Dave Blake, PhD (@_stah) profile picture

Dave Blake, PhD

@_stah

Check me out at bsky. OMHIWDMB.

 Augusta GA
augusta.edu/mcg/dnrm/faculty/blakelab.php
Joined January 2011
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Anyone organizing a search should NOT use traditional methods until they read the book "An Inclusive Academy". It has reasons to alter standard practices.
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This is wildly incorrect. PrEP for hiv prevention is 95%+ effective. Please remove this dangerous misinformation.
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But the evidence more than a month after recovery is rather scant. One study shows increased risk (40-50%) from one month after recovery until 12 months. They did not time stratify that risk. nature.com/articles/s41591-0… (Figure 4, really). 2/
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We live twice as long on average as we did 100 years ago. For that, we mostly thank public health/clean water, antibiotics, and vaccines. 2/2
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Now, we have noticed that infectious can spread through shared respirations. WE HAVE NOTICED. We can systematically relate those issues to infection. And, in some cases, we have. 5/
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We don’t fully understand risk, yet, but we have noticed, and we will understand risk, shortly. Change is always hard, it is easy to trust in the processes with which we are familiar. That doesn’t mean they are always better. 6/6
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If the difference in progression is uniformly 27% less, it would be great. But extrapolating progression from people with MMSE 25-27. and hoping it applies when MMSE is 20, is quite a leap. 10/
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Still, based on the press release (caveat emptor), IT WORKS. And if it works, at a bare minimum, it will point the way for future monoclonal, and other, therapeutic attempts. It is PROGRESS! 11/11
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So I usually tell laypeople it is 4-5 years from diagnosis to needing nursing home care, because most people won't seek diagnosis until MMSE is 25 (actually many never seek it at all like my uncle-in-law). 7/
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Now, these "average" rates of progression are modified by Apoe4 status, sex, and inversely by age. Age is the strongest of those factors, older progresses slower. THESE ARE NOT ONE SIZE FITS ALL. Individuals are still, well individual and need not fit the trend. 8/
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