Gould Lab studies roles of #BasementMembrane and #ECMatrix, and finds cures of a multi-system disorder #GouldSyndrome caused by mutations in #collagenIV.
UCSF, San Francisco, CA
Joined April 2020
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Gould Lab UCSF retweeted
Thank you for advertising our new preprint, Yutaka! 📢
If you are interested in prolyl 4-hydroxylation and collagen biosynthesis, you can learn how these go in Drosoplia ‼️🪰🪰🪰
Happy Friday 😎
Our preprint is out!
Great collaboration with @yoshihiro0604, @mel_toups, Marwan Elkrewi, Allison Zajac, and @SHBLab
Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV
(13 posts follow) ↓
biorxiv.org/content/10.1101/…
Gould Lab UCSF retweeted
Please add your reading list! Our shiny collagen IV paper is out now😎 Enjoy beautiful red and green images! Yes, I MUST do molecular characterization of this "beauty" collagen IV... My TO-DO list is too much😅
@UCSFGouldLab
Mao et al introduce a novel tagged Col4a1 mouse model for studying basement membrane dynamics, which provides important details of COL4A1 turnover in cerebral vasculature & shows that Col4a1 heterozygous deletion is better tolerated than missense mutations hubs.la/Q03jWjdz0
Gould Lab UCSF retweeted
My first post of 2025 is here! 😎 Excited to share my new paper on horse collagen I 🐎. We explored COL1 structure and modifications in horses with LH1 mutations. Don’t miss the unique images of twisted collagen fibrils—check it out below!👇👇👇
Biochemical characterization of collagen I in Warmblood Fragile Foal Syndrome horse lysyl hydroxylase 1 mutation. #micropublication #biology #data #caltechlibrary # quus caballus #Biochemistry #NewFinding micropublication.org/journal…
Gould Lab UCSF retweeted
Interesting collaboration coming from the @UCSFGouldLab and @TamaraAlliston lab to identify an unexpected role of #collagen type IV in bone biology in connection with #TGFβ bit.ly/3BxKlDy
Gould Lab UCSF retweeted
Want to learn about #GouldSyndrome? Check out this month's featured #CCMBM #MSK member publication from @UCSFGouldLab & @TamaraAlliston: "Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling." sciencedirect.com/science/ar…
Gould Lab UCSF retweeted
Douglas Gould @UCSFGouldLab et al. investigate whether TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage, iovs.arvojournals.org/articl….
Gould Lab UCSF retweeted
We are please to announce Drs. Yoshi Ishikawa @yoshihiro0604 and Masashi Yanagisawa as the Luncheon Seminar speakers at #JSMBM24. 日本結合組織学会大会のランチョンセミナーはUCSF のYoshi Ishikawa 先生によるコラーゲンのフォールディング、Masashi Yanagisawa 先生による睡眠の講演です！
Gould Lab UCSF retweeted
What an incredible first day at the #Alportworkshop on #WorldKidneyDay - so much has happened in the last 10 years & always so good to catch up with #basementmembrane friends ❤️@JeffMinerPhD @UCSFGouldLab @SherwoodElegans @stramerlab
Gould Lab UCSF retweeted
Looking for another exciting #ECMatrix conference before our biennial meeting? Check out the #Collagen #GordonConference, where our very own ASMB council member Doug Gould @UCSFGouldLab is vice-chair! 👇
grc.org/collagen-conference/…
Gould Lab UCSF retweeted
We need to understand the mechanisms of disease due to #COL4A1_4A2 to develop treatments. A #rare_disease affecting many tissues that informs on common diseases, including #stroke, and fundamental biology. #collagen #matrixbiology @UofGICAMS @GouldSyndrome @UCSFGouldLab ,