Currently Postdoc @Hsu_Lab_UVA; Postdoc @CUHKMedicine; PhD at SYSU. Chemical proteomics & Drug discovery.
Austin, TX
Joined November 2019
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Xiaoding Jiang retweeted
A covalent PFKL activator suppresses tumor growth
nature.com/articles/s41589-0…
Xiaoding Jiang retweeted
Thanks @UTAustin, @TexasScience & @UTChemistry for the highlight!
cns.utexas.edu/news/research…
The UT CNS feature describes the study as a UT Austin-led effort and highlights Xiaoding Jiang’s role in designing the molecule.
Xiaoding Jiang retweeted
Thrilled to share our new paper in Nature Chemical Biology led by Xiaoding Jiang. We developed XJ-4-85, a covalent PFKL activator that delivers a CPT2-targeting payload and suppresses tumor growth in vivo. Thanks to the Cambronne, Webb, and Kollman labs!
doi.org/10.1038/s41589-026-0…
Xiaoding Jiang retweeted
Excited to share new findings led by postdoctoral fellow Xiaoding Jiang. We developed an electrophile-drug conjugate (EDC) that site-specifically and proteome-wide selectively activates PFKL coupled to delivery of a cytotoxic payload in vivo biorxiv.org/content/10.1101/…
Xiaoding Jiang retweeted
[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/full/10.102…
Xiaoding Jiang retweeted
Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the toolbox for ligand discovery and chemical biology. Congrats to Gibae Kim from my group!
pubs.acs.org/doi/10.1021/acs…
@CovalentMod @UTChemistry @UTAustin
Xiaoding Jiang retweeted
Innate immune memory after brain injury drives inflammatory cardiac dysfunction: Cell 🧐cell.com/cell/fulltext/S0092…
Xiaoding Jiang retweeted
The value of ‘wasting time’ on deep thinking is often overlooked in a scientific ecosystem increasingly tainted by Wall Street’s productivity mindset.
nature.com/articles/d41586-0…
Xiaoding Jiang retweeted
Excited to share our latest @JACS_Au paper on the late-stage editing of the Ginkgo biloba natural product!🍀 Huge thanks to our talented postdocs @XiaodingJ & Jon Wong, and PhD student Xu He for their incredible efforts! 👩🔬👨🔬Link: pubs.acs.org/doi/epdf/10.102…
Xiaoding Jiang retweeted
How to Write Clearly
#PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science #job #Postdoc
Xiaoding Jiang retweeted
.@cuhkpharmacy has designed a novel class of small molecules named O-GlcNAcylation Targeting Chimeras (OGTACs), offering a pioneering method for precisely manipulating #protein function in living #cells, with the potential to revolutionise the #treatment of a range of #diseases. bit.ly/3KlDG0j
📖@J_A_C_S: bit.ly/3yNEHM2
ALT .@cuhkpharmacy has designed a novel class of small molecules named O-GlcNAcylation Targeting Chimeras (OGTACs), offering a pioneering method for precisely manipulating #protein function in living #cells, with the potential to revolutionise the #treatment of a range of #diseases. https://bit.ly/3KlDG0j 📖@J_A_C_S: https://bit.ly/3yNEHM2
Xiaoding Jiang retweeted
Online now! Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation dlvr.it/T7BmG8
Xiaoding Jiang retweeted
“Science is like art, it is creative. We are not creative if you are only talking to some people. We need to talk to everybody.”
Watch Nobel Prize laureate @MayBrittMoser discuss how diversity impacts creativity at our #NobelPrizeDialogue: youtube.com/live/99VjiKDv-VA…
ALT May-Britt Moser on stage in a light blue suit.
ALT May-Britt Moser on stage in a light blue suit. Next to her are panellists Jaqueline Goes and Vinícius Soares. They are sitting in chairs next to each other and in front of them are tables with the Nobel Prize logo.
Xiaoding Jiang retweeted
USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Xiaoding Jiang retweeted
The anticancer efficacy of CAR T cells is enhanced by overexpression of FOXO1. nature.com/articles/s41586-0… nature.com/articles/s41586-0… #NBThighlight
Xiaoding Jiang retweeted
Delighted to share our "OGTAC" story as an open-access article on @J_A_C_S !😉 #glycotime
Link: pubs.acs.org/doi/10.1021/jac…
Xiaoding Jiang retweeted
Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules | Journal of the American Chemical Society @Billy_WL_NG @CUHKMedicine #Protein #GlcNAcylation #Bifunctional #SmallMolecules pubs.acs.org/doi/10.1021/jac…
Xiaoding Jiang retweeted
Phenomenal new reactions, new oxaziridine reagents, and their application in the discovery of functional tryptophan interactions. 👍👍👏👏
@christhechang @Toste_Group
nature.com/articles/s41586-0…
Xiaoding Jiang retweeted
What is a scientific paper?
Why do we write it?
How?
This 3-page handout, created by George Whitesides on 4 October 1989, offers practical answers.
Strongly recommended for researchers of all ages.
Whitesides' Group: Writing a Paper
intra.ece.ucr.edu/~rlake/Whi…
Xiaoding Jiang retweeted
nature.com/articles/s41589-0… Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determine PAL probe interaction sites in cells, enabling ID of diverse binding pockets, providing evidence of their chemical tractability & more w/@ForliLab & @bmsnews