Neurodegeneration Pathobiology Lab studying TDP-43, on a mission to cure #MND #ALS & #FTD. Led (and most tweets) by @adamkeithwalker. @QldBrainInst, @UQ_News.
Beautiful Brisbane, Australia
Joined March 2017
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Very happy to see our collaborative project led by @Rebecca_SanGlia with @adamkeithwalker out today in @NatureComms, tracking proteomic changes in the cortex throughout disease in TDP-43 mice with comparison to human #ALS #FTD doi.org/10.1038/s41467-024-4…
TDP-43-mediated neurodegeneration is complex. We show that prior to disease onset in a mouse model of ALS/FTD, cortex neurons elicit a transient increase in protective chaperones that combat TDP-43 aggregation. Read it @NatureComms:
rdcu.be/dy1PM
Walker Neuro Lab retweeted
The @dehorterlab is excited to share a new study demonstrating a causal link between #immune activation, #alphasynuclein and #Parkinson onset.
This work establishes the first immune-induced model to investigate the prodromal phase of idiopathic #Parkinson.
@QldBrainInst @JCSMR
Alpha Synuclein Induced Immune Response Triggers Parkinson's Disease Like Symptoms biorxiv.org/cgi/content/shor… #biorxiv_neursci
Walker Neuro Lab retweeted
Today would have been Justin's 50th birthday, but as many of you know, Justin passed away last year after a long battle with MND
This weekend the Yerbury lab are taking part in the walk to defeat MND to raise vital funds to support those living with MND ⬇️
walktodefeatmnd.org.au/fundr…
Walker Neuro Lab retweeted
Excellent piece on frontotemporal dementia by @AmyBrodtmann.
Watch Dementia Australia Honorary Medical Advisor Prof Amy Brodtmann MBBS, FRACP, PhD in an on-demand webinar about frontotemporal dementia, discussing the symptoms, strategies, and support available for those impacted by FTD.
Watch now at youtu.be/sD0XpAJ1s0o?si=HA7b…
Walker Neuro Lab retweeted
SAVE THE DATE!
We will be holding the 3rd Australian and New Zealand MND Research Symposium in Melbourne on Tuesday 27th and Wednesday 28th of August.
An MND Connect session will also run on the Wednesday.
Further information to come as we progress with the event.
This is sad news on the outcomes of the pivotal phase 3 trial of AMX0035, which did not meet any of the primary or secondary outcome measures for people living with ALS/MND. Next steps unclear, but there are many more treatments in testing which will hopefully be more positive.
Today, we shared the topline results from our Phase 3 PHOENIX trial. Read more in our press release: bit.ly/3TbILMC
On behalf of the entire Amylyx team, we are grateful to the ALS community and for the dedication of trial participants, investigators, and study site teams. With data collected from 664 participants in PHOENIX, we are certain there will be important learnings that will help inform future ALS research.
Walker Neuro Lab retweeted
Trikafta — a triple small molecule combo therapy — can be considered functionally curative, though variant specific top-ups are still in play.
More of this please!
Walker Neuro Lab retweeted
World-renowned scientist Dr. Virginia Man-Yee Lee at @PennMedicine has made groundbreaking contributions to our understanding of tau, earning her the 2024 #RainwaterPrize for Outstanding Innovation in Neurodegenerative Research, to be awarded at #Tau2024. rainwatercharitablefoundatio…
Walker Neuro Lab retweeted
"We found several proteins that were driving disease forward and making it worse... we also found proteins that are increased early in disease and are protective."
@QldBrainInst researcher @Rebecca_SanGlia explains how her protein map could offer therapeutic pathways for #MND.
This work first initiated with support from @MND_RIA, and with vital further support from @FightMND, @racingdementia, @DementiaAus along with @nhmrc and fantastic donors to @QldBrainInst - our research couldn’t be done without it.
Kicking goals @elise_kellett!
Toxic clumps of a protein called TDP-43 are found in 97% of #MND #ALS cases.🔬
Elise Kellett has shown that toxic TDP-43 can stop other proteins from working correctly.
Investigation of the specific pathways affected could lead to new treatments.⬇️
mndresearch.blog/2024/01/18/…
Congrats @elise_kellett - doing the lab proud!
Congratulations to @elise_kellett, who received the Joan Lawrence Endowment Prize for High Achieving Women in Neuroscience. 💜
Elise is currently doing her #PhD in the @WalkerNeuroLab at the @QldBrainInst, researching potential therapeutic interventions in Motor Neuron Disease.
Walker Neuro Lab retweeted
Congratulations to @elise_kellett, who received the Joan Lawrence Endowment Prize for High Achieving Women in Neuroscience. 💜
Elise is currently doing her #PhD in the @WalkerNeuroLab at the @QldBrainInst, researching potential therapeutic interventions in Motor Neuron Disease.
Just out - Jane Simpson has a chat with @adamkeithwalker about MND research and why there is cause for hope, on Jane's new podcast 'Let's Talk MND' open.spotify.com/episode/0vD…
Walker Neuro Lab retweeted
@TrendsNeuro 'Spotlight' by Matisse Jacobs, Rebecca San Gil & Adam Walker @WalkerNeuroLab
sciencedirect.com/science/ar…
discussing Guo et al. 2023 ‘Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies’
nature.com/articles/s41422-0…
Walker Neuro Lab retweeted
Want to deliver gene therapies broadly, but activate them only in diseased neurons?
TDP-REG "hacks" TDP cryptic mis-splicing to drive expression only WHEN and WHERE needed! Less toxicity, wider therapeutic window, new options for sporadic ALS therapies.
biorxiv.org/content/10.1101/…
Thank you to @FightMND and all the supporters for giving a thumbs up to our new collaborative project @QldBrainInst with @adamkeithwalker @samkbarton7 @Rebecca_SanGlia @DrCarlieCullen @DrCathBlizzard and co! We are eager to get started!
Introducing our third grant recipient of 2023, Dr. @adamkeithwalker from @UQscience. His project ‘Oligodendrocytes and TDP-43 pathology in MND' aims to unlock the causes and disease mechanisms of MND. We're so lucky to support the best and brightest researchers in Aus.
Walker Neuro Lab retweeted
Join us on 24 October at 12pm AEDT to hear about how patient registries are helping to accelerate clinical discoveries in MND research.
Register at: fightmnd.org.au/fightmnd-sci…
Walker Neuro Lab retweeted
Super proud of @JulieNecNeuro for the long journey and the massive amount of work that went into this paper. You will be missed!
Our paper is (finally) officially published! Check out our work showing that acetylation-mimic TDP-43 impairs RNA regulation, alters protein localization and solubility, and induces behavioral deficits in aging mice. doi.org/10.7554/eLife.85921.… (1/2)
Abstracts closing Oct 5 for the conference on cellular and molecular neurodegeneration #CAMAND23, to be @QldBrainInst on Dec 3-4, 2023! camand.org
Prizes and travel awards for students and ECRs - get in quick!
Last chance to get your abstracts in for #CAMAND23 conference!!
Only 2 days before abstract submission closes
Submit at camand.org/ by 5pm, Thursday Oct 5th
@DrEleanorD @DannyHatters @MargaretSunde @anthonyjhannan