Asst Prof @hopkinsheart, by way of @PennMedicine, @SarnoffCardio. Tweets are my own.
Joined December 2018
- Tweets463
- Following284
- Followers1.2K
- Likes2.7K
Virginia Shalkey Hahn, MD retweeted
In Print @JACCJournals JACC: Advances! Our @hopkinsheart #HFpEF Program study of #frailty status, components of frailty, and associated outcomes in ambulatory HFpEF.
Frailty Status Predicts Adverse Outcomes in Ambulatory Heart Failure With Preserved Ejection Fraction | JACC: Advances jacc.org/doi/10.1016/j.jacad…
Kudos to the entire team! @JohnsHopkinsDOM @jhu_coah @jvaishnavmd @vivekpjani @VirginiaSHahnMD
Virginia Shalkey Hahn, MD retweeted
Very excited to share our #multiomics work on the mitochondrial fuel–metabolism signature of #HFpEF myocardium at #AHA25 in NOLA! 🔬🫀@VirginiaSHahnMD
Huge thanks to our chiefs @uclaimchiefs for making this happen @uclaCVfellows @UCLA @hopkinsheart
Fantastic session at #AHA25 on overlaps and opportunities in treating #HFpEF and #CKM @mvaduganathan @hvanspall @KSharmaMD @lamcardio @JavedButler1 @HFpEF
@mvaduganathan highlighted data on the additive effect of nsMRA+SGLT2i, supporting GDMT for #HFpEF
@vinayaksub shared a case illustrating that for pts with #HFpEF, evidence-based💊can dramatically improve quality of life
Virginia Shalkey Hahn, MD retweeted
Single nuclei #RNAseq of human #HFpEF heart biopsies by @VirginiaSHahnMD of @hopkinsheart reveals interesting #macrophage specific changes. Lots of provocative findings!
Virginia Shalkey Hahn, MD retweeted
Proteomic data from HFpEF hearts suggest defects in metabolism and translation, particularly in a more obese subgroup. #AHAJournals @vivekpjani @VirginiaSHahnMD @hopkinsheart ahajrnls.org/4inqJmf
Virginia Shalkey Hahn, MD retweeted
Cardiomyopathies are shaped by more than genetics. Epigenetics & environmental factors play a key role in clinical variability & progression. This review dives into DNA methylation, histone mods, and ncRNAs as therapeutic targets (link.springer.com/article/10…). #HREV @VirginiaSHahnMD
Virginia Shalkey Hahn, MD retweeted
Sex Differences in #Skeletal Muscle Pathology in Patients With Heart Failure and Reduced Ejection Fraction
Muscle biopsies in #HFrEF patients (22 men, 16 women) and controls (18 men, 16 women):
📍5629 differentially expressed genes: men showed increased catabolism, reduced mitochondrial function.
📍Men had higher proatrophic gene expression (ubiquitin proteasome, autophagy), while women had increased IGF1 (proanabolic).
📍Women had more type I muscle fibers, higher capillarity, and pro-oxidative features.
📍Sex differences in HIF1α, ESR1, VEGF, IL-6, and IL-8 expression.
#HFrEF #HeartFailure #SexDifferences #Transcriptomics
@CircHF ahajournals.org/doi/full/10.…
Virginia Shalkey Hahn, MD retweeted
Towards #Metabolomic-Based Precision Approaches for Classifying and Treating #HeartFailure
Personalized approach to metabolomic phenotyping in HF
jacc.org/doi/10.1016/j.jacbt… @JACCJournals @SvatiShah @KSharmaMD
Virginia Shalkey Hahn, MD retweeted
#Metabolomics has the power to identify mechanisms of #HeartFailure & #cardiometabolic disease, & shows promise as biomarkers for #HF diagnosis, prognosis & response to therapy. Innovative approaches using metabolomic technologies will impact precision care for HF bit.ly/4dllvnJ
#JACCBTS @VirginiaSHahnMD @KSharmaMD @senthil_selv @SvatiShah @hopkinsheart
Virginia Shalkey Hahn, MD retweeted
Breaking barriers and leading the way! 🙌Proud to witness in the EP lab this morning: our first female adult EP attending (@NinoIsakadze) & first female chief EP fellow, Keva (@kevagargmd)! 📷#WomenInCardiology
Virginia Shalkey Hahn, MD retweeted
A virtual information session for potential Sarnoff Fellowship medical student applicants will be held on Sunday, October 20, from 4-5 pm, Eastern time. To register for the session, please email [email protected].
Virginia Shalkey Hahn, MD retweeted
Are you an MD student interested in research?
Would strongly consider applying for the @SarnoffCardio Fellowship. Scientific immersion with *unparalleled* longitudinal mentorship & exceptional peer network career-long. sarnofffellowship.com/
My biggest regret in med school was not participating despite guidance from mentors. Now I'm thrilled to join this vibrant community on the Scientific Committee.
Nice summary of the program ahajournals.org/doi/10.1161/… @CircAHA
Track record of successful physician-scientists going through this program is impressive - the recipe of immersion + longitudinal engagement/sponsorship/mentorship works very well
Virginia Shalkey Hahn, MD retweeted
New study finds connection between heart failure and obesity @dkassjhu
hopkinsmedicine.org/news/new…
Happy to share our review "Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure" in @JACCJournals : BTS
Star-studded group with co-first @senthil_selv and co-senior @KSharmaMD and @SvatiShah
doi.org/10.1016/j.jacbts.202…
Congratulations @JLovellMD and @luigiadamomdphd and colleagues! Elegant mechanistic study investigating the role of splenic B cells in chronic heart failure
Tomorrow #preprintHub1 @nicolas_ruffin from @karolinskainst will present a #preprint by @luigiadamomdphd lab showing how B cell-mediated antigen presentation promotes adverse cardiac remodelling in chronic heart failure 🫀🩺👷♀️
biorxiv.org/content/10.1101/…
