Studying liver and biliary fibrosis and mechanics at the University of Pennsylvania @PennMedicine @pennbioeng @CEMB_STC
University of Pennsylvania
Joined August 2019
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From the Wells Lab this week in PNAS, work from @AbigailLoneker on the mechanical impacts of lipid droplets in hepatocytes. pnas.org/doi/10.1073/pnas.22…
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We show that lipid droplets indent the nucleus, reducing HNF4alpha expression proportionally to the deformation, that the accumulation of lipid shrinks nuclear volume and condenses chromatin, and that lipid droplets prevent alignment of actin and reduce cell traction forces.
Our collaborators in the @ShenoyLab developed two mathematical models that indicate that physical interactions between lipid droplets and other cell components can explain our experimental findings.
From postdoc #DavidLi, a new method to quantify bulk and local tissue stiffness in the same region that shows local fat accumulation leads to softening in fatty livers. biorxiv.org/content/10.1101/…
From grad student @AbigailLoneker, experimental and modelling work showing that lipid droplets mechanically indent the hepatocyte nucleus, disrupt cytoskeletal organization, and promote dedifferentiation. biorxiv.org/content/10.1101/…
Excited to share our new preprint on the role of versican in regulating the mechanics and organization of collagen matrices. @DongningChen biorxiv.org/content/10.1101/…
WellsLab retweeted
Meet @JessLlewellyn89, a postdoc in the @Wells_Lab who works on better understanding Biliary Atresia #showyourstripes #RareDiseaseDay #matrixbiology
Keep your eyes peeled for his mini-review entitled “A Modular Analysis of Bile Canalicular Function and its Implications for Liver Cholestasis.” @penngihep
WellsLab retweeted
Potential role for EFEMP1 in biliary atresia?
Efemp1 modulates elastic fiber formation and mechanics of the extrahepatic bile duct biorxiv.org/content/10.1101/…
@Wells_Lab
New work from @CEMB_STC! In collaboration with the @ShenoyLab and Paul Janmey, Graduate Student Dongning Chen investigated the impact of GAGs on cell-matrix interactions in a collagen rich environment
Happy to share a new preprint led by Xingyu Chen. We theoretically and experimentally show GAGs significantly affect the mechanical interactions between cells in tissues by altering the organization and alignment of the collagenous extracellular matrix. biorxiv.org/content/10.1101/…
Congratulations to postdoc @JessLlewellyn89, who won a poster presentation award at the Extracellular Matrix in Rare Disease meeting of the British Society for Matrix Biology
Check out the latest from visiting Fulbright Scholar Iris deJong: a beautiful graphical overview on the heterogeneity of the biliary tree. sciencedirect.com/science/ar…
We welcome manuscripts and reviews for a new special issue in @FrontiersIn MechEng, Physics, Physiology, MolecBiosci, "The Mechanobiology of Collagen Remodeling in Health and Disease". Please submit today! frontiersin.org/research-top…
Excited to share our latest preprint investigating the role of matrix proteoglycans on collagen fibrillogenesis and cell-mediated ECM reorganization. biorxiv.org/content/10.1101/… @CEMB_STC @Pennbioeng
Bioengineering graduate student Dongning Chen and collaborators focused on comparing the impact of small leucine-rich and large matrix proteoglycans, and found that specific proteogylcans have distinct effects on collagen fibrillogenesis and cell-mediated compaction.