Philadelphia, PA
Joined February 2020
- Tweets209
- Following205
- Followers172
- Likes1.1K
Ruchi Patel retweeted
Ruella Lab is proud to announce that @MarcoRuella has won @BloodCancerUtd Greater Philadelphia Visionary of the Year!
Thanks to all supporters to our campaign, YOU made a HUGE contribution to fight cancer!
@PennMedicine
Ruchi Patel retweeted
Analysis of longitudinal blood samples shows that #CD19 #CARTs can be detected at least 10 years post-treatment in patients with #lymphoma, with deeper profiling from a single patient showing that these CARTs have a dominant double negative activated effector memory-like phenotype.
@MarcoRuella @ruellalab @pennmedicine @paruzzol
nature.com/articles/s41591-0…
Ruchi Patel retweeted
Honored to join the most recent cohort of Damon Runyon Fellows. I’m grateful to the Damon Runyon Cancer Research Foundation for supporting ambitious research projects and excited to join a community of inspiring young scientists.
secure-web.cisco.com/1EMvwW-…
Ruchi Patel retweeted
Excited to share that my second paper from graduate school is out now at Nature Genetics. We show that Enhancer-Promoter interactions can form de novo in the absence of loop extrusion.
nature.com/articles/s41588-0…
Ruchi Patel retweeted
Exciting news: EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models @Cancer_Cell @MarcoRuella @AlbertoCarturan @PuneethGuru_ @_ruchipatel @yunlin_zhang_ @guido_ghilardi and my stellar co-author Siena Nason
cell.com/cancer-cell/abstrac…
Ruchi Patel retweeted
Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.biorxiv.org/content/10.1101/…
Ruchi Patel retweeted
cell.com/molecular-cell/full…
Our paper is now online @MolecularCell. Architectural protein LDB1 drives enhancer connectivity independently of CTCF/cohesin!
Ruchi Patel retweeted
Wild experience to have seen our story shared at the #ASH24 Plenary in San Diego by my wonderful co-lead @Shan_Liu_ ! Looking forward to further proving that we can enhance cancer treatment by modulating readily-actionable patient lifestyle factors.
A simple dietary supplement may provide a new approach to boost #CART cell function – hear more in the #ASH24 Plenary Session today. @MarcoRuella @MaayanLevy_Lab @PuneethGuru_ spr.ly/6015QKswz
Ruchi Patel retweeted
Grateful to #ASH2024 for the chance to present our work on overcoming the absence of CD2:CD58 co-stimulation using an innovative PD1:iCD2 switch receptor. Thanks to my mentor @MarcoRuella and the @RuellaLab for their invaluable support. Excited to delve deeper into this approach!
Ruchi Patel retweeted
Learn more about the exciting advances in blood cancer and benign hematology research that Penn Medicine and @PennCancer experts will be presenting at the @ASH_hematology Annual Meeting this weekend. #ASH24 spr.ly/6015txypB
Ruchi Patel retweeted
#ASH24 Energy matters! Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate #CARTCell #TCell #tcellrx #immunotherapy @PennMedicine
ash.confex.com/ash/2024/webp…
Ruchi Patel retweeted
A simple dietary supplement may provide a new approach to boost #CART cell function – hear more in the #ASH24 Plenary Session today. @MarcoRuella @MaayanLevy_Lab @PuneethGuru_ spr.ly/6015QKswz
Looking forward to discussing our latest work on CD5 next week! Register here to join: workcast.com/register?cpak=2…
Ruchi Patel retweeted
Very excited to share this work that could not have been done without the help of @RaisBahrami and @arnabguonc ! Big thank you to The Oncologist for this opportunity!
High-sensitivity #ctDNA tests can be used to detect radiologically occult disease or minimal residual disease post-surgery & identify high-risk patients. This review summarizes current evidence, w/ focus on genitourinary tumors. @KartikPatel___
doi.org/10.1093/oncolo/oyae1…
Ruchi Patel retweeted
Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin!
biorxiv.org/content/10.1101/…
Ruchi Patel retweeted
The effectiveness of #CARTCellTherapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, according to research led by @PennCancer's Dr. @MarcoRuella. spr.ly/6012YGdWi
Ruchi Patel retweeted
In a study published in @SciImmunology, @PennMedicine researchers identify #CD5 as an immune checkpoint protein & potential target of future cancer therapies ft. @MarcoRuella (@PennCancer) tinyurl.com/4nzzy3bs
Ruchi Patel retweeted
A discovery from PICI Investigators @Penn has revealed that deleting the CD5 gene in CAR T cells significantly enhances their antitumor activity across multiple cancer types, opening new avenues for more potent and effective immunotherapies. science.org/doi/10.1126/scii… (5/5)
Ruchi Patel retweeted
Patel et al. used the CRISPR-Cas9 system to ablate expression of the TCR-associated T cell inhibitory receptor CD5 from CAR T cells of several specificities and TCR-redirected T cells. bit.ly/4cnT9J7 @_ruchipatel @MarcoRuella @PennMedicine
Looking forward to joining @pillar_vc Frequency Bio's Cohort 10 next week! Excited to learn more about the biotech startup community.
