@Velardi_Lab

Our laboratory at the @BambinoGesu Children Hospital in Rome studies mechanisms regulating #immunereconstitution after damage - @AIRC_it @BeTheMatch @ASTCT

 Rome, Italy
velardilab.blogspot.com/
Joined March 2013
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Can we rebuild #thymus function after damage? Our new work shows that targeting proteostasis in TECs regulates #FOXN1 and drives #thymic regeneration. We gratefully acknowledge support from Amy Strelzer Manasevit Research Program, AIRC, Rally Foundation, the Ministry of Health.
CDD press@cddpressMar 27
“Proteasome inhibition promotes Foxn1 expression in thymic epithelial cells and induces thymic regeneration in mice” Read this work from Dr Velardi’s lab: nature.com/articles/s41418-0…
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Open Night at the Bambino Gesù Chidlren Hospital in Rome for the #nottedeiricercatori. Thanks a lot to the people in the lab to have contributed to the event!
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Such a great achievement and an enormous pleasure to have participated in this work. Congrats @Dudakov_Lab and @vandenBrinkLab
Dudakov Lab@Dudakov_Lab7 Aug 2024
With a mix of pride, enthusiasm, and tremendous relief, I present our latest paper that describes the emergence of atypical epithelial cells in the thymus with age that limit the tissues function at steady-state and its repair after damage… 1/? nature.com/articles/s41590-0…

Age-related epithelial defects limit thymic function and regeneration

Nature Immunology - Here the authors identify age-associated changes in the epithelial cell compartment of the thymus that form high-density nonproductive microenvironmental niches that contribute...

nature.com
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Enrico Velardi retweeted
NMDP@nmdp_org24 Jul 2024
As an Amy Scholar, you can research solutions to post-transplant complications that help #celltherapy patients. Apply by Aug. 16 and spread the word to the researchers in your circle 👉 bit.ly/49zF1ve
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Health Consequences of Thymus Removal in Adults | NEJM nejm.org/doi/full/10.1056/NE…

Health Consequences of Thymus Removal in Adults | NEJM

The function of the thymus in human adults is unclear, and routine removal of the thymus is performed in a variety of surgical procedures. We hypothesized that the adult thymus is needed to sustain...

nejm.org
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I am extremely excited to share our study just published in @jacionline. We demonstrate that the human thymus is a target of SARS-CoV-2 and that thymic function is impaired in COVID-19 patients. jacionline.org/article/S0091…

SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity

Lymphopenia, particularly when restricted to the T-cell compartment, has been described as one of the major clinical hallmarks in patients with coronavirus disease 2019 (COVID-19) and proposed as an...

jacionline.org
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My new lab at @MSKCancerCenter is recruiting a postdoc and also a computational biologist to work on #microbiome and cancer #immunotherapy. peledlab.org. Postdoc position linked below. compbio position soon. Please reach out. tinyurl.com/3m6vpxzr
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First in-person meeting after a long time at #siica2022. Congrats to Marco Rosichini and Sara Flamini for the great presentations.
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We are looking for a highly motivated and creative scientist with a strong interest in immunology to join our team at the Bambino Gesù Children Hospital, Rome
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Our review article on thymus function, TCR diversity and patient response to checkpoint blockade immunotherapy is out! frontiersin.org/article/10.3…
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We are seeking for an ambitious & highly motivated POST-DOC. The successful candidate will lead an ongoing effort to investigate the role of autophagy in regulating immune resistance in medulloblastoma with a special focus on NK cell-related therapy!!!
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nature.com/articles/s41467-0…

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Nature Communications - The success of CAR-T cells for treating acute myeloid leukaemia (AML) is hampered by toxicity to normal cells and low CAR-T cell persistence. Here, the authors show that the...

nature.com
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Enrico Velardi retweeted
SIICA Immunologia@SiicaI18 Oct 2021
🔴🔴🔴 SAVE THE DATE Feb 28th - Mar 4th The Virtual School of Immunology 2022 organized by #SIICA. Basic and Advanced course for PhD students, post-doc and MD post-graduate students. Stay tuned for the detailed program and speakers. #immunology #immunity #school #course ⬇️⬇️⬇️
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Excited and proud to share our new paper, published in Acta Neuropathologica. We have identified a combination therapy (autophagy +STAT3 inhibition) to potentially counteract high-risk medulloblastoma link.springer.com/article/10… Thanks to @CecconiLabs @AIRC_it

Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and...

Acta Neuropathologica - Medulloblastoma (MB) is a childhood malignant brain tumour comprising four main subgroups characterized by different genetic alterations and rate of mortality. Among MB...

link.springer.com
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We are seeking a motivated Post-Doc to join our team at the Department of Onco-hematology (Bambino Gesù Pediatric Hospital), Rome. Working on autophagy, immunotherapy and pediatric cancers. For more info:
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📰 New research from @BonfantiLab has used human stem cells and a bioengineered scaffold to rebuild a whole functioning thymus. Read the full story on our website ➡️ ow.ly/Z0Pr50CIIk2 @iit_ucl | @ERC_Research | @NatureComms
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Looking forward to the next Happy Hour with #Immunology
SIICA Immunologia@SiicaI13 Nov 2020
📌 The next Happy Hour with #immunology is scheduled for November 26th at 6 pm: Federica Facciotti & Ivan Monteleone will discuss hot topics in the field of #mucosal immunity. We will taste a glass of wine from Azienda Agricola La Vernetta: have you already chosen your wine? 🍷
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Happy hour with immunology
SIICA Immunologia@SiicaI28 Oct 2020
Don’t miss it! Tomorrow at 6 pm! #BYOW 🍷
Positions available - Grant And Technology Transfer Office ospedalebambinogesu.it/grant…
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Our review article on T cell regeneration after immunological injury is out! @DrMvandenBrink @jjjt_98 @NatRevImmunol
Nature Rev Immunol@NatRevImmunol23 Oct 2020
T cell regeneration after immunological injury dlvr.it/RkCVtd
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