New preprint from our team @chiluncellbio : OPA1 doesn’t just regulate mitochondrial fusion — a subpopulation localizes to lipid droplets and actively controls fatty acid release.
biorxiv.org/content/10.64898….
We show:
1) Exon 4 encodes an amphipathic helix that targets OPA1 to LDs
2) LD-localized OPA1 recruits lipases and promotes FA release
3) LD targeting competes with mitochondrial localization and alters mitochondrial connectivity
Xiao Li retweeted
.@XiaoLinichd, Gamuyao, @chiluncellbio et al. @stjuderesearch engineer a #LipidDroplet (LD)-targeting motif and develop a tool kit that can track contact sites between LDs and other organelles in living cells. hubs.la/Q02F1yfK0
@Daniel_Stabley @alexcarisey @agtebo
Xiao Li retweeted
We are thrilled to introduce FABCON, a “Fluorogen-Activated Bimolecular complementation at CONtact sites” tool kit for interrogating lipid droplet-organelle interaction and beyond in living cells.
biorxiv.org/content/10.1101/…
Xiao Li retweeted
A postdoctoral position in microbial pathogenesis is available in the Machner Lab at NIH.
Help us determine how Legionella pneumophila modulates host cells during infection.
For more details go to
nichd.nih.gov/research/atNIC…
Interested in how a Legionella phospholipase effector and phospholipids regulate pathogen-containing-vacuole expansion within host cells? Check out our @MatthiasMachner paper! Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pnas.22…
Xiao Li retweeted
Job Alert!
We are hiring postdocs & scientists to interrogate the subcellular spatial organization of metabolism! These positions are supported by DP2 award @NIH_CommonFund and @StJudeResearch offering amazing training opportunities, generous salary/benefits, and GREAT science!
Xiao Li retweeted
The Chang lab @stjuderesearch is looking for highly motivated postdocs and scientists to join us!
We apply innovative tools and approaches to interrogate the dynamic spatial organization of inter-organelle logistics. Details here, stjude.org/research/labs/cha…
