@WardLab1

A structural bio lab using electron microscopes to study HIV, Ebola, Flu, Malaria, Coronaviruses, and membrane proteins. Views are our own.

 San Diego
ward.scripps.edu
Joined June 2018
  • Tweets382
  • Following232
  • Followers2.8K
77Media
Congratulations to new @NSF #GRFP fellows: Gabrielle in the @MGClab, Jared in the lab of Luke Lairson, @alexxsaladbar in the @LanderLab, Leigh in the @WardLab1 and Noah in the @disney_lab!
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Holding it together: Nanoparticle stabilization of LASV trimer. @bmgunn31 examines work of @AA_Lab_EPFL @WardLab1 using two-component nanoparticle strategy that enables stable trimeric presentation of #Lassavirus glycoprotein complex & induction of bnAbs cell.com/cell-host-microbe/f…

Holding it together: Nanoparticle stabilization of LASV trimer

The development of Lassa virus (LASV) vaccines has been challenging due to the instability of recombinant immunogens. In this issue of Cell Host & Microbe, Brouwer et al. use a two-component nanopa...

cell.com
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Featured Article: Lassa GPC nanoparticles- path to a vaccine? Stabilized #Lassa virus glycoprotein nanoparticle vaccine induces potent #antibody responses in rabbits & protects guinea pigs from #Lassavirus challenge @WardLab1 @AA_Lab_EPFL Brouwer & Sanders cell.com/cell-host-microbe/f…
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New in Science: Researchers have determined the cryo–electron microscopy structure of the hepatitis C virus E1E2 glycoprotein complex. The structure provides a blueprint for the design of vaccines and drugs that target the virus. scim.ag/jP
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A new endowed fund set up by Prof. Andrew Ward is helping up-and-coming scientists from under-represented backgrounds to enroll in university without the worries of financial insecurity. Congratulations to inaugural recipient Alesandra Rodriguez magazine.scripps.edu/profile… @WardLab1

Freeing up young minds to pursue their dreams in STEM - Scripps Research Magazine

A new endowed fund at Scripps Research is helping up-and-coming scientists from under-represented backgrounds to enroll in university without the constant worries of financial insecurity.

magazine.scripps.edu
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Two studies from Prof. Bill Schief’s lab & collaborators describe an approach to design a custom HIV vaccine that can coax the immune system to produce the right broadly neutralizing antibodies in a stepwise manner scripps.edu/news-and-events/… @ImmunityCP @ragoninstitute @moderna_tx
structural image of an antibody

ALT structural image of an antibody

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The Ward Lab retweeted
Eric Topol
@EricTopol29 Sep 2022
And here's a short video what we're doing for a universal, variant-proof Covid vaccine, via joint efforts of immunology and structural biology, with @DennisRBurton and Ian Wilson, @WardLab1 youtube.com/watch?v=O2d8jG7b…

The search for universal vaccines: Coronavirus

Scientists at Scripps Research are working to develop universal vac...

youtube.com
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Many scientists are working toward the gold standard of infectious disease prevention: universal vaccines. But what does that mean? A quick intro! (& as always, a huge shoutout to Matt, Faith, and Drew—teamwork makes the dream work!) @scrippsresearch youtube.com/watch?v=1ROgFuDo…
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The Ward Lab retweeted
Tom Caniels@tomcaniels5 Aug 2022
Many months & edits later, our work on the baseline SARS-CoV-2 spike-reactive B cell repertoire is (finally!) out in @NatureComms. ⬇ Most interesting & relevant results below. It gets cool. ⬇ @vanGilsLab nature.com/articles/s41467-0… (1)

A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike

Nature Communications - To fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and...

