Many diseases could be cured in 10 years. The best candidates are the diseases that either have good biomarkers or good disease models. The right way to cure those diseases is to aggressively screen for disease-modifying perturbations. We should do dose-response trials in healthy human volunteers for antibodies against all receptors, for mRNA LNPs and siRNAs for all transcription factors, and for all endogenous peptides, do a highly multiplexed biomarker readout on the output (physiology+behavior), and we would find a lot of new ways to modulate human physiology that would lead to new cures for diseases. This would probably require ~5 million healthy volunteers and more manufacturing capacity than currently exists on the planet, but it is doable in principle, and probably costs ~$100B. For diseases that have good disease models, you can do the same thing straight in the disease model. In parallel, we can supercharge our efforts to find good biomarkers. We should be doing scalable blood proteomics from existing biobanks. We should also be doing genomics+blood proteomics+behavioral monitoring from extremely large cohorts of patients. We should also be screening ligands (e.g. in consented decedent patients) to identify tissue- or cell-type-specific delivery mechanisms for all major tissues/cell-types in the body. There will still be many diseases that do not have any easily measurable biomarkers and no good animal models, and that will therefore be refractory to cures. Those diseases will need to be solved in the old fashioned way, by hard iterative science that will take time, simply because it takes time to move atoms in the world. Nonetheless, I am extremely optimistic that a huge fraction of human disease burden could be relieved in 10 years, if we started on a major project like this today. Given the amount of time and money it would take to actually get started on this kind of a program, I think 15 or maybe 20 is perhaps more realistic. But it is going to happen.