@WeiLuLab

Neuroscientist, GABAergic synapses, GABA-A receptors, behavior and cognition

 Shenzhen, China
Joined February 2017
  • Tweets52
  • Following83
  • Followers220
1Media
Our paper on the critical role of Neuroligin 2 in social behaviors and OCD has been published at @SfNJournals early release. Thanks @WeiLuLab and team for their hard work and support! A critical role of Neuroligin 2 C-terminus in OCD and social behavior jneurosci.org/content/early/…
5
3
1
20
1,180
Congrats, Guohao!!! Thank you, @ghwang85 and the team！@dcast421 @AngeloKeramidas @Martin17436419 @wenyan_han @MiriamERM and X-less Shixiao Peng, Qingjun Tian, Lijin Dong and Yan Li! 10.1016/j.cell.2024.09.006 cell.com/cell/fulltext/S0092…

The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

Identification of TMEM132B as a GABAAR auxiliary subunit that modulates alcohol action in the brain at both the molecular and behavioral levels.

cell.com
ghwang85@ghwang851 Oct 2024
Very happy to share our recent work that shows a new transmembrane protein, TMEM132B, binding to GABA-A receptors and regulating alcohol-related behaviors @WeiLuLab doi.org/10.1016/j.cell.2024.…
2
1
9
1,960
Now online! The TMEM132B-GABAA receptor complex controls alcohol actions in the brain dlvr.it/TDtjDF
6
1
22
9,028
Researchers discovered that chronic stress disrupts a brain pathway, increasing anxiety, but blocking a key protein in this pathway reversed anxiety symptoms in mice. dlvr.it/TBvDrD

Scientists uncover biological pathway that could revolutionize anxiety treatment

Researchers discovered that chronic stress disrupts a brain pathway, increasing anxiety, but blocking a key protein in this pathway reversed anxiety symptoms in mice.

psypost.org
1
14
1
37
3,555
Thrilled to announce our publication in @PNASNews! We've uncovered a key stress-responsive signaling pathway manifesting anxiety and depression, paving the way for novel therapeutics development. Huge thanks to my amazing mentor @WeiLuLab and the team. pnas.org/doi/10.1073/pnas.24… ,
19
7
1
40
5,129
So excited that this study is finally out in @NeuroCellPress! @AliciaYChe @amandambuch @Ben_S_Huang @TedSchwartz13 authors.elsevier.com/a/1g9qX…
Weill Cornell Medicine@WeillCornell28 Nov 2022
Gene mutation linked to autism spectrum disorder drives changes in neuronal connection patterns, which could lead to abnormal behaviors, suggests a new preclinical study by a team from @WCM_CNG. bit.ly/3VgLcgq
3
1
12
#PLOSBiology: Sleep and wake cycles dynamically modulate hippocampal inhibitory synaptic plasticity dx.plos.org/10.1371/journal.… In this work we @Martin17436419 @wenyan_han show a wake-specific enhancement of inhibitory synaptic plasticity at PV-synapses onto CA1 pyramidal neurons.
1
5
19
Thanks Angelo for your critical contributions!
This Post is from an account that no longer exists. Learn more
1
3
Check out our new biorxiv paper led by @JJSherryWU and @ekfishy targeting the breadth of cortical somatostatin cells and showing their remarkably selective circuitry. biorxiv.org/content/10.1101/…

Cortical somatostatin interneuron subtypes form cell-type specific circuits

The cardinal interneuron classes are a useful simplification of cortical interneuron diversity, but such broad subgroupings glosses over the molecular, morphological, and circuit specificity of...

biorxiv.org
2
25
5
109
We have a postdoctoral position available at NINDS, NIH to study GABA-A receptors and GABAergic synapses. Please contact me if you are interested! Please retweet!
29
2
39
Wei Lu retweeted
Yi Gu@Guyiguyi18 May 2022
My lab @NINDS (research.ninds.nih.gov/gu-la…) is looking for highly motivated postdocs interested in the neural basis of spatial cognition! Please spread the word and recommend good candidates. Thank you! :)
2
7
1
18
Congrats! In this study we have generated a knockin mouse line and shown a critical role of S405 of Shisa7, a GABAA receptor auxiliary subunit, in inhibitory transmission and neurodevelopmental behaviors
This Post is from an account that no longer exists. Learn more
1
15
Thrilled to share our new paper published with @SpringerNature in @molpsychiatry , where we demonstrate the contribution of a specific subunit of GABAARs in syndromic intellectual disability. rdcu.be/cG34E
6
5
39
Shisa7-dependent regulation of GABAA receptor single-channel gating kinetics biorxiv.org/content/10.1101/… Congrats David @dcast421, a tremendous amount of work!

Shisa7-dependent regulation of GABAA receptor single-channel gating kinetics

GABAA receptors (GABAARs) mediate the majority of fast inhibitory transmission throughout the brain. Although it is widely known that pore-forming subunits critically determine receptor function, it...

biorxiv.org
2
7
24
Also appreciate the help from Angelo @AngeloKeramidas, a leading expert in single channel biophysics!
1
2
Great work , Kunwei @Martin17436419 and Ryan @DrRDShep !
Ryan Shepard@DrRDShep4 Aug 2021
New pre-print from @WeiLuLab
1
8
Congrats, Kunwei!
Ryan Shepard@DrRDShep29 Mar 2021
Newest work by @WeiLuLab by @Martin17436419 @wenyan_han! 🎊 🎉 Activity- and sleep-dependent regulation of tonic inhibition by Shisa7 sciencedirect.com/science/ar…
6
Excited to share with you our recent review in TINs @TrendsNeuro by @amahan0805 and @DrRDShep! Regulation of GABAARs by Transmembrane Accessory Proteins cell.com/trends/neuroscience…
2
4
1
27
A new signaling mechanism regulating neuroligin2 at GABAergic synapses
Josef Kittler@JosefKittler28 Jul 2020
New pre-print from the lab in collaboration with @saad_hannan and the Smart lab from @uclnpp : PKA-mediated phosphorylation of Neuroligin-2 regulates its cell surface expression and synaptic stabilisation biorxiv.org/content/10.1101/…

PKA-mediated phosphorylation of Neuroligin-2 regulates its cell surface expression and synaptic...

The trans-synaptic adhesion molecule Neuroligin-2 (NL2) is essential for the development and function of inhibitory synapses. NL2 recruits the postsynaptic scaffold protein gephyrin, which in turn...

biorxiv.org
2
Load more