nature.com
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The Ward Lab retweeted
Tom Caniels@tomcaniels5 Aug 2022
With the help of the very talented @julianna_han @WardLab1, we found out that this IGHV1-69/IGKV3-11 B cell pairing exclusively targets an apical S2 domain, which is normally obscured on the prefusion spike trimer but might be present in open and/or aberrant conformations. (8)
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The Ward Lab retweeted
ZackB
@zacharyberndsen30 Jun 2022
I am excited to share work from my postdoc at @WardLab1 on visualizing glycan structure with cryo-EM next Thursday. The talk is open to the public so tell your friends! @MizzouEMC can also put the word out to interested parties :)
Open Box Science@OpenBoxSci30 Jun 2022
OBS Seminar: "Visualizing Glycan Structures" ⏰10AM ET July 7th 2022 📢 Speakers: Danny Hsu @AcadSinica and Zachary Berndsen @scrippsresearch Moderated by: Kelvin Anggara @maxplanckpress 👉Registration: us02web.zoom.us/meeting/regi… #OpenScience #cryoem #infectiousdiseases
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The Ward Lab retweeted
Jarrod Mousa@jjmousa15 Jun 2022
Kaito Nagashima's (grad student) paper on H1 HA antibodies targeting broadly reactive immunogens is online! Great collaboration with Ted Ross, @WardLab1, and @TheDuBoisLab! @CivrHrp @niaidcivics @ugacvi @UGA_IDIS @ugavetmed. jimmunol.org/content/early/2…
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The Ward Lab retweeted
The Ward Lab@WardLab123 May 2022
Exciting new flu work from Julianne + the Wilson lab and @florian_krammer shows that chimeric HA universal flu antigens are flexible and present a broadly protective trimer interface epitope. Read all about it - pnas.org/doi/10.1073/pnas.22…

Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the...

Influenza virus hemagglutinin (HA) has been the primary target for influenza vaccine development. Broadly protective antibodies targeting conserved...

pnas.org
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New, really cool CIVICs study with Ian Wilson and @WardLab1 showing that our cHA constructs support binding of HA stalk AND trimer interface antibodies! @niaidcivics pnas.org/doi/10.1073/pnas.22… Below: Structure of cH15/3 with FluA-20 and stalk mAb bound!
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Great collaboration with @WardLab1. Special thanks goes to #AndrewWard, @GabeOzorowski and #JohnTorres for their amazing structural work on J08, our antibody tested in phase II/III clinical trial for the treatment of COVID-19. Kudos guys and congratulations to us all!
Sarah C.P. Williams@sarahcpwilliams13 May 2022
The antibody J08 can recognize many COVID-19 variants. Now @WardLab1 @GabeOzorowski at @scrippsresearch reveals in @PNASNews how the antibody's structure makes it so potent and flexible, and what that means for future viral variants. scripps.edu/news-and-events/…
Even as the structure of SARS-CoV-2 changes with different variants of the virus (gray), the J08 antibody (blue) can still bind it.

ALT Even as the structure of SARS-CoV-2 changes with different variants of the virus (gray), the J08 antibody (blue) can still bind it.

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The antibody J08 can recognize many COVID-19 variants. Now @WardLab1 @GabeOzorowski at @scrippsresearch reveals in @PNASNews how the antibody's structure makes it so potent and flexible, and what that means for future viral variants. scripps.edu/news-and-events/…
Even as the structure of SARS-CoV-2 changes with different variants of the virus (gray), the J08 antibody (blue) can still bind it.

ALT Even as the structure of SARS-CoV-2 changes with different variants of the virus (gray), the J08 antibody (blue) can still bind it.

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Studying the serum of patients recovered from COVID-19, @WardLab1 have discovered that antibodies exposed to SARS-CoV-2 can also recognize spike proteins of other coronaviruses, such as the common cold scripps.edu/news-and-events/… @ScienceAdvances
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COVID-19 might, at least temporarily, boost the number of antibodies you have against common cold-causing coronaviruses. @WardLab1 at @scrippsresearch characterized these antibodies today in @ScienceAdvances. scripps.edu/news-and-events/…

How a COVID-19 infection spurs antibodies against common colds - Scripps Research

Scripps Research scientists analyzing coronavirus antibodies found more antibodies that recognize other, related viruses in people who had been infected with COVID-19.

scripps.edu
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After finishing his thesis research in the @WardLab1, Sebastian Jojoa-Cruz is now investigating the design of synthetic #MembraneProteins as a postdoc in the @scrippsresearch lab of Marco Mravic. Read about Sebastian and our other 2022 PhD recipients at: scripps.edu/2022grads
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Authors @MurthySE, @ardemp , @WardLab1 from @scrippsresearch characterize Flycatcher1 (FLYC1), a candidate mechanosensitive channel involved in Venus flytrap touch-induced prey capture. #cryoEM #Mechanosensitive #IonChannel go.nature.com/3tmMyKp
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