@WilliamsLabUCL

Haematopoiesis and Leukaemia Group that aims to understand and target pathways using novel therapeutic approaches @UCL @DBC_ICH

Joined September 2020
  • Tweets102
  • Following187
  • Followers215
27Media
Pleased to share our latest publication in Cell Death & Disease, showing that MYB inhibition enhances sensitivity to MCL1-targeted therapy in pediatric AML. Congratulations to the entire team on this collaborative effort. nature.com/articles/s41419-0…
1
4
571
Massive thanks to my team, collaborators and funders! @WilliamsLabUCL @BelaPatel_lab @Yolandacalle @menz_mas @lucacozzuto @LeukUK
1
99
What is the clinical significance? #PP2A re-activation già forskolin Is a therapeutic strategy for KMT2A- rearranged #leukemia. Forskolin could be employed to improve the therapeutic index and tolerability of standard #chemotherapy daunorubicin
1
1
93
What does this study add? A comprehensive characterisation of #PP2A in over 300 AML #leukemia samples, a toxic effect of forskolin in leukemic cells with a repressive effect on C-MYC, HOXA9 and HOXA10 and unanticipated PP2A- independent sensitising activity to #chemotherapy
1
1
66
What is already known? Previous research identified #PP2A as a therapeutic target for acute myeloid #leukaemia and forskolin as a natural compound with anti-#Cancer effects
1
1
65
Very proud to share the recent results of our @LeukUK funded research Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia share.google/1tPM3CFPvmvkBtt… @UniOfSurrey @BrJPharmacol

BPS Publications

Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target...

bpspubs.onlinelibrary.wiley.com
2
3
2
5
471
Great opportunity to understand more on how to use oganoids to study diseases @GerliLab the-scientist.com/studying-o…

Studying Organ Development and Disease Using Organoids | The Scientist

In this symposium, an expert panel will discuss how cutting-edge organoid research lends insights into normal development and shows what happens when processes go awry.

the-scientist.com
6
16
915
Williams Lab retweeted
nature
@Nature19 May 2024
A model of a membrane called the blood–brain barrier could transform how scientists study drug delivery to the brain, as well as diseases of the brain’s vascular network go.nature.com/3ULhSjx
3
70
4
274
50,811
🚨🚨🚨🚨 Our new preprint is out! “Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations” 🩸🧫🧪🧬 biorxiv.org/content/10.1101/… The superteam of @cancer_curious and Dani Fernandez tackled a major unanswered question in HSC bio. 1/

Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver...

Cancer cells display wide phenotypic variation even across patients with the same mutations. Differences in the cell of origin provide a potential explanation, but these assays have traditionally...

biorxiv.org
23
96
6
393
72,322
This week selection of papers in myeloid leukemia biology and therapy is out. Enjoy the vast read and thanks as always @Bims_BiomedNews Here is the link biomed.news/bims-tremyl/2024…
7
9
2,010
Williams Lab retweeted
andi roy@andiroy19 May 2024
U.K. childhood leukaemia researchers- please join us on 19th Sep for the annual meeting- hosted by @Richardson_S_E in Cambridge. Keynote talk by Prof Brian Huntly. Register now!
CLR-UK Network@CLRUKnetwork19 May 2024
The annual meeting is on 19th Sep 2024 in Cambridge. Expression of interest to present your work or chair a session welcome (especially from students and ECRs!). Please register using form below 👇. forms.office.com/pages/respo…

Microsoft Forms

forms.cloud.microsoft
6
1
13
2,399
Williams Lab retweeted
Leukaemia UK
@LeukUK19 Oct 2023
What if we could exploit one of the proteins driving AML? Could we cut off #leukaemia’s energy source and uncover new ways to treat the disease? ⚡ Meet Dr Noelia Che from @ucl, who is using her 2023 John Goldman Fellowship to find out! 👉 leukaemiauk.org.uk/research-…
3
1
7
1,282
Meet our amazing Post-Doc Dr. Noelia Che @noelia_che 👏
Leukaemia UK
@LeukUK19 Oct 2023
What if we could exploit one of the proteins driving AML? Could we cut off #leukaemia’s energy source and uncover new ways to treat the disease? ⚡ Meet Dr Noelia Che from @ucl, who is using her 2023 John Goldman Fellowship to find out! 👉 leukaemiauk.org.uk/research-…
13
714
Thanks to session chairs @Richardson_S_E and @WilliamsLabUCL . We missed you @MariaTeresaEs
2
10
555
Throwback from #KindPhilipp2023 in #Wilsede looking forward to see you all next year at #KindPhilipp2024
3
12
820
Williams Lab retweeted
andi roy@andiroy3 Jun 2023
A conference like no other! #KindPhilipp2023 Congratulations to @rolf_marschalek @JhKmann Olaf H and Martin Stanulla for organising such an amazing meeting.
2
5
21
2,023
Great to be back in Wilsede. @rolf_marschalek is opening #KindPhilipp2023. We are looking forward to 4 days filled with great science from @Jeremias_lab @florian_grebien @Menendez_Lab @andiroy @ChrBraun02141 @WilliamsLabUCL @Ullrich_Lab @HannahUckelmann and many others. – at Bispingen, Germany
2
6
28
2,204
Interested in starting a PhD in child health? We have fully funded Child Health research PhD studentships available. Application deadline: 9 January 2023. Find out more: ucl.ac.uk/child-health/study… @UCLPopHealthSci @DNP_ICH @DBC_ICH @GGM_ICH @ich_ppp @GreatOrmondSt
Apply for fully funded Child Health research PHD studentships at UCL Great Ormond Street Institute of Child Health

ALT Apply for fully funded Child Health research PHD studentships at UCL Great Ormond Street Institute of Child Health

11
6
📢Interested in studying the effect of radiation treatment on the #TME and how to combine radio and immune therapies for #childhoodCancer: Come and join our team @uclcancer @RadNetCRUKCoL Don't hesitate to contact me if you want to know more. ucl.ac.uk/work-at-ucl/search…

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk
6
3
Williams Lab retweeted
andi roy@andiroy3 Dec 2022
We have two postdoctoral positions available in our lab, to study #childhoodALL, funded by @NIH and @The_MRC . Join our team in beautiful Oxford @MRC_WIMM @OxPaediatrics @UniofOxford . Link below for more details, and happy to chat! my.corehr.com/pls/uoxrecruit…
15
2
30
Load more