@acftbl
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Post-doc at @SingMolSci and @UNSWRNA, UNSW | Cell biology, molecular pharmacology | https://nitter.cf/t.co/i28YUzDbA1
Sydney, New South Wales
Joined November 2017
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We're excited to share this work! Have had a lot of fun trying to tackle this problem & some surprising results along the way.
What happens when you suddenly remove half of an essential enzyme from cells? 🤔
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
Pretty happy to share this work on RNA polymerase II!
We had a lot of fun studying this seemingly quite fundamental component of the system controlling Pol II levels & transcription. Amazing to get to work closely with Ana's group on this, combining imaging with genomics.
📢 New paper from the lab!
In a fantastic new collaboration with @ana_tufegdzic lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta @caciopporobi, Alex @acftbl, Ivan @IvanShlamovitz, and Andrew.
cell.com/molecular-cell/full…
fascinating and ambitious work. @tobinatthelab Do you have any further data on the apparent selectivity over M2/3? It would be good to see HTL9936 tested in an additional assay to pERK, tested for antagonism, or some competition affinity measurements.
Potential treatment for memory loss in AD - amazing to work with colleagues @UofGlasgow and @soseiheptaresco - production made slight error in title - being corrected - but the message is clear @UofGIMCSB @UofGMVLS @UofGARC @UoG_TransPharm
authors.elsevier.com/a/1e866…
Reminder to join your union wherever ever you work. There’s a lot that is crook about modern unis but pressure from organised labour protects workers. I am one (hopefully of many) beneficiary of this campaign against historical underpayment.
NTEU members knew USyd had a chronic underpayments issue. Without the activism of NTEU members, USyd would have been able to sweep this under the rug. Now workers will be paid what they're owed. nteu.org.au/join to help your fellow members stop wage theft! #highered
With the publication of this interesting paper (and our associated commentary), I thought I would go through some elements of the broader discussion to highlight some work we were unable to cite.
nature.com/articles/s41386-0…
As we discuss in our commentary, there is clearly a complex and yet to be understood series of mechanisms leading to both opioid tolerance and somatic withdrawal.
doi.org/10.1038/s41386-021-0…
“When I asked him how I should write about his life, he pulled out of his desk a list of every graduate student, postdoc and visitor at his laboratory”
We should all look up to someone who saw the politics in science and the science in politics.
nature.com/articles/d41586-0…