@VindigniLab
 Washington University in STL
vindignilab.wustl.edu
Joined December 2019
  • Tweets286
  • Following290
  • Followers1.5K
50Media
What a weekend — thank you, @PedalTheCause! Our hearts are full thanks to the thousands of riders, spinners, donors, sponsors, volunteers and others who gave their all to support @WashUMedicine cancer research at Siteman Cancer Center and Siteman Kids @STLChildrens Hospital. We can’t thank you enough! Together, we are building a world without cancer!
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The Vindigni lab social media is moving to other places! Follow us at @vindignilab.bsky.social
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The Vindigni, Krais and @priyanka13verma labs had an amazing time walking the @STLOvarian 5k this weekend! It was inspiring to connect with the community we hope to serve with our science 💪🏃‍♂️@SitemanCenter @GenomeIntegrity @WashUOncology @washumedicine
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Congrats the @priyanka13verma lab on their recent publication! Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCAmutant cancer cells. Check it out! nature.com/articles/s41467-0…
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Congrats the @abbygreenlab for their recent publication in EMBO- The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress. Check it out! pubmed.ncbi.nlm.nih.gov/3888…

The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress - PubMed

Mutational patterns caused by APOBEC3 cytidine deaminase activity are evident throughout human cancer genomes. In particular, the APOBEC3A family member is a potent genotoxin that causes substantial...

pubmed.ncbi.nlm.nih.gov
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Vindigni lab retweeted
SLU Medicine
@slusom
31 May 2024
Drs. Valerio Rasi, Zach Grese, Jess Bourque, Emily Cybulla , and Meghan Murray 2024 graduates of the MD PhD program. Best Wishes for each of you, your dedication and compassion will make a difference for so many. Congratulations!
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Dr. Alessandro Vindigni @VindigniLab is the Ira Lang Professor of Medicine. Dr. Vindigni is a Professor of Medicine and Pathology & Immunology, Director @GenomeIntegrity @WUSTLmed and Co-leader of the Section of Molecular Oncology @WashUOnc More> internalmedicine.wustl.edu/d…
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Join us on Friday May 24th, for our GMaC Seminar Series to learn more about “Concentration matters: Ribosome function beyond protein synthesis” from Rachel Green, PhD, from Johns Hopkins University, HHMI.
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Join us on Friday April 19th, for our GMaC Seminar Series to learn more about "Replication initiation and genome evolution." from Julian Sale, PhD, from Division of Protein & Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology.
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A huge thank you to CGI Retreat invited speaker Ryan Barnes (University of Kansas Medical Center) and keynote speaker Tanya Paull (University of Texas at Austin) for their amazing talks! So glad you could join us!
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The Vindigni lab had a blast at the 3rd annual CGI retreat at Cedar Creek Lodge! There were exciting talks and posters by trainees from WUSTL and SLU! ⁦@GenomeIntegrity⁩ ⁦@SitemanCenter⁩ ⁦@WUSTLmed⁩ ⁦@WUSTL⁩ ⁦@WashUOnc⁩ ⁦⁩ ⁦@SLU_Official⁩
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Wonderful presentation by ⁦@Seppai99⁩ at CGI retreat on exciting new research on DNA repair in BRCA1-deficiency.⁦@GenomeIntegrity⁩ ⁦@SitemanCenter⁩ ⁦@WUSTLdbbs⁩ ⁦@WashUOnc⁩ ⁦@WUDeptMedicine⁩
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Replying to @GenomeIntegrity
@GenomeIntegrity St. Louis team at the exciting #EMBO DNA repair meeting in my home country #INDIA @VindigniLab thanks @Arnab_RC1 for organizing this wonderful meeting #AmazingSceince #Scenery #Food!!! @WUSTLdbbs @SitemanCenter
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Not only the Science is TOP at the #EMBOdnaDamage in #Lonavala but venue is an oasis and food is incredible !!! And one person made it all possible... Thank you @Arnab_RC1 🙏🙏🙏
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Vindigni lab retweeted
Abby Green@abbygreenlab
13 Feb 2024
My new colleague in the @GenomeIntegrity! Psyched that John joined us in St. Louis!
WashU Medicine Department of Medicine@WashUDeptMed
12 Feb 2024
Please help us welcome John Krais, MD, Assistant Professor of Medicine, @WashUOnc @WUSTLmed Dr. Krais' research interests center on the DNA damage response and how to apply new discoveries to the treatment of cancer. ⁠ Learn more about Dr. Krais > l8r.it/cwau
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.@Meroni_Alice, @sophiewells1007, Fonseca et al. show that DNA combing resolves sister chromatids, allowing the detection of strand-specific alterations, whereas DNA spreading typically does not. hubs.ly/Q02jQq4l0 @VindigniLab @keith_caldecott @Arnab_RC1 #DNABiology
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Out now on JCB a wonderful group driven effort from @keith_caldecott @Arnab_RC1 and @VindigniLab led by @Meroni_Alice @sophiewells1007 and Carmen Fonseca!!! rupress.org/jcb/article/223/…

DNA combing versus DNA spreading and the separation of sister chromatids

DNA combing and DNA spreading are two central approaches for studying DNA replication fork dynamics genome-wide at single-molecule resolution. Meroni et al

rupress.org
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Our paper combined the efforts of three labs to uncover key differences between DNA combining and DNA spreading in sister chromatid detection!!!
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Join us on Friday January 19, for our GMaC Seminar Series to learn more about “Mining for Gold with AlphaFold: Lessons from Genome Maintenance” from Johannes Walter, PhD, from Harvard University and HHMI.
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Happy Holidays from the Vindigni lab! I am so grateful to work with an amazing group of young scientists!!! ⁦@SitemanCenter⁩ ⁦@WUSTLmed⁩
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