Computational Molecular Biology @Technion @biologytechnion
Joined March 2019
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Mandel-Gutfreund Lab retweeted
๐ Viruses vs. Human Cells: The Evolutionary Arms Race๐งฌ
Technion researchers uncover a unique mechanism in human cells that rapidly activates the immune system against viruses. A breakthrough in fighting infections and understanding evolution! ๐ฌ๐งฌ Study in @NatureComms led by Prof. Yael Mandel-Gutfreund & @AArgoetti of @BiologyTechnion
#Biology #Immunology #TechForHealth
technion.ac.il/en/blog/articโฆ
Weโre thrilled to share our new paper! ๐
This study reveals how the lncRNA NORAD interacts with STAT3 to regulate the antiviral response.
Congratulations to Amir and the entire team for their incredible work!
@BiologyTechnion @TechnionLive
nature.com/articles/s41467-0โฆ
1/7 Iโm excited to share our paper, describing the majority of my PhD, now published in @NatureComms!
We present how the lncRNA NORAD interacts with STAT3 to regulate the antiviral response in human cells. A ๐งต
Mandel-Gutfreund Lab retweeted
Does anyone know of a gorilla cell line?
And if so, does anyone in Israel have one and is willing to give us a vial?
Mandel-Gutfreund Lab retweeted
ืื ื ืืืืข, ืคื ืื ืื ืืื ืกืืืฉ, ืืื ืืคืืชื ืืืืื ืืืืื ืืืืจื ืืฆืจืคืชืื ืฉืื @GaliaPolyak ืฉืืฆืืื ืืขืื ืืื ืฉืขืืช ืืช ืืืืกืืจ ืืกืืคืจ ืืืฆืื ืฉืื ืืื ื ืืื ืืื ืื!
ืืื ืืชื ืืืงืจื ืืืื ืืื ืืืื ื12:30, ืืืืื ืืชืื ืืฉืืืข ืขื RNA ืจืืืืืืจื ืืืชืคืชืืืช ืขืืืจืืช (ืืืืขืื ืืืืืืื ๐)
Mandel-Gutfreund Lab retweeted
Hi RNA feed!
Does anyone here know of a small-molecule or non-protein RNAse inhibitor?
All the RNase inhibitors I found are large proteins that can disrupt my assay
Mandel-Gutfreund Lab retweeted
๐ฐThe Unexpected Match: STAT3-NORAD Interaction, a Novel Link in Antiviral Defense biorxiv.org/content/10.1101/โฆ
Mandel-Gutfreund Lab retweeted
In summary, a surprise twist in evolution unlocked NORAD's new feature!
It can now mediate the nuclear entry of STAT3, thereby inhibiting the interferon response in primates.
Upon viral infection, NORAD is cleaved, prompting STAT3's exit and activating the antiviral response.
Mandel-Gutfreund Lab retweeted
Unfulfilled with its conserved partnership, NORAD found a new match...
Please welcome our preprint on how an ALU element equipped NORAD in the arms race against viruses!๐งต
The Unexpected Match: STAT3-NORAD Interaction, a Novel Link in Antiviral Defense
biorxiv.org/content/10.1101/โฆ
Mandel-Gutfreund Lab retweeted
cool!
should be useful
RBPmap is back!
If you need an accurate prediction of RBP binding sites, look no further >>
rbpmap.technion.ac.il
@BiologyTechnion
@TechnionLive
Mandel-Gutfreund Lab retweeted
RBPmap is back!
If you need an accurate prediction of RBP binding sites, look no further >>
rbpmap.technion.ac.il
@BiologyTechnion
@TechnionLive
We're back online!
xitter.cf/YaelmgLAB/status/16562โฆ
RBPmap is back!
If you need an accurate prediction of RBP binding sites, look no further >>
rbpmap.technion.ac.il
@BiologyTechnion
@TechnionLive
RBPmap is back!
If you need an accurate prediction of RBP binding sites, look no further >>
rbpmap.technion.ac.il
@BiologyTechnion
@TechnionLive
Amir Argoetti @AArgoetti gave a seminar on his PhD project.
Amir is the first fully-experimental doctorate student graduating from the Mandel-Gutfreund lab, so this was an emotional day.
Incredibly proud of you! We expect great things from you
Mandel-Gutfreund Lab retweeted
#lncRNAfeed
Does anyone know how many base pairs around the sgRNA are closed by CRISPRi?
We are debating knockdown approaches of a nuclear lncRNA that is back to back to a protein-coding gene
@YaelmgLAB
Mandel-Gutfreund Lab retweeted
Iโm honored and flattered to receive The Prof. David and Harriet Gershon Excellence Fellowship.
I would like to thank the Gershon family and committee for choosing me and for appreciating my science and my social activities
Recipient of the Gershon award @AArgoetti gave a short presentation of his project at the Biology Faculty Retreat. Congratulations! We expect great things from you!
@BiologyTechnion
@TechnionLive
Recipient of the Gershon award @AArgoetti gave a short presentation of his project at the Biology Faculty Retreat. Congratulations! We expect great things from you!
@BiologyTechnion
@TechnionLive
Great talk Galia!
We are very proud of you
The very talented @GaliaPolyak represents @YaelmgLAB at the faculty retreat, talking about lncRNAs-mediated regulation of human embryonic development
Great talk Galia! ๐คฉ
@BiologyTechnion
@TechnionLive
Celebrating the beginning of a new semester and welcoming @HibaHassanain and Yuval to the YMG lab with a PASTA night!
Thankfully, Tamar is a pasta master ๐๐ฎ๐น
