@abt_lab

Microbiology lab at @CAMBUPenn. We study gut-microbiota interactions in the context of infectious disease. Recruiting at all levels! Student-run account.

 Philadelphia
abtlab.med.upenn.edu
Joined July 2019
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  • Following149
  • Followers505
15Media
So happy to congratulate Dr. Kevin Mears, who defended his thesis yesterday! Kevin received an NIH-NIAID F31 fellowship and had a 1st author publication in Cell Reports ( sciencedirect.com/science/ar… )during his time in lab
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The Abt lab has a Research Technician position opening this Summer. We are seeking an energetic graduating senior interested in immunity and microbiome research. Applicants can go to Careers @ Penn (JR00101259) to find out more!
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Check out this fantastic new article by the Zackular lab. Great work! @joeyzacks , @MgAlameh and team. A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection | Science science.org/doi/10.1126/scie…

A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection

Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine...

science.org
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Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism dlvr.it/T78Dpl

Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimul...

Norman et al. use mouse models of C. difficile vaccination and infection to delineate a CXCR4-dependent mechanism by which the secreted toxin TcdB2 suppresses germinal center formation and antibody...

cell.com
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Monoclonal antibody-mediated neutralization of Clostridioides difficil... sciencedirect.com/science/ar…
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Happy to share this pre-print from out lab. This work was lead by Dr. Joshua Denny, a very talented postdoc, in collaboration with Linda Lieberman from Merck Discovery Immunology
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By neutralizing toxin and assessing the innate immune response to C diff infection we shed more light on protective vs pathogenic inflammatory host responses.
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Prokaryotic Seminar 🦠 next Monday! 2/6/2024 From 4-5 PM at 209 Johnson Pavilion, join Subham Mridha, PhD from the @abt_lab!
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Highlighting our lab’s Research Specialist, Ellie @ellsnellz, who was featured in an article about volunteering in the community on MLK day. Great work! whyy.org/articles/fairmount-…

Clearing invasive species in Fairmount Park is just one of dozens of MLK Day volunteer projects

Hundreds of volunteers throughout the region cleared trash, delivered food and rallied for peace and justice as part of the nation’s largest and oldest MLK Day of Service.

whyy.org
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Congratulations to DR. @Emily_Cribas for defending her thesis today. Emily was the first student to join the lab and took a chance with a young PI. So happy for her.
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Congratulations Dr. @YingYang0204! , who defended her thesis earlier today and gave a beautiful talk on development of Th17 memory in the lung.
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Ever wonder what would happen to your immune system if you were stuck with a baby's microbiome? To find out see our new publication in Cell Host and Microbe! authors.elsevier.com/a/1gqSm…
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Super excited to share my and Xinyun Zhang's work published in @MucosalImmunol. We found bacteria-specific memory Th17 cells were still protective even in the context of influenza virus infection. Thank you @abt_lab for all your support! doi.org/10.1016/j.mucimm.202…
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Congratulations to Katelyn Bustin and @MegaMatthewsLab on their paper in @FrontPharmacol. It was great to be part of this project and learn some cool chemistry!
Matthews Group@MegaMatthewsLab
26 Jan 2023
Big congratulations to our PhD student Katelyn Bustin, whose work was published on @FrontPharmacol. Check out this paper about our amazing hydrazine probes for characterizing metabolic drivers of Clostridioides difficile infection! frontiersin.org/articles/10.…

Frontiers | Characterizing metabolic drivers of Clostridioides difficile infection with activity-...

Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regula...

frontiersin.org
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The Abt lab has a Research Technician position opening this Summer. We are seeking an energetic graduating senior interested in immunity and microbiome research. Applicants can go to Careers @ Penn (JR00066297) to find out more!
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New Research: Immunological consequences of microbiome-based therapeutics: The complex network of microscopic organisms living on and within humans, collectively referred to as the microbiome, produce wide array of biologically active… frontiersin.org/articles/10.… #immunology
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Thrilled to share my work from the @joeyzacks lab published today in @nature. We find that enterococci enhance C. difficile fitness and virulence by remodeling the metabolic environment in the gut. Thread below with highlights. nature.com/articles/s41586-0…
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Check out this fantastic work from the Zackular lab! Congrats @joeyzacks and @brokaryote!
Joe Zackular@joeyzacks
16 Nov 2022
Really excited to share our labs first paper published today in @Nature. This work was led by the amazingly talented @Brokaryote, who found that enterococci enhance C. diff fitness and pathogenesis by metabolically remodeling the gut during infection. nature.com/articles/s41586-0…

Enterococci enhance Clostridioides difficile pathogenesis

Nature - Enterococci enhance the fitness and pathogenesis of Clostridioides difficile in the gut by altering the amino acid composition and providing signals that increase its virulence towards the...

nature.com
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If someone from #PennIGGRetreat needs a proof of attendance… assuming that Day 2 afternoon hike led by @abt_lab counts… @IGGPenn @simplyseble et al (tag yourself in comments) @SkytopLodge
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