Biochemist with interst in lipids, glycans, proteins and their regulation... husband and father of two @ahulsmeier@mstdn.science @ahulsmeier.bsky.social

Zurich, Switzerland
Joined January 2015
Andreas Hülsmeier retweeted
A study using an n=1 experiment with single standards at 0V CID reported that 70% of detected ions were in-source fragments (ISFs). nature.com/articles/s42... This was extrapolated to suggest that ISFs affect all experiments to this degree. A counterpoint. rdcu.be/ebFwc
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Glycosphingolipids in neurodegeneration? 🧠 Lipids may hold the key to understanding Alzheimer's, Parkinson's, and beyond. Discover how glycosphingolipids influence neurodegeneration and explore their potential as therapeutic targets in this latest review. sciencedirect.com/science/ar…
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Andreas Hülsmeier retweeted
Thank you @shaha_kash and @KhalifaUni UAE for the invitation. We had a great conference.
Dr @MuseerSphinx delivering a Keynote on “Decoding the sphingolipid enigma: bridging neurodegeneration, metabolism, and therapeutic frontiers” at the 3rd UAE Anatomy & Cellular Biology Conference #acbc held at @KhalifaUni
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Andreas Hülsmeier retweeted
Paper out: Gene encoded nanoparticles (GEMs) with 180 GFPs are cool tools to track in cells. GEMs reveal biophysical basis of infection, too. Using GPI-anchored nanobody receptors over 6 logs of affinity shows that adhesion energy alone explains uptake! rdcu.be/dFddO
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Andreas Hülsmeier retweeted
New genes and mutations that cause childood form of ALS. Our collaborative efforts bearing fruit. Thank you @JNNP_BMJ and all the collaborators. #ALS #sphingolipids #rarediseases
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis jnnp.bmj.com/content/early/2… @MuseerSphinx
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Andreas Hülsmeier retweeted
In 1948, Swiss pharmacologist Peter Witt embarked on a noteworthy investigation concerning the impact of drugs on spiders. His study involved a series of experiments wherein he administered drugs to the spiders through two distinct methods: either by feeding them flies that were drugged or by providing them with a small amount of a drug dissolved in water. To assess the effects, Witt captured photographs of the spiders' webs both before and after the administration of the drugs. The subsequent findings are presented below.
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Andreas Hülsmeier retweeted
Lipid Space Tool is here! It is a stand-alone tool to analyze and compare lipidomes by assessing their structural differences. More: lifs-tools.org/lipidspace.ht…
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Andreas Hülsmeier retweeted
It’s the most wonderful #glycotime of the year! Let us (@ElisaTelisa @Ojas_Singh_) introduce you to #GlycoShape (glycoshape.org), a web platform that allows users to restore glycoproteins 3D structures (PDB, AF/RoseTTAFold or own) to their natural, functional state by adding the missing glycan structures doi.org/10.1101/2023.12.11.5… 🧵1/8
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Andreas Hülsmeier retweeted
Reviewers don't get paid, but maybe they could get tips?
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The importance of validating antibody performance elifesciences.org/reviewed-p…
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Andreas Hülsmeier retweeted
Lipid structure matters in lysosomal storage disease sciencedirect.com/science/ar…
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It's almost four weeks since the horrific terrorist attack on #Israel. A lot has happened, the public debate has become heated and confused. Find thoughts from Vice-Chancellor Robert #Habeck in the video, putting the events in context. 📣With English, Hebrew and Arabic subtitles.
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Andreas Hülsmeier retweeted
You have heard of the periodic table of elements- we present the Periodic Table of Monosaccharides, where we attempt to arrange the monosaccharides in a systematic table. Published in Glycobiology: academic.oup.com/glycob/adva… #glycotime #glycoeducation #glycans #monosaccharides
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A great thanks to our dedicated co-authors for their invaluable collaboration in making this story possible. The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy - Journal of Lipid Research jlr.org/article/S0022-2275(2…
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