@VincentLibis

Research group leader @INSERM - Paris Synbio - microbial natural products - drug discovery

 Paris, France
elis-labs.org/libis/
Joined July 2012
  • Tweets24
  • Following277
  • Followers540
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Interested in heterologous expression of large numbers of biosynthetic gene clusters? My focus over the past years has been to try to make this process more scalable. Have a look at this new approach, I used it to discover a new antibiotic: conkatamycin nature.com/articles/s41467-0…
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🔬 1er lauréat du Prix des #Innovateurs 2024 de la #RégionIDF pour sa méthode de découverte de molécules bioactives d’origine microbienne, découvrez le travail de @VincentLibis, chargé de recherche INSERM au Learning Planet Institute @lpiparis_ de l'@univ_paris_cite ⤵️
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Vincent Libis retweeted
Aude Bernheim@AudeBer6 Sep 2023
So happy about this ! @VincentLibis is an amazing scientist and a great mentor. Join the Paris fun in microbiology and come discover new molecules 🧬💻🇫🇷🍷🥖🧫
Vincent Libis@VincentLibis6 Sep 2023
Replying to @ERC_Research
@ERC_Research is now backing my lab ! We are hiring bright minds at all levels interested in synbio/bioinfo/natural products. Join us in a beautiful space in the heart of Paris & leverage our massive biosynthetic gene cloning platform to discover new antibiotics and more !
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Replying to @ERC_Research
@ERC_Research is now backing my lab ! We are hiring bright minds at all levels interested in synbio/bioinfo/natural products. Join us in a beautiful space in the heart of Paris & leverage our massive biosynthetic gene cloning platform to discover new antibiotics and more !
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Many thanks to the anonymous reviewers, this is quite an honor
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Vincent Libis retweeted
MDMLab@MDMlab_Paris13 Dec 2022
In a new preprint, we report that recently discovered anti-phages systems (Mokosh, Eleos, Lamassu…) have eukaryotic homologs. We harnessed this conservation to discover novel defense mechanisms in humans. @howmanyernest1 @gaofir @EnzoZ_P @AudeBer biorxiv.org/content/10.1101/…

Conservation of antiviral systems across domains of life reveals novel immune mechanisms in humans

Viral infection is a common threat to prokaryotic and eukaryotic life, which has resulted in the evolution of a myriad of antiviral systems. Some of these eukaryotic systems are thought to have...

biorxiv.org
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Need to recover a specific plasmid from a pooled library of clones ? Using a barcoded vector and a dedicated CRISPRi strategy it is now possible to separate the clone of interest from the rest: nature.com/articles/s41587-0… 1st example of application here to recover (meta)genomic BGCs
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Vincent Libis retweeted
Helena Shomar@HelenaShomar8 Sep 2022
My friend, now colleague/collaborator has started a new lab in Paris, on the hottest topic : high throughput cloning and heterologous expression of BGCs I might be biased, but this is what synbio needs. Check it out and come work with us !
Vincent Libis@VincentLibis7 Sep 2022
Replying to @VincentLibis
I just started a lab in Paris developing strategies to manipulate BGCs at a massive scale. DM if you are interested in the platform's capabilities or if you are excited in mixing synbio, bioinformatics and natural products discovery (open positions). A bit on how this started...
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9 yrs ago I joined the Paris iGEM team as a PharmD student. We ended up winning the competition in 2013. Team members included future superstars @AudeBer @SynBio1 @HelenaShomar Today we are once again sharing the same floor, this time as PIs ! same stellar coworkers, same spirit
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We use synthetic biology to mine new drugs from microbial genomes. Aside from the tech, we try to involve the public to help us search for new genes through our citizen science initiative @ScienceALaPelle . People already sent us >1000 soil samples from all over France. More soon
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Vincent Libis retweeted
MDMLab@MDMlab_Paris10 May 2022
Hello world, we are very happy, as the first paper of our new lab has just been published @NatureComms. It’s about describing the anti-viral arsenal of bacteria and a tool we developed to detect all known anti-phage systems called DefenseFinder. nature.com/articles/s41467-0…

Systematic and quantitative view of the antiviral arsenal of prokaryotes

Nature Communications - Bacteria and archaea have developed multiple antiviral mechanisms. Here, Tesson et al. present a tool that automatically detects known antiviral systems in prokaryotic...

nature.com
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Vincent Libis retweeted
Aude Bernheim@AudeBer16 Sep 2020
Stoked to report in @nature the discovery of prokaryotic viperins, which naturally produce diverse anti-viral molecules ! After providing us with antibiotics, bacteria might become sources of novel anti-viral drugs. (1/9) nature.com/articles/s41586-0…
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Biotech needs big transformative change to better serve the public interest. I wrote a furiously radical manifesto about it. Add your name and join me? wintermute.bio/declaration
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Vincent Libis retweeted
Aude Bernheim@AudeBer28 Aug 2019
A great study with smart methods to explore potiental biosynthetic diversity of soils from @VincentLibis. Always cool science from @criparis alumnis! nature.com/articles/s41467-0…

Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis...

Nature Communications - Soil microorganisms are a rich source of bioactive molecules. Here, the authors present a targeted sequencing workflow that reconstructs the clustered organization of...

nature.com
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A vast unexplored biosynthetic potential hides deep inside soil metagenomes. We developed a method to detect rare biosynthetic gene clusters and access their products: nature.com/articles/s41467-0…

Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis...

Nature Communications - Soil microorganisms are a rich source of bioactive molecules. Here, the authors present a targeted sequencing workflow that reconstructs the clustered organization of...

nature.com
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more replies
Interestingly, some of these unknown molecules are very common across the globe. For example one of these can be found in Arizona, Hawaii and Oregon samples, i.e. 3 of the 4 soils we looked at. We expressed its genes in the lab and called the new product Omnipeptin.
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While this targeted approach is far from detecting every biosynthetic gene in the soil, it seems that untargeted (shotgun) sequencing would miss the majority of the gene clusters we report here. If you want to try this approach yourself we would be happy to help.
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Damn it! I had overlooked this super cool 2016 paper by Jean Loup Faulon on how to build biosensors for small molecules that lack transcriptional factors that can recognize them as effectors pubs.acs.org/doi/10.1021/acs…
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Want to expand biosensing abilities via comp-aided design of metabolic pathways? Click here: ow.ly/10pN6O
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