
ALT Four panels show the changes from baseline to week 80 in the apnea–hypopnea index (AHI, the number of apneas and hypopneas per hour of sleep) in TRIUMPH-1-OSA (Panel A) and TRIUMPH-2-OSA (Panel C) and the percent changes in body weight from baseline to week 80 in TRIUMPH-1-OSA (Panel B) and TRIUMPH-2-OSA (Panel D).

ALT Four panels show percent changes in other OSA measures (hybrid-treatment estimand). Panels A and B show percent changes at week 80 in the AHI and the sleep apnea–specific hypoxic burden (SASHB, a measure calculated from a polysomnogram that encapsulates the frequency, duration, and depth of respiratory event–related oxygen desaturation) in TRIUMPH-1-OSA (Panel A) and TRIUMPH-2-OSA (Panel B). Panels C and D show the percentage of participants at week 80 with a 50% or greater decrease in AHI or an AHI of less than 5 or 5 to 14 events per hour with a score of 10 or lower on the Epworth Sleepiness Scale (ESS) in TRIUMPH-1-OSA (Panel C) and TRIUMPH-2-OSA (Panel D).




























