M.D. with Kidneys & Vasculitis as major activity field. Practicing Plasma Exchange. Foodie & food traveller. The Life is painted by one of my patients.
Copenhagen Rigshospitalet
Joined April 2009
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Wladimir Mietek Szpirt retweeted
👇🏼
Please join us to meet international experts in glomerular diseases during @ERAkidney IWG CME Course, 16-17.10.2026 in Łódź. Full program available 👉🏻 nephrology-conference.fumed.… @AKronbichler @ewa_pawlowicz @smirioglu @AnnetteBruchfe1 @StefanieSteige6 @Tobias_B_Huber @KateIsabelle24
Wladimir Mietek Szpirt retweeted
Our new article Multi-omics of kidney biopsies in ANCA-associated GN:
🔹 Complement activation precedes visible glomerular injury
🔹 Monocytes dominate the infiltrate
🔹 Novel TRIM21/25 axis + noncanonical IFN signaling
🔹 PD-L1 checkpoint failure
doi.org/10.1002/acr2.90114
Wladimir Mietek Szpirt retweeted
🌟 Join us for the 64th episode of A pinch of salt for an in-depth conversation with David Jayne on the evolving landscape of ANCA-associated vasculitis.
🎙️ We explore the shift from the traditional cyclophosphamide + glucocorticoid approach to biologics like rituximab and emerging targeted therapies, including avacopan, highlighting how clinicians balance efficacy, safety, and quality of life.
🎧 Listen now to gain insights into the future of treatment and what may define the next decade in care 👉 bit.ly/4koNiIv
Wladimir Mietek Szpirt retweeted
📣 Excited to get started at today’s meeting for @GlomCon Foundation’s Rare Kidney Disease Journal — a new peer-reviewed journal developed in partnership with Springer Nature; with Editor-in-Chief: Andreas Kronbichler
Link: link.springer.com/journal/44…
This initiative represents an important step toward building a dedicated global platform for rare and complex kidney diseases, uniting investigators, clinicians, pathologists, geneticists, and innovators across disciplines. Looking forward to shaping a journal that advances rigorous science, meaningful collaboration, and real impact for patients worldwide.
The future is bright.
Wladimir Mietek Szpirt retweeted
Top 100 Best Hospitals in the World (2025)
1. 🇺🇸 Mayo Clinic – Rochester
2. 🇺🇸 Cleveland Clinic
3. 🇨🇦 Toronto General – University Health Network
4. 🇺🇸 The Johns Hopkins Hospital
5. 🇸🇪 Karolinska Universitetssjukhuset
6. 🇺🇸 Massachusetts General Hospital
7. 🇩🇪 Charité – Universitätsmedizin Berlin
8. 🇮🇱 Sheba Medical Center
9. 🇸🇬 Singapore General Hospital (SGH)
10. 🇨🇭 Universitätsspital Zürich
11. 🇫🇷 AP-HP – Hôpital Universitaire Pitié Salpêtrière
12. 🇨🇭 Universitätsspital Basel
13. 🇺🇸 Ronald Reagan UCLA Medical Center
14. 🇩🇪 Universitätsklinikum Heidelberg
15. 🇨🇭 Centre Hospitalier Universitaire Vaudois
16. 🇯🇵 The University of Tokyo Hospital
17. 🇺🇸 Stanford Health Care – Stanford Hospital
18. 🇩🇰 Aarhus Universitetshospital
19. 🇺🇸 The Mount Sinai Hospital
20. 🇩🇰 Rigshospitalet – Copenhagen University Hospital
21. 🇺🇸 Brigham and Women’s Hospital
