I read a lot of PubMed. Looking for overlaps in transition metal homeostasis, histamine intolerance, microbiome disruption (bacterial and/or fungal) and IBD.
Dallas, Texas
Joined May 2010
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Back on my soapbox for a minute. Really wanting to see IBD research looking at chronic ingestion if Type IV hypersensitivity foods, like high nickel or high cobalt, zinc/calcium transport, and how that affects pathogenic bacteria like AIEC. #crohns #ibd #microbiome
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Katie Smith retweeted
Until now, the gut microbiome hasn't been used to make clinical diagnoses. That may change. A new report on its utility for non-invasively diagnosing inflammatory bowel disease.
nature.com/articles/s41591-0…
@NatureMedicine @Siew_C_Ng
#Nickel levels have not previously been evaluated in #IBD, but several studies refer to the disrupting role of nickel in gut microbiota eubiosis (37). Our results agree in part with these as nickel levels were higher in active CD compared to inactive UC… frontiersin.org/articles/10.…
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I’ve been asking about this for 5 years…
#Nickel particles are present in #Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice - PubMed pubmed.ncbi.nlm.nih.gov/3503…
Hystometric evaluation of nickel chronic exposure effects on large instestine of adult Wistar male rats | Revista de Ciencias Agrícolas revistas.udenar.edu.co/index…
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A Compound That Reverses Gut Inflammation Developed - Neuroscience News neurosciencenews.com/fexd-gu…
Prometheus Biosciences Announces Positive Results for PRA023 in Both ARTEMIS-UC Phase 2 and APOLLO-CD Phase 2a Studies Enabling Pathway to Both First-in-Class and Best-in-Class Anti-TL1A mAb | Prometheus Biosciences ir.prometheusbiosciences.com…
Nanoparticle Probiotic “Backpacks” Show Promise for Treating Inflammatory Bowel Diseases Like Crohn’s and Ulcerative Colitis scitechdaily.com/nanoparticl…
Study points to potential new treatment for inflammatory bowel diseases medicalxpress.com/news/2022-…
What’s metal got to do with it? Transition metals in Clostridioides difficile infection - ScienceDirect sciencedirect.com/science/ar…
Let’s start looking at metal homeostasis or metal manipulation and #IBD. #calprotectin
Nickel chelation therapy as an approach to combat multi-drug resistant enteric pathogens ncbi.nlm.nih.gov/pmc/article…
Crohn's disease: Common infection may be suspected trigger medicalnewstoday.com/article…
So excited for our son to be home for a long weekend after his 1st 2 months of college! #baylorbear 💚💛💚
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Frontiers | Increased Zinc Availability Enhances Initial Aggregation and Biofilm Formation of Streptococcus pneumoniae frontiersin.org/articles/10.…
Excess #Nickel->e coli biofilm; excess #cobalt-> staph #biofilm
Need transition metal homeostasis to maintain gut health; iron, calcium, nickel, cobalt, zinc
#Calprotectin -> natural defense against bacterial imbalance
Fix with #probiotics, diet, and increase in #butyrate?
Nickel Promotes Biofilm Formation by Escherichia coli K-12 Strains That Produce Curli | Applied and Environmental Microbiology journals.asm.org/doi/10.1128…
Contact Dermatitis Due to Nickel Allergy in Patients Suffering from Non-Celiac Wheat Sensitivity ncbi.nlm.nih.gov/pmc/article…
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#Butyrate !! #IBD Food allergies can be reversed in mice by targeting the microbiome - American Chemical Society acs.org/content/acs/en/press…
Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice - ScienceDirect sciencedirect.com/science/ar…