AI Engineering @bmsnews, previous management consultant and systems biologist - lover of digital biomedical research, views always my own

Philadelphia, PA
Joined May 2012
my computer sciences career arc has really come full circle - taught myself html 28 years ago and here am I now generating all reports and presentations in this format #AI
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Haven’t touched anything @meta related in probably ten years but exploring this new muse agent…
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model context protocols came up in >80% of my meetings this week - they arent coming, they are already here #MCP #AI
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This is the way
This is literally how developers use AI now: battle of the models.
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has @Google @GoogleAI every disclosed architectural and file processing details for #NotebookLM ?
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All I want from #AI is copy paste to always match style and formatting
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Definitely the most scientifically aware out of the box foundational model I've tested with translational medicine based questions #LLMs #AI
Anthropic is so back. Two things I like the most about Claude-3's release: 1. Domain expert benchmarks. I'm much less interested in the saturated MMLU & HumanEval. Claude specifically picks Finance, Medicine, and Philosophy as expert domains and report performance. I recommend all LLM model cards to follow this, so that the different downstream applications know what to expect. 2. Refusal rate analysis. LLMs' overly cautious answers to innocent questions are becoming a pandemic. Anthropic is typically on the ultra safe end of the spectrum, but they recognize the problem and highlight their efforts on it. Bravo! I love that Claude dials up heat in the arena that GPT and Gemini dominate. Though keep in mind that GPT-4V, the high water mark that everyone desperately tries to beat, finished training in 2022. It's the calm before the storm.
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Artificial intelligence (#AI) and machine learning (ML) continue to push the boundaries of what is possible in marketing and sales. Now, generative AI promises to disrupt the way B2B and B2C players think about customer experience, and growth. Learn more: mck.co/45Jwcwu
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The OG human gain/loss of function mutation #genetics
20y ago Discovery of PCSK9 genetics by Abifadel, Seidah, and Boileau Mutations cause genetic high LDL cholesterol (familial hypercholesterolemia), subsequently established to be gain-of-function *2y later, loss-of-function mutations = low LDL-C & resistance to heart attack
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🚨 myostatin inhibition 🚨
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Huge, if reproducible #molecularbiology101
😲 Time to revise textbooks 🤔 Title: "Transcription factors interact with RNA to regulate genes" "at least half of TFs also bind RNA, doing so through a previously unrecognized domain" cell.com/molecular-cell/pdf/…
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The first person I ever hired I met on @Twitter (hi @DanRyder3) - can my network help me again for this new open role? careers.bms.com/jobs/R157028… #biopharma #data #digital
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We like the frameworks #deeplearning
Applications of Transformers New survey paper highlighting major applications of Transformers for deep learning tasks. Includes a comprehensive list of Transformer models. arxiv.org/abs/2306.07303
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Great listen, lots of #AI #ML use cases from across the biopharma pipeline discussed (personal favorite liver fat prediction via @uk_biobank data🤖)
On today's Cross Validated podcast, we have Kim Branson, Senior Vice President and Global Head of AI and ML at GSK. GSK is one of the 10 largest pharmaceutical companies globally. @altcap In this episode, we discuss: - Applying ML to genetic data, clinical trials and more + gen AI to processes - Building on open source technologies and reusable components in models - Data and data generation as a critical asset - Regulatory framework on AI Subscribe for the next episode: t.ly/6imFA
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Don't come across this gene every day, here is an informative 2013 paper including Figure 1 with a visualization of the USP1 complex as a regulator of some cellular processes ncbi.nlm.nih.gov/pmc/article…
ISM3091, Insilico's novel synthetic lethality inhibitor targeting USP1, receives FDA IND approval. Designed by AI, it has shown +results in preclinical trials across multiple tumor cell lines and in vivo models & could tackle resistance to PARP inhibitors. lnkd.in/gBZzgP3t
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Looking forward to presenting on #FAIR #research #data at #BioIT23 today, hopefully see you at 3:10
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