22. 🇧🇷 Hospital Israelita Albert Einstein
23. 🇩🇪 LMU Klinikum
24. 🇨🇦 Sunnybrook Health Sciences Centre
25. 🇰🇷 Asan Medical Center
26. 🇫🇷 CHU Lille – Hôpital Claude-Huriez
27. 🇦🇹 AKH Wien / Medical University of Vienna
28. 🇳🇴 Oslo Universitetssykehus
29. 🇫🇷 Hôpital Européen Georges Pompidou
30. 🇰🇷 Samsung Medical Center
31. 🇳🇱 Amsterdam UMC
32. 🇨🇦 Mount Sinai Hospital (Toronto)
33. 🇬🇧 St Thomas' Hospital
34. 🇺🇸 Cedars-Sinai Medical Center
35. 🇩🇪 Universitätsklinikum Hamburg-Eppendorf
36. 🇯🇵 St. Luke’s International Hospital
37. 🇮🇹 Grande Ospedale Metropolitano Niguarda
38. 🇺🇸 Northwestern Memorial Hospital
39. 🇺🇸 UCSF Medical Center
40. 🇧🇪 UZ Leuven
41. 🇩🇪 Medizinische Hochschule Hannover
42. 🇰🇷 Seoul National University Hospital
43. 🇫🇮 Helsinki University Hospital
44. 🇮🇹 Policlinico Universitario A. Gemelli
45. 🇩🇪 Klinikum rechts der Isar (TU Munich)
46. 🇰🇷 Severance Hospital – Yonsei University
47. 🇺🇸 University of Michigan Health
48. 🇳🇱 Erasmus MC
49. 🇪🇸 Hospital Universitario La Paz
50. 🇺🇸 Mayo Clinic – Jacksonville
51. 🇳🇱 UMC Utrecht
52. 🇪🇸 Hospital Universitario 12 de Octubre
53. 🇨🇭 Les Hôpitaux Universitaires de Genève (HUG)
54. 🇮🇹 Ospedale San Raffaele – Gruppo San Donato
55. 🇺🇸 Duke University Hospital
56. 🇦🇹 Landeskrankenhaus Innsbruck
57. 🇨🇦 North York General Hospital
58. 🇯🇵 Kameda Medical Center
59. 🇪🇸 Clínic Barcelona
60. 🇮🇱 Tel Aviv Sourasky Medical Center
61. 🇮🇹 Istituto Clinico Humanitas
62. 🇦🇺 Royal Prince Alfred Hospital
63. 🇺🇸 Hospital of the University of Pennsylvania
64. 🇳🇱 Radboud UMC
65. 🇨🇭 Klinik Hirslanden Zürich
66. 🇩🇪 Uniklinik Köln
67. 🇺🇸 Mayo Clinic Hospital – Phoenix
68. 🇰🇷 Seoul National University – Bundang Hospital
69. 🇸🇪 Sahlgrenska Universitetssjukhuset
70. 🇪🇸 Vall d'Hebron University Hospital
71. 🇫🇷 ELSAN – Santé Atlantique
72. 🇺🇸 Houston Methodist Hospital
73. 🇮🇹 Policlinico Sant'Orsola-Malpighi
74. 🇩🇪 Universitätsklinikum Freiburg
75. 🇫🇷 CHU Bordeaux – Pellegrin
76. 🇪🇸 Hospital General Universitario Gregorio Marañón
77. 🇺🇸 NewYork-Presbyterian Hospital – Columbia & Cornell
78. 🇳🇱 Leiden University Medical Center
79. 🇪🇸 Clínica Universidad de Navarra
80. 🇸🇬 National University Hospital (NUH)
81. 🇯🇵 Kyushu University Hospital
82. 🇸🇪 Akademiska Sjukhuset (Uppsala)
83. 🇧🇷 Hospital Sírio-Libanês
84. 🇬🇧 Guy’s Hospital
85. 🇩🇰 Odense University Hospital
86. 🇬🇧 University College Hospital (London)
87. 🇰🇷 Gangnam Severance Hospital
88. 🇬🇧 Addenbrooke’s Hospital
89. 🇨🇦 Montreal General Hospital – MUHC
90. 🇫🇷 Hôpital de la Timone (AP-HM)
91. 🇯🇵 Nagoya University Hospital
92. 🇨🇦 Centre hospitalier de l’Université de Montréal (CHUM)
93. 🇺🇸 NYU Langone Hospitals – Tisch Hospital
94. 🇦🇺 The Alfred (Melbourne)
95. 🇦🇹 Kepler Universitätsklinikum
96. 🇦🇺 Royal Melbourne Hospital – Parkville
97. 🇮🇳 All India Institute of Medical Sciences – Delhi
98. 🇯🇵 Keio University Hospital
99. 🇦🇹 Universitätsklinikum Graz
100. 🇹🇭 Bumrungrad International Hospital (Bangkok)
Note: Based on expert surveys, patient experience data, hospital quality metrics, and PROMs.
