BCBM.
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Replying to @ale__samma @BadRlab @katharinaeyme
Pharmacological inhibition of SCD decreased engagement of immunosuppressive pathways, including the PD-1:PD-L1/PD-L2 and PVR/TIGIT axes in the tumor microenvironment.
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Replying to @ale__samma @BadRlab @katharinaeyme
Inhibition of SCD enhanced antigen presentation by dendritic cells, was associated with a higher interferon signaling, increased the infiltration of cytotoxic T cells, and decreased the proportion of exhausted T cells and regulatory T cells in the tumor microenvironment.
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Replying to @ale__samma @BadRlab @katharinaeyme
Combined targeting of SCD and PARP prolonged survival of mice with breast cancer brain metastases.
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Replying to @ale__samma @BadRlab @katharinaeyme
Pharmacological inhibition of SCD markedly reshaped the lipidome of breast cancer cells and resulted in endoplasmic reticulum stress, DNA damage, loss of DNA damage repair, and cytotoxicity.
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I've decided to join the TEXAS MS 150, a fundraising 150-mile bike ride that changes the world for people affected by Multiple Sclerosis. If you'd like to donate, in the first comment you'll find a link to my fundraising webpage. Thank you for your support!
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events.nationalmssociety.org…

I'm supporting the National MS Society!

The National MS Society's vision is a world free of MS. The Society mobilizes people and resources so that everyone affected by MS can live their best lives as we stop MS in its tracks, restore what...

events.nationalmssociety.org
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Alessandro Sammarco retweeted
NathansonLab@NathansonLab25 May 2023
#GBM are lethal, molecularly heterogeneous tumors – it was unknown whether this molecular diversity led to distinct phenotypes and metabolic lipidomic vulnerabilities. New, open access @Cancer_Cell paper: sciencedirect.com/science/ar…
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Alessandro Sammarco retweeted
BADRlab@BadRlab8 Feb 2023
It is so exciting to see our work highlighted in @NatRevDrugDisc Drugging a metabolic vulnerability in glioblastoma nature.com/articles/d41573-0…
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A compound that targets de novo lipid synthesis in #GliomaStemCells shrinks #glioblastoma tumors in mice, potentiates DNA-damaging agents, and can penetrate the blood-brain barrier.  Read more: scim.ag/1eG @katharinaeyme @BadRlab @ale_samma
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We are so thrilled to see our work published in @ScienceTM on a new therapeutic strategy that inhibits de novo lipid synthesis to treat glioblastoma. Thanks to @BadRlab, @katharinaeyme and co-authors. Also, many thanks to @AICF_nyc for their support.
BADRlab@BadRlab18 Jan 2023
Very excited to share our latest work now out in @ScienceTM on targeting #lipidmetabolism in #glioblastoma Great team effort led by @katharinaeyme @ale__samma with other past/present lab members and our collaborators at @Yumanitytx and @UCLA 🧵👇 science.org/doi/10.1126/scit…

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblast...

A clinical-grade inhibitor of SCD delays tumor growth and increases sensitivity to DNA-damaging agents in GBM preclinical mouse models.

science.org
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Here is our latest work on #lipidmetabolism in #glioblastoma. Fascinating results on what drives sensitivity and resistance to fatty acid inhibitors in glioblastoma. @BadRlab @katharinaeyme biorxiv.org/content/10.1101/…

Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid...

Deregulated de novo lipid synthesis (DNLS) is a potential druggable vulnerability in Glioblastoma (GBM), a highly lethal and incurable cancer. Yet the molecular mechanisms that determine susceptibi...

biorxiv.org
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Alessandro Sammarco retweeted
BADRlab@BadRlab17 Nov 2021
Attending SNO? check out work from our group led by the outstanding @katharinaeyme EXTH-23 - Preclinical efficacy of a targeted, brain penetrant inhibitor of fatty acid desaturation in glioblastoma cdmcd.co/q9Wgqg #sno2021 #BTSM
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Alessandro Sammarco retweeted
BADRlab@BadRlab18 Oct 2021
We are looking for a research techI/II to join our group @MGHNeurology @harvardmed @MGH_RI. If you are interested in brain tumor research feel free to reach out. #MedTwitter #AcademicTwitter More info 👇
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Alessandro Sammarco retweeted
UCLA
@UCLA13 Sep 2021
👑 #1 public university 🐻 5 years in a row! 💙 🎉 💛 #1UCLA ucla.in/3txsPqP
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Alessandro Sammarco retweeted
BADRlab@BadRlab23 Jun 2021
We have an open post-doc position for a newly funded project in our lab. If you are interested in studying stress signaling and lipid metabolism in brain tumors let's talk. More details👇👇 partners.taleo.net/careersec… #MedTwitter #AcademicTwitter @MGHNeurology @harvardmed @MGH_RI
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Alessandro Sammarco retweeted
CDC
@CDCgov13 May 2021
UPDATE: If you are fully vaccinated against #COVID19, you can resume activities without wearing a mask or staying 6 feet apart, except where required by federal, state, local, tribal or territorial laws, incl. local business and workplace guidance. More: bit.ly/3btJaFU
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