The August issue is live nature.com/nbt/volumes/44/is… The cover shows an illustration of hemorrhagic stroke debris being cleared from the mouse brain by ultrasound. Azadian et al. develop a focused ultrasound protocol that clears pathogenic debris from the brain through the meningeal lymphatics in two mouse models of stroke go.nature.com/4nO5s71 rdcu.be/fzlEz

Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells nature.com/articles/s41587-0…

The July issue is live nature.com/nbt/volumes/44/is… On the cover, the microbiome is depicted as an interconnected network in which relationships among genes and proteins provide context for uncovering hidden biological functions. Zhang et al. introduce FUGAsseM, a method that uses microbial community data to infer the functions of previously uncharacterized gene products go.nature.com/435C4lp rdcu.be/ftNUV

The June issue is live nature.com/nbt/volumes/44/is… The cover shows an illustration of vascularized tumors on a chip. Liu et al. present a long‑term, perfused system for human solid tumors that supports CAR‑T delivery and real‑time analysis of tumor–CAR‑T dynamics, evaluation of engineering strategies, and identification of druggable targets go.nature.com/3Jc62gv rdcu.be/foISS

The May issue is live nature.com/nbt/volumes/44/is… On the cover, Zhang et al. describe an antibody-based therapy against drug-resistant S. aureus. The antibody conjugate selectively binds to the wall teichoic acid of the bacteria and enriches calcium on the cell envelope, induces bacterial death and boosts immunogenicity go.nature.com/3UaGItg

The March issue is live nature.com/nbt/volumes/44/is… On the cover, Chen et al. engineered TadA-derived mitochondrial DNA adenine base editors for efficient mtDNA A-to-G editing with expanded targeting scopes and minimal off-target effects. This robust editing approach led to the successful generation of mitochondrial disease models go.nature.com/3TaxaOg go.nature.com/4dHqZea

The February issue is live nature.com/nbt/volumes/44/is… On the cover, barcoding microbial ribosomal RNA creates a record of gene transfer events without requiring translation. Kalvapalle et al. designed catalytic RNAs to barcode host RNA upon gene transfer, allowing high-throughput sequencing to identify the community involved go.nature.com/440gL5E

The January issue is live nature.com/nbt/volumes/44/is… On the cover, Luebbert et al. present a method to detect viral sequences in bulk and single-cell transcriptomic data using conserved amino acid domains instead of annotated reference genomes go.nature.com/4lGrSY3

Balancing immunity with Tregs go.nature.com/4qNezXD

The December issue is live nature.com/nbt/volumes/43/is… The cover shows a representation of hybrid quantum computing for drug design. Ghazi Vakili et al. present a hybrid quantum–classical generative model to design molecules to inhibit KRAS activity. Two candidates are synthesized and further characterized go.nature.com/3EitbLm

Antibody-lectin chimeras for glyco-immune checkpoint blockade go.nature.com/4aRDpk8

2025: research in review go.nature.com/4oCK84L

The November issue is live nature.com/nbt/volumes/43/is… On the cover, lipid nanoparticles targeting the lung, designed using neural networks. A method developed by Witten et al. identified two structures that efficiently delivered mRNA to ferret lungs go.nature.com/4fbj0VU

Join us as we take a step back in time and celebrate all we have accomplished in immuno-oncology over the past 40 years! We will be remembering all our IO milestones as we lead up to our 40th Anniversary Annual Meeting! sitcancer.org/2025/home

A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors go.nature.com/3Jc62gv

The October issue is live nature.com/nbt/volumes/43/is… The cover shows perturbations that convert stem-like, atypical teratoid rhabdoid tumor (AT/RT) cells into a more differentiated, neuron-like state go.nature.com/4hXER5O

The September issue is live nature.com/nbt/volumes/43/is… On the cover, a system for high-precision mutation detection of mRNA in extracellular vesicles. Song et al. present SCOPE, a method that uses Cas13 to recognize and amplify target RNA for liquid biopsy applications go.nature.com/47Yw8Mf