@WChengLab

Biophysical and structural studies of ligand-gated ion channels. Lipid modulation. @WUSTL_AnesRsrch Washington University Department of Anesthesiology

 Washington University
wchenglab.org
Joined August 2020
  • Tweets241
  • Following425
  • Followers617
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Structural mechanism of lipid modulation of pentameric ligand-gated ion channel activity biorxiv.org/content/10.1101/… #biorxiv_biophys

Structural mechanism of lipid modulation of pentameric ligand-gated ion channel activity

Pentameric ligand-gated ion channels (pLGICs) are sensitive to the lipid environment. However, the structural mechanism of how specific lipids support the agonist response of any pLGIC is poorly...

biorxiv.org
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Another paper from my postdoc with @CrinaNimigean on lipid modulation of an ion channel is out now. Great effort by @thon_oli further showcasing the value of a great model system. Congrats to the entire team! nature.com/articles/s41467-0…

PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK

Nature Communications - Thon et al. showed that the signaling lipid PIP2 inhibits a bacterial homolog of cyclic nucleotide-gated ion channels by binding between the voltage-sensing and pore domains...

nature.com
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I liked the reaction on the soundtrack/musical synopsis for our last paper, maybe every paper should have one. If you haven't seen/heard it yet, weekend is coming ! Paper @embojournal embopress.org/doi/full/10.10… Soundtrack by me and byteBBY @BebeByte on.soundcloud.com/sMNHNNSSdb…

Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel

The EMBO Journal - Multimeric membrane proteins are produced in the endoplasmic reticulum and transported to their target membranes which, for ion channels, is typically the plasma membrane....

link.springer.com
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Chakrapani_Lab@Chakrapani_lab21 Aug 2024
Join our team at Case Western Reserve University! #CWRUSOM #cryoEM #Ionchannels nature.com/naturecareers/job…

Postdoctoral position in Physiology and Structural Biology of Synaptic Receptors - Cleveland, Ohio...

Postdoctoral position in Physiology and Structural Biology of Synaptic Receptors

nature.com
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Baron Chanda@ChandaLab0619 Jun 2024
Structures of channels in Open conformation are rare. Thrilled to share our latest manuscript.. Structural basis for hyperpolarization-dependent opening of human HCN1 channel disq.us/t/4p78xec
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Filip Van Petegem@FilipPetegem18 Mar 2024
A postdoc position is available in our lab to study how ion channels communicate with one another. Cryo-EM, electrophysiology, protein biophysics. A great opportunity for structural biologists to learn electrophysiology methods or vice versa. vanpetegemlab.com/opportunit…
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Brannigan Lab@BranniganLab13 Feb 2024
Celebrating another year of successful collaboration with the @WChengLab at the Dandelion. Looking forward to seeing you in LA for #BPS2025!
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Grace Brannigan@GraceBrannigan8 Jan 2024
These simulations of membrane proteins in nanodiscs were so fun. Thank you @WChengLab for your continued enthusiasm for simulations that go beyond the basics - we are lucky computational collaborators! @VikramDalal_37 @PageAnesthesia
Wayland Cheng Lab@WChengLab2 Jan 2024
Our study on nanodiscs and ion channel structure is now published: rdcu.be/duXkK. We hope this will spur more consideration into the impact of nanodiscs on membrane protein structure. @VikramDalal_37 @PageAnesthesia @GraceBrannigan @WUSTL_AnesRsrch
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Vikram Dalal@VikramDalal_372 Jan 2024
It's my pleasure to share that I have been awarded an AHA postdoctoral fellowship. I would like to acknowledge my mentor @WChengLab for unimaginable support, referres: @Pravindrak_IITR, @ShaillyTomar and Alex Evers, and @American_Heart for belief in my proposal. @WChengLab
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This is a very interesting paper showing that nanodiscs, typically used to preserve lipids for structural analysis of membrane proteins, can affect the structure of the target protein. First paper I read this year, happy 2024! nature.com/articles/s41467-0…

Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel

Nature Communications - The authors show that lipid nanodiscs of different scaffold type and size alter the structure of the pentameric ligand-gated ion channel, ELIC. The results suggest that...

nature.com
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Brannigan Lab@BranniganLab13 Nov 2023
🥁Presenting a #namd protocol for SAFEP, the surprisingly straight-forward approach to FEP. Easy to follow tutorial? ✅ Extensive troubleshooting guide? ✅ This project with @jerome_henin 's groups was years in the making! Now at @livecomsj tinyurl.com/yezhr73h
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Sandipan Chowdhury@schow172926 Oct 2023
It’ll be great to have a new postdoc in my group to lead a new project (biochem/biophys/ephys). If there’s anyone out there who wants to chat, message me. I might be a little weird, but the proteins we’re interested in are weirder!
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📢Please RT📢 CIMED is looking to recruit a new tenure-track faculty member doing cryo-EM analyses of membrane proteins. For new or established faculty, and departmental affiliation in Anesthesiology, Biochemistry or Cell Biology, this is a fantastic opportunity! @WUSTL
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Meaghan Creed@Meaghan_Creed10 Jun 2023
We’re hiring! Projects combine genomics, in vivo ephys and synaptic physiology to understand how plasticity in basal ganglia circuits give rise to maladaptive decision making- with a focus on models of substance use disorder and chronic pain! (1/n)
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FAER
@FAERanesthesia1 Jun 2023
Announcing FAER’s approved Spring 2023 Grantees! Join us in congratulating these outstanding physician-investigators & read more on our website! asahq.org/faer/about/news-an… #Anesthesiology #Research #TheFutureIsFAER #FAERgrantees #FAERgrants @AndreaJIbarra
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Rob Gereau@robgereau5 May 2023
3 postdocs landing dream jobs, 1 PhD student graduating means: A)I'm so proud of these amazing scientists and happy for their success & B) We have opportunities to recruit new colleagues!
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K2P channels@K2pChannels26 Feb 2023
Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1 dlvr.it/Sk1M8M
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GrossLab_WashU@GrossLab_WashU3 Mar 2023
We are looking for a new postdoc to join our group. There are several MS-based research opportunities in our group, including membrane proteins, viral proteins, and amyloid-forming proteins. If interested, please see the link below wustl.wd1.myworkdayjobs.com/…
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Paul Riegelhaupt@PRiegelhaupt3 Mar 2023
Please check out new work from my lab, published this week in @NatureComms. Great collaborative work with my @NIGMS K08 mentor @CrinaNimigean and my anesthesiologist/biophysicist buddy @WChengLab. rdcu.be/c6lKa
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Claudia Moreno@Cladoni2 Mar 2023
Forgot to mention at the end of my talk that I’m looking for grad students/postdocs/res scientists curious about how the pacemaker rate adapts. If you are interested let me know!!!
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