Adam Ghobarah retweeted
Demand for DeepSeek V4.1 Flash has been nuts. People have agents grinding on it all weekend, nonstop.
So screw it, we're cutting the price 51% 🚀🚀. keep them running.
Adam Ghobarah retweeted
From Wet Lab to RL Env: 10,000 Drug-Discovery Campaigns in a Weekend
@LeashBio’s @allmeasures explains how DNA-encoded libraries generate billions of protein–molecule measurements, why no team in Leash’s Kaggle competition beat chance on an unseen chemical library, how public datasets can teach AI to recognize the chemist instead of understand the chemistry, why engineering protein mutations exposes model memorization, and how replayable experimental worlds let agents run over 10,000 medicinal chemistry campaigns in a weekend. Plus: Hermes vs. Boltz, moving from DEL hits to mouse studies in six months, and why experimental rigor and the Bitter Lesson of scaling could unlock a new generation of AI-driven drug discovery.
Adam Ghobarah retweeted
Gemini 4 Argon achieves SOTA on real robot capabilities, tied with Opus 5.5 and above GPT-6 Astra. 🧵
Adam Ghobarah retweeted
There's so much more on this in our preprint and blog post. Please check them out!
github.com/Leash-Labs/minos-…
leashbio.substack.com/p/maki…
/fin
Adam Ghobarah retweeted
Agentic models can act, observe consequences, and decide what to do next.
This is great for coding, but if you want them to do science, lab experiments take forever.
To fix this, we made a lab-in-the-loop with zero latency!
1/10
Adam Ghobarah retweeted
Or, build a cluster and own the hardware, make your money go way further, still have a valuable asset after 3-5 years, and make a differentiated model bet. That's what humans& did
Huge thanks to @DeepInfra and to @nvidia @Supermicro for working with us to make it happen
The economics of a Neolab.
A neolab is loosely defined as a startup of AI researchers who raises a lot of money pre-production to be able to finance GPU compute to take on a large AI problem.
To buy 1000 GB300s or ~14 NVL72 racks will set you back $125-150M for 3yrs with 15-30% upfront. That’s about ~2-2.5MW.
Thats about enough to do 10^25 flops a quarter and get to a GPT-4 level model which is 1-2 OOMs off frontier for pretraining.
If you post-train on a great open source model, you have a better chance of getting to frontier. The risks are a) you need to spend millions on RL environments too and b) being lapped by another model release while being tied to a base model.
For this to payback, you need to give your customers a better and ideally cheaper inference service than a base model and serve them for long enough to recoup your large investment. Even at 50% margin on inference, to recoup $10M in training means serving ~10T tokens (!) if you price like Fable / Astra given a standard cache read / input / output split ($2/M blended). And you have to justify being better than a release like Opus 5.5 which is even cheaper. Often, you end up charging your customers a huge premium in terms of platform fees and compute fees on top of pure inference.
Meanwhile, every hour you’re not utilizing your GPUs you are burning money so you typically resell this compute back to a broker or run inference for open models / resell spot instances. At below a ~60% utilization on spot, you will still lose money.
Add to that insane cost of talent.
So what can you do with the compute?
- Not play the model game at all.
- Play an entirely different model game (Jev, World Labs) that if big labs played, would either a) cannibalize their business or b) be incrementally not significant revenue c) would cause too much distraction from the main main thing
- Acquire a proprietary data set (Peridodic Labs) in enough volume in a domain of usefulness to eclipse frontier quality. Often happens in robotics, biology, chemistry.
If you do overcome the challenge of building a model that is useful and well priced beyond big labs models, given the huge price of compute, you still need to play in an area where the revenue / compute ratio is signficant and market demand is large enough to payback your compute spend.
It is a difficult game.
Adam Ghobarah retweeted
3 months in a row, @Scenario_gg made more money than it spent.
To borrow @albn's word, we’re now “immortal”.
