@_RiniShah

Postdoc @ElphegeNoraLab at UCSF studying genome folding

 San Francisco, CA
Joined December 2019
  • Tweets50
  • Following451
  • Followers157
🧵How does the genome find its place in the 3D space of the nucleus after fertilization? Out now @CellCellPress: cell.com/cell/fulltext/S0092… 👇 A thread 👇

The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic...

In vivo screening in mouse embryos provides insights into the functional interplay between chromatin and the nuclear envelope in the establishment of lamina-associated domains, the earliest feature...

cell.com
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CTCF stall DNA 🧬 loop ➰ extrusion by cohesin - but exactly how it pulls this off is a 'mechanistic mystery' (to cite @Anders_S_Hansen , Nucleus, 2020). We just preprinted 📜 a new study @biorxivpreprint that provides some answers to this enigma: tinyurl.com/3r2a4ux2
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Rini Shah retweeted
Schuh Lab@SchuhLab23 Dec 2024
Why are some chromosomes like #21 in Down syndrome more error-prone in mammalian eggs? 🤔 Our new study in @NatureComms reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9) nature.com/articles/s41467-0…
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Schuh Lab@SchuhLab21 Oct 2024
Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)
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Schuh Lab@SchuhLab16 Oct 2024
Each month an #egg is ovulated from the #ovary, starting the journey of reproduction. But how does ovulation occur?🥚 Our latest work in @NatureCellBio led by @LastChrisThomas and @Tabea_Marx, describes the control of #ovulation using live imaging. bit.ly/3Ya8dEL (1/7)
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Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion biorxiv.org/content/10.1101/…

Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy

In mammalian interphase cells, genomes are folded by cohesin loop extrusion limited by directional CTCF barriers. This interplay leads to the enrichment of cohesin at barriers, isolation between...

biorxiv.org
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First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.1101/… (1)

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...

biorxiv.org
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Beyond thrilled to present our first (!) work @TheCrick! A tour de force by @tobyandrews et al combining imaging, solid morphometrics, theory, perturbations to show how a developing heart grows and scales up its morphological complexity to keep beating... biorxiv.org/content/10.1101/…
Toby Andrews@tobyandrews25 Jul 2024
Pumped to share our latest and first (!) work from @_Priya_R lab @TheCrick! Using the powers of #zebrafish, we uncover how multiscale mechanochemical coupling drives morphological and functional maturation of the developing heart 🫀 Stay tuned for the🧵 biorxiv.org/content/10.1101/…

Multiscale mechanics drive functional maturation of the vertebrate heart

How simple tissue primordia sculpt complex functional organs, robustly and reproducibly, remains elusive. As the zebrafish embryo grows into a larva, to improve its heart function, the embryonic...

biorxiv.org
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(1/16) Check out our @SimonMJGaudin paper tiny.cc/icuazz from the Canzio lab out in @ScienceMagazine today on how tuning local cohesin trajectories enables differential readout of the clustered Protocadherin (Pcdh) locus across different types of neurons.
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'The Mechanics of building functional organs - our take on this fundamental problem. We discuss general design rules building complex 3D geometries, advocate for a holistic understanding of morphogenesis by embracing the complexity of embryonic development.cshperspectives.cshlp.org/co…
Toby Andrews@tobyandrews18 Jun 2024
How do embryos build organs with the right shape, size and function to keep our bodies ticking?🫀🫁👀 @_Priya_R and I give our take here, in a rollercoaster ride from local cell behaviors to organ-scale physiology and back cshperspectives.cshlp.org/co…
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📢'The World Is Your Oyster' is for those who are born in global north countries--don't experience visa bureaucracy & emotional burden that non-white global south scholars do. Citizenship is a privilege that we need to recognize in the academe. 1/n nature.com/articles/d41586-0…
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Elated indeed to see our work getting featured on the @GenesDev cover! Want to acknowledge all the sci-art exposure in @METorresPadilla lab and in our @ChromDesign PhD network! Special mention to @carla_molins and @francesc_ribot for always motivating and inspiring!!
Genes & Development@GenesDev16 Nov 2023
NEW ISSUE ALERT!! Check out the new Research Papers and Outlook online now at Genes & Development. Click on the link for more: ➡️genesdev.cshlp.org/content/c…
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It took Sergey Ulyanov and I a while to shape fountains, a novel type of chromatin architecture. Here is our story of pioneering factors binding (@onichtchouk) and the loop extrusion (@leonidmirny) working together. (can you tell that I’ve been into fishkeeping since I was six?)
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Our work describing Chromatin Expansion Microscopy is now out in @ScienceMagazine science.org/doi/10.1126/scie… Check out how we were able to visualize transcription, chromatin, and TFs with molecular resolution in developing zebrafish embryos to understand gene regulation!

Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin

In vivo imaging with chromatin expansion microscopy reveals principles of pioneer factor–controlled transcription in zebrafish embryos.

science.org
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(1/11) Check out our paper tinyurl.com/25wvf2v2 now out in @ScienceMagazine on the role of cohesin-mediated loop extrusion in clustered Protocadherin expression and how that influences neural wiring patterns.
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Today's news about transit funding is a step closer to avoiding the fiscal cliff. There is still work to do and more to learn about what this means for Bay Area transit agencies, but we are moving in the right direction.
Senator Scott Wiener@Scott_Wiener12 Jun 2023
BIG TRANSIT FUNDING UPDATE Last night, the Senate & Assembly released our budget, including most of the agreement on transit. We vote on Thursday. The agreement is a strong step to address the transit operations fiscal cliff. More work remains, but this is good progress.🧵⬇️
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Super excited to introduce seminar series along with @DeepaSubramany4 and with immense support from @IndiaBioscience. This series will be conceptually different as speakers will not only discuss exciting science but more importantly unheard stories behind these discoveries!!
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Opportunity to apply for a PhD fellowship to study gene dosage regulation on the X chromosome @CbiToulouse with @rafaelgalupa. Deadline: 8th June. More information here: jobrxiv.org/job/cnrs-centre-…

Science Jobs - Find science and research jobs - 3,327 jobs

The international job board for scientists, by scientists. Find science jobs in academia or industry: MSc, PhD, Postdoc, Scientist, Faculty and more!

jobrxiv.org
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Ever wondered how transient transcription factor DNA binding can robustly activate transcription? In this new preprint, we find support for one of the possible mechanisms: transcription factors exchange. A 🧵 1/9. biorxiv.org/content/10.1101/…

Transcription factor exchange enables prolonged transcriptional bursts

Single-molecule imaging inside living cells has revealed that transcription factors (TFs) bind to DNA transiently, but a long-standing question is how this transient binding is related to transcrip...

biorxiv.org
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Stressed plants emit airborne sounds that can be detected from over a meter away. Lilach Hadany @YovelBatLab @TelAvivUni Learn more in @CellCellPress: cell.com/cell/fulltext/S0092…
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