@WHOCenterFrailt

IHU HealthAge - WHO Collaborating Center for Frailty, Clinical & Geroscience Research, and Geriatric Training

 CHU de Toulouse, France
Joined November 2018
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  • Followers3.2K
56Media
The effect of IC on health-related outcomes is influenced by frailty status. The sub-group analysis supported the detrimental effect of IC loss even among non-frail older adults. These findings support IC assessment alongside frailty evaluation. sciencedirect.com/science/ar…
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IC impairments, were associated with a higher risk of ER visits. Routine #ICOPE assessment in community and primary care settings may help identify at-risk older adults early and guide targeted, integrated interventions sciencedirect.com/science/ar…
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Low-dose aspirin had no effect on the rate of loss of healthspan among older community-dwelling adults. Future studies should explore lifestyle and behavioural interventions to extend healthspan. pmc.ncbi.nlm.nih.gov/article…

Effect of aspirin on healthspan in community-dwelling older adults: the ASPirin in reducing events...

Inflammation is a shared pathogenic pathway underlying multiple chronic conditions and contributes to a loss of healthspan. This study aimed to evaluate the effect of low-dose aspirin on the loss of...

pmc.ncbi.nlm.nih.gov
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These findings identify a mitochondrial metabolic checkpoint that enables the epigenetic execution of innate immune signalling, revealing a mechanism that selectively controls the inflammatory output of senescent cells. rdcu.be/fzSN1
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👏Congratulations to @YohanSantin - @I2mcT for their article Established and emerging roles of #lysosomal dysfunction in #cardiac #published in @NatureCVR doi.org/10.1038/s44161-026-0…

Established and emerging roles of lysosomal dysfunction in cardiac aging

Nature Cardiovascular Research - Santin et al. review the emerging role of lysosomes as central regulators of cardiac aging, highlighting their functions in coordinating metabolism, signaling and...

nature.com
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Proteomic clocks appear promising biomarkers of generalized age-related disease risk. rdcu.be/fzSMF
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Greater age gap, reflecting more advanced biological aging relative to chronological age, may serve as a driver associated with risk of early-onset solid cancers rdcu.be/fzSFA
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Join IHU HealthAge’s 1st WHO ICOPE bilingual webinar! Explore France’s ICOPE implementation: → National scale-up → Rural deployment → Age-friendly communities 📅 8 Sep 2026, 14:00–15:30 CEST 🌐 Online | French & English 🔗 Registration required: us02web.zoom.us/j/8595049979…
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Plasma proteomic signatures of cellular aging predict human disease rdcu.be/fwBSQ
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IC measures derived from routine assessments may provide a pragmatic approach for risk stratification and targeted interventions to promote healthy ageing. rdcu.be/fwBRG
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Intrinsic capacity could serve as an early marker of functional decline and guide the development of targeted interventions. @TheLancet Healthy Longevity thelancet.com/journals/lanhl…

Association between intrinsic capacity and disability before death among older adults: a decedent...

The association between intrinsic capacity and disability emerged approximately 14 years before death, suggesting that intrinsic capacity could serve as an early marker of functional decline and...

thelancet.com
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👏 Congratulations to @RouchLaure, @SoutoPhilipe & @RollandYves2 for their article Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity published in @JAMANetworkOpen jamanetwork.com/journals/jam…

Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity

This study from the INSPIRE-T Lifespan Translational Cohort evaluates whether accelerated epigenetic and inflammatory aging is associated with global intrinsic capacity, a multidomain measure of...

jamanetwork.com
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👏Congratulations to Marek Postula, Svjatoslavs Kistkins & all for their publication Delphi-derived Framework for Healthspan-Oriented Care: The Cardiometabolic Health Perspective in Agind and Disease @ISOAD2018 aginganddisease.org/EN/10.14…

Delphi-derived Framework for Healthspan-Oriented Care: The Cardiometabolic Health Perspective

This Delphi-derived expert consensus provides a clinical framework to optimize and maintain healthspan along the lifespan from the cardiometabolic health perspective in both healthy individuals and...

aginganddisease.org
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👏Congratulations to Antoine Cabrol & coll. for their article Feeling Younger as an Indicator of Better Overall Intrinsic Capacities in the INSPIRE-T Cohort @INSPIREPlatfor1 onlinelibrary.wiley.com/doi/…

Feeling Younger as an Indicator of Better Overall Intrinsic Capacities in the INSPIRE‐T Cohort

Objectives Existing literature indicates that subjective age—the age an individual feels or perceives themselves to be—is associated with various health outcomes. However, its relationship with...

onlinelibrary.wiley.com
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👏Congratulations to @matteo_cesari & coll for their article Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and transformation of care @brunovellas @DrYukaSumi academic.oup.com/ageing/arti…

Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and...

Abstract. As the global population ages, especially in low- and middle-income countries, there is an urgent need to rethink how health in older age is unde

academic.oup.com
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👏 Congratulations to I Tzu Chen for their article Intrinsic capacity evolution during aging in mouse and fish: Longitudinal perspectives from a narrative review @brunovellas @SoutoPhilipe sciencedirect.com/science/ar…
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👏Congrat's to Theodoula Adamakidou @uniwa_gr for their article Advancing healthy ageing in Greece: the WHO ICOPE protocol within the JA PreventNCD framework @tavassolineda rdcu.be/fiUQx
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👏 Congrat's to Natasha Grande de França for their article The role of dietary patterns on epigenetic and inflammatory aging based on the INSPIRE-T study publiseh in @CommsMedicine @SoutoPhilipe @brunovellas @RollandYves2 rdcu.be/fiUn9
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👏 Congrat's to @HsuanPenny for their article Screening high-risk older adults using self-assessed intrinsic capacity: evidence from real-world ICOPE implementation published in @Age_and_Ageing @isabelle_carrie @tavassolineda @SoutoPhilipe @brunovellas academic.oup.com/ageing/arti…

Screening high-risk older adults using self-assessed intrinsic capacity: evidence from real-world...

AbstractBackground. A basic assessment of intrinsic capacity (IC) deficits in the WHO Integrated Care for Older People (ICOPE) care pathway can be conducte

academic.oup.com
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From the USA : #Alzheimer's disease neuropathology plasma #biomarkers and #cognition in midlife: a community-based cohort study thelancet.com/journals/lance…

Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based...

Alzheimer's disease neuropathology is relatively uncommon in midlife but associated with worse cognitive performance and accelerated decline and might have stronger association among some groups....

thelancet.com
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