Postdoctoral Research Fellow studying lymph node and spatial biology in @Lo_Zanzi lab @BostonChildrens @harvardmed | PhD '24 @uconnhealth with @PENGHUAWANG1
Boston, MA
Joined October 2020
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Hot off the press!! Had a blast writing this review with @Lo_Zanzi. Here we discuss how stromal cells orchestrate the spatial positioning and immune responses in the lymph node!
#EveryCellIsAnImmuneCell! 💥#NewPaperAlert💥 Excited to share our latest review with @agharrison6 about molecular, cellular & #spatial control of the immune response regulated by #stromal, #innate, & #adaptive immune cells in the lymph node! Free link👉 sciencedirect.com/science/ar…
Congrats @madisonstrine !!!!
Thrilled to share that our post-doc @madisonstrine received the @BWFUND postdoc enrichment funds bwfund.org/grants/diversity-… @YaleMed @YaleIBIO @YalePediatrics
Andrew Harrison retweeted
Thrilled to share that our post-doc @madisonstrine received the @BWFUND postdoc enrichment funds bwfund.org/grants/diversity-… @YaleMed @YaleIBIO @YalePediatrics
And another one! @kjena21 @Lo_Zanzi and et al. demonstrate the power of #fungal PAMPs in boosting adaptive immune processes! Congratulations to the team!
Delighted to share our latest work published in @NatImmunol, demonstrating that antifungal PRR signaling, leveraged through the glycan-based adjuvant Mannadjuvant (MA), can profoundly enhance the breadth and durability of vaccine induced immunity.
nature.com/articles/s41590-0…
Andrew Harrison retweeted
Delighted to share our latest work published in @NatImmunol, demonstrating that antifungal PRR signaling, leveraged through the glycan-based adjuvant Mannadjuvant (MA), can profoundly enhance the breadth and durability of vaccine induced immunity.
nature.com/articles/s41590-0…
Andrew Harrison retweeted
So excited to share our new work beautifully lead by @madisonstrine where we identify new properties of early life T cells. doi.org/10.64898/2026.05.08.…. @YaleMed @YaleIBIO @YalePediatrics
Andrew Harrison retweeted
#EveryCellIsAnImmuneCell! 💥#NewPaperAlert💥 Excited to share our latest review with @agharrison6 about molecular, cellular & #spatial control of the immune response regulated by #stromal, #innate, & #adaptive immune cells in the lymph node! Free link👉 sciencedirect.com/science/ar…
Andrew Harrison retweeted
We work hard. Sometimes we win, others we don’t. The fun part is always the journey, & the excitement that comes when the pieces of the puzzle finally get together revealing unknown aspects of the #ImmuneSystem! Yesterday we celebrated some of our accomplishments! #LoveMyLab
More recently, Michaela Gack group in @CellCellPress revealed the same is true for RLRs! Thus, we explored these ideas and specifically whether GLUT4 relocalizes RLRs to the cell boundary during translocation to the surface
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cell.com/cell/fulltext/S0092…
Thanks to Jon Bogan for GLUT4 expertise! @DuomengYang for his immense help during revision & my PhD. Thank you to all our collaborators, co-authors, reviewers + editors at @NatImmunol for improving the work, friends&family.
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Also, thx to @takarginov, @RathinamVA, @KailasanVanaja , @VinnieViruses, @connorc110, @madisonstrine, Tingting Geng,Jason Cahoon. And many thx to my post doc mentor @Lo_Zanzi for giving me time to finish this out! Look forward to exploring all things innate immunity w/ you!
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However, using several different approaches, we found lactate and even glucose uptake was not involved in regulating RLRs!!
so...how was GLUT4 attenuating antiviral immunity?
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Elegant work from @katbarnett3 and @jkagan1 in @CellCellPress showed that cGAS is positioned at the plasma membrane by interacting with Phosphoinositides, revealing compartmentalization mechanisms also apply to cytosolic sensors.
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cell.com/cell/fulltext/S0092…
Recently, several groups including Hui-Kuan Lin from @DukeMedSchool and Shi Liu (among many others) found glycolytic metabolites (lactate) intersect with RLRs to regulate signal transduction and antiviral immunity.
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sciencedirect.com/science/ar…
nature.com/articles/s41467-0…
Therefore, we attempted to bridge these 4 concepts together: 1) UBXNs, 2) GLUT4, 3) lactate and 4) RLRs. Surprisingly, UBXN9 promoted RLR signaling, whereas the opposite was true when GLUT4 was targeted.
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Happy to share the final chapter of my PhD @uconnhealth out today in @NatImmunol ! Here we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes #metabolism #Immunology @NaturePortfolio
nature.com/articles/s41590-0…
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This project stemmed from previous work in @PENGHUAWANG1 lab investigating UBXNs that regulate innate immunity. Also, Jonathan Bogan @YaleMed discovered one UBXN (TUG, UBXN9) sequesters GLUT4 intracellularly in muscle/fat.
journals.aai.org/jimmunol/ar…
nature.com/articles/nature01…
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