So tomorrow I'm taking 10 days off with the family, first time in many, many years. No model launch, no Seedance 2.5, no nothing. 🥹
Then back to crushing the rest of 2026 :) Thanks for following along. We're just getting started :)
------
From @albn's book "Sketchfab, a Startup Memoir" on hitting the same milestone 👇
After 3 years of this - 3 years of gongs and dashboards and police departments and the grinding work of turning a community into a business - we reached the month where revenue exceeded expenses.
Breakeven.
It felt like the end of a siege. For the first time since (...) the very first line of code, we didn’t need anyone’s money to survive.
Not investors, not acquirers, not bridge rounds. We had built a machine that sustained itself. We were, in the language I started using around the office, immortal.
Adam Ghobarah retweeted
There are a lot of things wrong with this world…
but too much intelligence is not one of them.
Adam Ghobarah retweeted
To work and coexist and thrive with humans, AI needs to understand us. This is our work along the way.
Adam Ghobarah retweeted
For AI to work with us, it needs to understand us
Today, we're introducing Persimmon, the first large-scale model designed to realistically simulate how people talk and interact
My new post "The Best AI Founders Will Overcome These 5 Challenges"
linkedin.com/pulse/best-ai-f…
Adam Ghobarah retweeted
🎉 The #opensource #FiftyOne project crossed 1M+ downloads! Thank you to everyone who is using FiftyOne in your #computervision workflows! If you haven’t yet tried it out, head on over to GitHub:
hubs.ly/Q01K2fym0
#machinelearning #datascience #artificialintelligence #ai
Adam Ghobarah retweeted
5/
- Examples of FMs trained on proprietary, domain-specific data like BloombergGPT arxiv.org/abs/2303.17564 show the way forward: enterprises (and people!) using the durable moat of their own private data to build powerful, domain-specific FMs.
Adam Ghobarah retweeted
2/ *Closed APIs aren't defensible*
- Recent examples like @StanfordCRFM Alpaca tinyurl.com/yc78bnct shows that cloning closed API-based FMs like ChatGPT can be done for a few $100 on top of small OSS base FMs (e.g. here, fine-tuning LLaMa 7B via exs from the ChatGPT API).
Adam Ghobarah retweeted
Did you know ... #FiftyOne 0.20 shipped with two new integrations, #Pinecone and #Qdrant, making it easy to use #vectorsearch capabilities natively in FiftyOne to accelerate your #computervision workflows? Learn more:
hubs.ly/Q01JZDWH0
#machinelearning #datascience #ai
Adam Ghobarah retweeted
I've just posted my first update since joining Sourcegraph six months ago, "Cheating is All You Need". In it I introduce AI-backed coding assistants, which are the biggest change I've seen in 35 years as an engineer. Enjoy! about.sourcegraph.com/blog/c…
Adam Ghobarah retweeted
📣 #FiftyOne 0.20 is out!
🚀 Natural language search
🚀 #Qdrant & #Pinecone integrations
🚀 Upgraded support for #pointcloud datasets
🚀 New ways to create, customize & edit similarity indexes
hubs.ly/Q01HR83r0
#computervision #oss #vectorsearch #naturallanguage #ai #ml
Adam Ghobarah retweeted
Learn how to quickly and easily visualize and explore high-resolution media files, like satellite imagery and photo-realistic AI-generated data, with the #opensource #FiftyOne #computervision toolset:
hubs.ly/Q01HLL-P0
#machinelearning #machinevision #datascience #ai
Adam Ghobarah retweeted
A bit of a peek into the PaLM LLM APIs we announced yesterday (currently in private preview with a few customers/users to get feedback: we'll broaden access in the coming weeks)
This Post is from an account that no longer exists. Learn more
Adam Ghobarah retweeted
Computer vision plays a role in every industry. Learn how the #manufacturing industry is using #computervision for automation, safety, precision & more:
voxel51.com/blog/how-compute…
#manufacturingautomation #roboticprocessautomation #machinevision #machinelearning #ai



















