@WangyrRay
 San Francisco, CA
Joined April 2016
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From my baymate - exciting stuff!
Eliza Nieweglowska@ENieweglowska7 Apr 2022
Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice! biorxiv.org/content/10.1101/…

The ϕPA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice

A growing number of jumbo bacteriophages, with genomes exceeding 200 kb, have been found to establish a Phage Nucleus—a micron-scale, proteinaceous structure encompassing the replicating phage DNA....

biorxiv.org
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Our structure of an active Janus Kinase-Cytokine Receptor dimer is out in @ScienceMagazine. We found a dimerization interface between apposing pseudokinase domains that is stabilized by oncogenic Val-Phe mutation resulting in ligand-independent activation science.org/doi/10.1126/scie…

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

The cryo–electron microscopy structure of the JAK1 cytokine receptor complex reveals a mechanism of dimeric activation exploited by oncogenic mutation.

science.org
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And every journal wants something different @OpenAcademics @AcademicChatter #academictwitter
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The academic job market
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The mean age of men and women receiving their first R01 is now 44 years of age. We need to ask ourselves why and how we can change this. This is a decade or more behind many entrepreneurs.
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Ray Wang retweeted
T3SS@T3SS227 Oct 2021
Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome pnas.org/content/118/44/e211…

Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injecti...

Type III secretion systems are multiprotein molecular machines required for the virulence of several important bacterial pathogens. The central ele...

pnas.org
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an example of hydrogen bonding between Tyr53 and Asp66. The hydrogen density is found at the center of the ~2.8A hydrogen bond length between the CO of tyrosine and the CO of the Aspartate. Other hydrogens are not shown in this image for clarity
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Density for every amino acid at this resolution below
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We investigated millions of potential protein-protein interaction pairs in yeast by modeling them with RoseTTAFold and AlphaFold. Check out some of neat the interactions from dimers to pentamers that we found: biorxiv.org/content/10.1101/…

Structures of core eukaryotic protein complexes

Protein-protein interactions play critical roles in biology, but despite decades of effort, the structures of many eukaryotic protein complexes are unknown, and there are likely many interactions...

biorxiv.org
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Don't ever question a @UCSF grad student about why we need a union. This is the lowest hanging fruit. Get paid on time. Every month. THIS FUCKING HAPPENS TO STUDENTS EVERY MONTH.
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Can someone introduce me to the pool of postdocs who have extensive experience running a research group, writing grants, publishing senior author papers, and designing and teaching classes so we can only hire people who have a proven track record of doing this job?
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This is why it matters to disaggregate the data for Asian groups in the US. Considering all AAPIs together hides enormous variations in income and education nytimes.com/interactive/2021…
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For those who don’t know - the guy playing the piano discovered protein phosphorylation
Élyse Fischer@ElyseFischer714 Aug 2021
I want to share with Twitter a very special moment. My grandfather Eddy Fischer, 101 years old, playing piano at my brothers wedding, two weeks ago.
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Several immensely talented postdocs will be leaving our lab within the next year. I wanted to make it clear (to folks involved in selection/grants committees) that they all *own* the work they've done here & they'll take it *all* with them, of course (it's theirs!).
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Google, what the hell is this?
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#cryoEM of insect odorant-gated ion channel in multiple states — apo or bound to 2 agonists, insect repellent DEET and odorant eugenol Work by Ruta lab @RockefellerUniv @nature nature.com/articles/s41586-0… With NV by @emily_liman nature.com/articles/d41586-0…

The structural basis of odorant recognition in insect olfactory receptors

Nature - Structural and functional analysis of an insect olfactory receptor shed light on how receptors can be activated by diverse odorants.

nature.com
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After 2 weeks of working together intensively, we proudly present our assessment of using #alphafold2 from @DeepMind for peptide-protein docking: it works! biorxiv.org/content/10.1101/… 🧵

Harnessing protein folding neural networks for peptide-protein docking

Highly accurate protein structure predictions by the recently published deep neural networks such as AlphaFold2 and RoseTTAFold are truly impressive achievements, and will have a tremendous impact...

biorxiv.org
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Today with @emblebi, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: dpmd.ai/alphafolddb 1/
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