@UciSkin

Official twitter account for UCI skin community. Follow along for updates, events, and the latest in skin research.

 Irvine California USA
skincenter.uci.edu/
Joined March 2023
  • Tweets54
  • Following176
  • Followers73
3Media
nature.com/articles/s41589-0…

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins

Nature Chemical Biology - Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins...

nature.com
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Honored to have our image on the cover of this month’s issue @nchembio featuring the MrTAC paper (linked below)! 🔬🧫
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Excited to share our chemoproteogenomics story now out in its final form in @NatureComms. Congrats to first author Heta Desai @heta_desai17! nature.com/articles/s41467-0…

Chemoproteogenomic stratification of the missense variant cysteinome

Nature Communications - Cancer genomes are rife with genetic variants, and one key outcome of this variation is widespread gain-of-cysteine mutations. Here, the authors pair cysteine...

nature.com
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Hope this will finally move the needle for severe drug reactions like SJS & TEN, nightmare consults in #dermatology. No Rx has great evidence to halt skin/mucosal sloughing that can be fatal. JAKi remains to be rigorously tested in patients/RCT but could change standard of care.
UCISkin@UciSkin16 Oct 2024
Spatial proteomics identifies JAKi as treatment for a lethal skin disease | Nature nature.com/articles/s41586-0…

Spatial proteomics identifies JAKi as treatment for a lethal skin disease

Nature - Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this...

nature.com
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Great work @TheAlbrecht_Lab
Lauren Albrecht@TheAlbrecht_Lab16 Oct 2024
Congratulations to @LJSeabrook and happy to share our latest work!
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Spatial proteomics identifies JAKi as treatment for a lethal skin disease | Nature nature.com/articles/s41586-0…

Spatial proteomics identifies JAKi as treatment for a lethal skin disease

Nature - Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this...

nature.com
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Selective utilization of glucose metabolism guides mammalian gastrulation | Nature nature.com/articles/s41586-0…

Selective utilization of glucose metabolism guides mammalian gastrulation

Nature - Two waves of glucose metabolism provide distinct ERK-mediated cellular signals during gastrulation, which regulate cell fate and specialized cellular functions that are necessary for...

nature.com
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A prenatal skin atlas reveals immune regulation of human skin morphogenesis | Nature nature.com/articles/s41586-0…

A prenatal skin atlas reveals immune regulation of human skin morphogenesis

Nature - A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including...

nature.com
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Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture | Nature Cell Biology nature.com/articles/s41556-0…

Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue...

Nature Cell Biology - Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis...

nature.com
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aquatic skin adaptations evolved independently in hippos and cetaceans! #maksimplikus @CurrentBiology #skin #evolution @UCIrvine @UCIBioSci #johngatsey cell.com/current-biology/ful…
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UCISkin retweeted
NEJM
@NEJM23 Dec 2023
Type VII collagen: A protein encoded by the gene COL7A1. Type VII collagen forms the anchoring fibrils that attach the superficial layer of the skin known as the epidermis to the underlying dermal connective tissue. nej.md/3Nz4Qmq
Visual representation of "type VII collagen"

ALT Visual representation of "type VII collagen"

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Enhanced single RNA imaging revealed dynamic gene expression in live animals. This time-lapse shows mRNA dynamics in the epidermis of C. elegans. #12DaysOfeLife elifesciences.org/articles/8…
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Laurence Seabrook@LJSeabrook8 Sep 2023
Replying to @LJSeabrook
science.org/doi/10.1126/scia…

Vitamin B6 is governed by the local compartmentalization of metabolic enzymes during growth

Lysosomes link Wnt and vitamin B6 metabolism by degrading the rate-limiting B6 enzyme during cell growth and in cancer.

science.org
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How might a recently discovered degron affect metabolism and cancer?🔎🔎🔎 check out our lab’s latest pub!!
This Post is from an account that no longer exists. Learn more
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An unusual rash with dry skin - what’s the diagnosis?
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What you should know about recent advances in safe and effective treatments for #psoriasis. @Practical_Derm spoke to @YaleMed Clinical Professor of Dermatology Bruce Strober, MD, PhD practicaldermatology.com/new…
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Ask the MD: A Skin Test for Parkinson’s | Parkinson's Disease michaeljfox.org/news/ask-md-…

Ask the MD: A Skin Test for Parkinson’s

Shortly after the announcement of a spinal fluid test for Parkinson’s, researchers share results of skin test for the disease, too. Learn about this test, how it compares to that in the spinal fluid,...

michaeljfox.org
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Vitiligo breakthroughs offer hope | UCI Health | Orange County, CA ucihealth.org/blog/2023/06/v…
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Congrats to two of our PhD students for receiving awards for their academic excellence! 🏆 Carolina Faranco received the Excellence in Research Award. Brandon Latifi received the Henry Wood Elliott Graduate Award. Congrats to you both! #UCISPPS @TheAlbrecht_Lab @davidlmobley
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Is There a Baldness Cure? Scalp Regeneration Via Botox-Like Treatment insider.com/hair-loss-cure-s…

Scientists believe they've discovered a cure for baldness. It's hiding in your hairy moles — and...

Scientists at The University of California, Irvine have discovered why some moles grow long hairs. They think the same technique could cure balding.

businessinsider.com
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