Source: NEWSWEEK and Statista
Wladimir Mietek Szpirt retweeted
In our new study in KI Reports we show how longitudinal monitoring of serum anti-podocin antibodies guided immunotherapy in a difficult case of steroid- and rituximab-resistant nephrotic syndrome sciencedirect.com/science/ar…
Wladimir Mietek Szpirt retweeted
Real-life use of PEXIVAS reduced-dose glucocorticoid regimen in granulomatosis with polyangiitis & microscopic polyangiitis
🔴 Retrospective multicentre
🔴 redGC vs standGC in AAV
🔴 1️⃣ composite outcome= death, ESKD, relapse
👉 redGC associated with ⬆️ risk of primary outcome
Wladimir Mietek Szpirt retweeted
TAPIR study of continuing vs stopping steroids in ANCA vasculitis in remission. Relapse at month 6 in 16% vs 4%. OR 4.22, but low rate in either group. If treated Rituximab, no difference! Merkel et al. @RheumNow #ACR24 Abstr#0774 #ACRbest acrabstracts.org/abstract/a-…
Wladimir Mietek Szpirt retweeted
“Nephro in Rio 2024” meeting organized by the
“Sociedade de Nefrologia do Estado do Rio de Janeiro” and the Mayo Clinic just started with more than 200 registrants from all over Brazil! @MayoClinicNeph @GlassockJ @AKronbichler
Wladimir Mietek Szpirt retweeted
Different mechanism! Once deposits are built up and impair podocyte function and adhesion in MN, removing antibodies does not have an immediate or even longer term effect. In MCD, the interference of the antibody is immediate and can also be immediately stopped! – at West Okoboji, IA
Wladimir Mietek Szpirt retweeted
But it has not evaluated the role of PLEX in DAH due to ANCA vasculitis sir.
Wladimir Mietek Szpirt retweeted
El resultado de PLEX en vasculitis por ANCA
🛑ERC o diálisis, sin 📏⚠️infeccion🦠
✔️Sin impacto en la recuperación de la función renal
#ISNWCN
Wladimir Mietek Szpirt retweeted
Cuántas sesiones de PLEX?
En la hemorragia alveolar 🫁
#️⃣sesiones, reposición albúmina o PFC, uso de cambios dinámicos en CrS y semilunas en 🔍biopsia renal
🤓Desde PEXIVAS 🔜#ISNWCN
Wladimir Mietek Szpirt retweeted
Nordic ANCA-associated Vasculitis Forum
Thursday, 7th March 2024
Interesting program at the FIRST Nordic AAV Forum in Copenhagen Airport, Denmark. My talk on interstitial lung disease in AAV. Nice to meet so many Scandinavian nephrologists, rheumatologists and pulmonologists.
Wladimir Mietek Szpirt retweeted
💥Just notified about two oral and one poster presentation at the @VasculitisBCN24 with a leading contribution from the Nephrology in Graz.
Can’t wait to discuss our topics on treatment outcomes and biomarkers in #AAV with the fabulous vasculitis community.
The 21st International Vasculitis Workshop will take place in Barcelona!
April 7-10th, 2024
Save the date‼️😉
vasculitis-barcelona2024.com…
Wladimir Mietek Szpirt retweeted
Just published in @ARD_BMJ (ard.bmj.com/content/early/20…) - risk of severe infections in #AAV. The prophylactic use of low-dose TMP/SMX may reduce this risk. A work I am really proud of. Many thanks to all my co-authors, especially to my friend @AKronbichler for his endless support!
Wladimir Mietek Szpirt retweeted
My doctors gave me a 1 in a million chance to find a cure to my disease.
To make things worse, I didn’t have a billion dollars and 10 years to develop a new drug from scratch.
My only hope was to find a drug that was already FDA-approved that I could repurpose for my disease.
It’s been over 9.5 years that I’ve been in remission and we have been able to identify and advance numerous treatments for diseases they weren’t initially intended for.
Now through @EveryCure we are utilizing artificial intelligence to maximize the potential of all existing drugs to treat every disease they possibly can.
What is a cause that you’re passionate about that people give a 1 in a million chance? #MedTwitter
Wladimir Mietek Szpirt retweeted
Did you miss the @ERAkidney e-seminar on
👉*Age and time-dependent increase in incident anti-glomerular basement membrane disease*
#tweetorial by @G_ErtanDemirtas
#NephTwitter #MedEd
Speaker @EmilNelveg
Moderators @VanAmaryllis @AKronbichler
👉 doi.org/10.1093/ckj/sfad261
Wladimir Mietek Szpirt retweeted
Repeat kidney biopsies! What are we missing? Active-to-chronic transition despite ‘effective therapy’, by @BrixSilke at the #ukivas meeting in Manchester!
Wladimir Mietek Szpirt retweeted
Abst#0725 #ACR23 @RheumNow
PEXIVAS Real life data!
GPA & MPA pts - Retrosp observ study
⭐️Reduced-dose GC regimen ass w/ INCREASED risk of death, ESKD, progression
Greatest risk: pt w Cr levels >300 umol/L, RTX induction Rx
⚠️Caution w/ reduced GC, RTX, severe kidney dis
#ACRBest
