For microbiome, we enable methylation binning using @nanopore seq + plasmid mapping + misassemblies detection. We found abundant 5mC motifs, suggesting previous underestimation and many new research opportunities. BTW. We're hiring, join us?! Full Ad: bit.ly/3mmskME 3/3

Bacterial 6mA & 4mC studies in the past 10 yrs mainly powered by @PacBio seq. NanoDisco now enables the use of @nanopore seq for de novo 6mA, 4mC & 5mC motif discovery (Software bit.ly/3mkoS5g). The two platforms are still complementary as discussed in our new paper. 2/3

Our NanoDisco paper online @naturemethods go.nature.com/3sRKFUh  (Congrats @AlanTourancheau!! FANTASTIC work!): #methylation discovery (6mA, 4mC, 5mC; de novo, diverse motifs, specific type, exact base) from #bacteria & #microbiome + methylation binning using @nanopore seq. 1/3