Xiaojun Ren Group at UNC Charlotte retweeted
Transcription factor specificity isn’t encoded by DNA motifs alone. Live-cell single-molecule imaging shows that unstructured transcription factor interactions enable emergent specificity.
science.org/doi/10.1126/scie…
Xiaojun Ren Group at UNC Charlotte retweeted
Academia cannot be reformed until the PhD has standards again.
The degree should be reserved for the relatively few candidates whose dissertations create important new knowledge - not awarded as a certificate of persistence to nearly everyone who remains in a program long enough.
A system with meaningful standards must permit meaningful failure. Candidates who are unlikely to make a substantial original contribution should be identified early, given a respectable off-ramp, and allowed to enter the job market years sooner.
This would reduce the oversupply of PhDs competing for a tiny number of academic positions and grants. With fewer people trapped in that cutthroat competition, academia would reward fewer of the behaviors produced by desperation and scarcity.
Companies accustomed to an abundant supply of PhD applicants would also have to recruit from the larger pool of capable people who left doctoral programs without the degree. The skills would remain valuable; only the credential would become scarce.
If the PhD once again signified exceptional scholarly, it would resolve many of academia’s current pathologies.
Xiaojun Ren Group at UNC Charlotte retweeted
“Spatial Organization of Epigenetic Information by Phase Separation” presented by Xiaojun (XJ) Ren, Ph.D. on Tuesday, April 21, 2026 – 11:00 am – 12:00 pm
1131 Bioinformatics Host: Jill Dowen
Join us for our last seminar of the Spring semester.
Xiaojun Ren Group at UNC Charlotte retweeted
New article about our research: science.charlotte.edu/2026/0…
Xiaojun Ren Group at UNC Charlotte retweeted
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs dlvr.it/TPffCB
Xiaojun Ren Group at UNC Charlotte retweeted
Happy to see this coming out at JCB!
Rongwei Zhao et al. @lab_zhang @CarnegieMellon show that, in #cancer cells using the alternative lengthening of telomeres (ALT) pathway, #SUMO levels at #telomeres influence the formation of ALT-associated PML bodies. hubs.la/Q03GK3qh0
Xiaojun Ren Group at UNC Charlotte retweeted
Imaging single endogenous RNA in live cells comes true!
Single-molecule live-cell RNA imaging with CRISPR–Csm go.nature.com/3EJPKsM
Xiaojun Ren Group at UNC Charlotte retweeted
Really excited to unveil sandbox.bio, an interactive playground for learning bioinformatics command-line tools like bedtools, bowtie2, and samtools (and more to come!) 🧑💻 🧬
Thanks to @aaronquinlan, @BenLangmead, and @mike_schatz for feedback and tutorial ideas.
Xiaojun Ren Group at UNC Charlotte retweeted
Threonine-rich carboxyl-terminal extension drives aggregation of stalled polypeptides: Molecular Cell cell.com/molecular-cell/full…
Xiaojun Ren Group at UNC Charlotte retweeted
Excited to share that our paper cell.com/molecular-cell/full… got the cover of the new issue of @MolecularCell. Extra cool that this is a photograph taken by the first author @Nancybrillet, a super-star research assistant and post-bacc who just started grad school @UTSWGradSchool
Xiaojun Ren Group at UNC Charlotte retweeted
So cool to see @tgwgraham’s work featured in the @Nature Briefing today! Read more about our developments to detect single molecule protein-protein interactions in live cells here : nature.com/articles/d41586-0…
Xiaojun Ren Group at UNC Charlotte retweeted
Registration for the 5th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer is NOW OPEN! Get ready to hear from an all-star lineup of speakers – you won't want to miss this. Register for free: bit.ly/chromatin-2024 #chromatin2024
Xiaojun Ren Group at UNC Charlotte retweeted
Proud of grad student @megan_mitchem on her winning image "Guardian of the Cell" in the @ASBMB Molecular Motifs bioart competition! 🔥🔥🔥asbmb.org/asbmb-today/people… #hsp70 #chaperone @unccharlotte @UNCCBiology
Xiaojun Ren Group at UNC Charlotte retweeted
Please RT: We have Senior Scientist, Postdoctoral Researcher and PhD student positions available in our lab focusing on the role of Hsp70 PTMs in a variety of processes including cancer, aging and host-pathogen interactions. Please see: trumanlab.org/contact #hsp70 #chaperones
Xiaojun Ren Group at UNC Charlotte retweeted
Demixing is a default process for biological condensates formed via phase separation: science.org/doi/10.1126/scie…
Xiaojun Ren Group at UNC Charlotte retweeted
Congratulations Shankar Balasubramanian of @Cambridge_Uni, newly inducted NAS international member! #NAS161 #NASmember #chemistry #biochemistry
Xiaojun Ren Group at UNC Charlotte retweeted
Happy to share that our work on how small set of motifs and rules explain most human promoters is published in @ScienceMagazine I am very grateful for the chance to be part of a team of amazing scientists: Donghong Cai, Chenlai Shi,@JianXuLab,@zhou_jian science.org/doi/10.1126/scie…
Xiaojun Ren Group at UNC Charlotte retweeted
Online Now: A validation strategy to assess the role of phase separation as a determinant of macromolecular localization dlvr.it/T5QQqF
Xiaojun Ren Group at UNC Charlotte retweeted
Happy to see this monumental effort by @gi_veronezi published! cell.com/cell-reports/fullte…
Xiaojun Ren Group at UNC Charlotte retweeted
Excited to share a new collaborative paper from my lab and the @transactivators lab where we find that condensate formation of the cell type specific coactivator Myocardin drives gene activation during cardiovascular differentiation.
science.org/doi/10.1126/scia…





























