When I was an intern in a hospital, I isolated E. Coli from a patient's urine. I became super suspicious. How did E. coli get to this man’s urethra? Until I heard from the nurses that there was something wrong with his anus. To cut this short he was a homosexual who gives and takes penis to the anus. Moral of this: you clearly don't want E. Coli where it shouldn't be. Urethra, kidney anywhere except the intestine.