Retinal Phenotyping Research Group based @UCLeye / @MoorfieldsBRC . Performing Adaptive Optics imaging since 2013.
London, England
Joined August 2017
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Without any doubt, THE highlight of our team's work over the last 10 years, using handheld OCT to objectively document outer retina structure. It may be a small part compared to our AOSLO work, but transformative for patients and their families.
Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study hubs.li/Q037K8wJ0
ALT Research in context panel for "Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study". Copyright: 2024 The Author(s). Published by Elsevier Ltd. CC BY 4.0.
UCL Retinal Phenotyping retweeted
From astronomy-inspired eye imaging to stepping inside a Camera Obscura, explore the science of sight at the Bloomsbury Festival's Discovery Hub.
22 Oct & 23 Oct: 3 – 4 pm
Sat 24 Oct: 11 am - 4 pm
Where: Holborn Library
🔗 buff.ly/xCyhxRb
UCL Retinal Phenotyping retweeted
Our Bloomsbury Festival exhibition in Russell Square is up! Researchers at the @UCLeye are showing you the eye as you've never seen it before. Come and see for yourself before the end of October.
The love heart is actually a mini-retina, grown in a dish using patient stem cells!
ALT A row of exhibition panels mounted on black railings along a city pavement. The nearest panel displays NIHR Biomedical Research Centre and Moorfields branding, alongside information about eye health research and the Bloomsbury Festival. Adjacent panels feature colourful microscopic images of eye tissue and research exhibits.
ALT This image shows retinal organoids which are tiny mini‑retinas grown ‘in a dish’ from a patient’s stem cells. They allow researchers to see how retinal cells develop and behave, study eye diseases and test new treatments in a safe, controlled way.
ALT This image uses technology to show the many cell types found in human retinal tissue to identify the structure and relationships between the immune and nervous system.
UCL Retinal Phenotyping retweeted
Johnny Tam et al. from the National Eye Institute @NatEyeInstitute establish an in vivo database of human cone photoreceptor inner segment diameter evaluated across the lifespan.
doi.org/10.1167/iovs.67.10.4…
UCL Retinal Phenotyping retweeted
🧬 BREAKTHROUGH: IOB researchers have identified a new genetic cause of inherited blindness in previously unexplored regions of the genome.
Published today in @NatureGenet
🧵Thread ⬇️
UCL Retinal Phenotyping retweeted
We are happy to launch our latest Annual Review, highlighting our achievements during the 2024-2025 academic year. You can access the full content on our website: ucl.ac.uk/brain-sciences/ioo…
UCL Retinal Phenotyping retweeted
As 2025 draws to a close, join us in reflecting on some of the incredible breakthroughs from the Faculty this year!
👁️ In February, a procedure developed by researchers from @UCLeye gave infants life-changing improvements in sight.
ucl.ac.uk/news/2025/feb/gene…
ALT Genetic therapy gives infants life-changing improvements in sight
Analysis of familial exudative vitreoretinopathy (FEVR) cases in the UK 100 000 genomes project increases diagnostic rate and implicates heterozygous CTNND1 mutations in FEVR - go.shr.lc/4jvu4AY
UCL Retinal Phenotyping retweeted
Nikolas Pontikos et al. @UCLeye investigate combining information retrieval with text generation using Retrieval-Augmented Generation to benchmark the performance of open-source and proprietary generative LLMs in question-answering in ophthalmology.
doi.org/10.1167/tvst.14.9.18
UCL Retinal Phenotyping retweeted
Review article by Alexis Ceecee Britten-Jones et al. from The University of Melbourne provides an update on the recent progress in the diagnosis, management, and treatments for Stargardt disease.
doi.org/10.1167/tvst.14.9.26
UCL Retinal Phenotyping retweeted
Michel Michaelides et al. from Moorfields Eye Hospital @UCLeye describe the largest cohort of RHO-associated retinitis pigmentosa (RP) to date, analyzing the spectrum of phenotypes, variants, disease natural history, and genotype-phenotype correlations.
doi.org/10.1167/iovs.66.9.69
UCL Retinal Phenotyping retweeted
Omar Mahroo et al. @UCLeye explore Discrepancies Between Autofluorescence Imaging Modalities in CNGB3-Associated Achromatopsia and Correlation With Ellipsoid Zone Continuity, tvst.arvojournals.org/articl….
UCL Retinal Phenotyping retweeted
Excited to see advancements in retinal research for X-linked retinitis pigmentosa. The community urges Johnson & Johnson to seek approval for its XLRP gene therapy, offering hope to patients. fightingblindness.org/news/r… @MichelMichaelid @UCL_Retina
UCL Retinal Phenotyping retweeted
Allison Ayala et al. share their Functional Vision Assessment Over 4 Years in USH2A Using the Veteran Affairs Low-Vision Visual Functioning Questionnaire, iovs.arvojournals.org/articl….
@JaebCenter @UMKelloggEye @UCSF @FightBlindness @MassEyeAndEar @UCLeye @BCMDeptMedicine
UCL Retinal Phenotyping retweeted
Image of the Week: Milky Way Spiral
Milky Way dust emission as measured from the Planck satellite and converted into a polarization pattern of B-modes, a spiral type of polarization imprinted in the microwave sky.
Read more here: bit.ly/3Uj2QCf
#Milkyway #emission
UCL Retinal Phenotyping retweeted
Stop by my poster B0500 today at #ARVO2025 to see high-resolution AOSLO retinal imaging in Tyr gene-edited 13-lined ground squirrels and learn more about the germline inheritance of their mutations! Grateful for my support from @MCW_CBNA, @MCW_GSA and @NatEyeInstitute
UCL Retinal Phenotyping retweeted
Michel Michaelides et al. study the Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation, tvst.arvojournals.org/articl….
@ucl_retina @UCLeye @Moorfields
UCL Retinal Phenotyping retweeted
Michel Michaelides et al. provide Detailed Clinical, Ophthalmic, and Genetic Characterization of MYO7A-Associated Usher Syndrome, iovs.arvojournals.org/articl….
@Moorfields @UCLeye @UCL_Retina
UCL Retinal Phenotyping retweeted
Great to hear our Deputy Director Professor Alison Hardcastle in the video of the launch event of a new Centre of Excellence for eye health in Warsaw. Funded by @HorizonEU, this is a strategic partnership between @UCLeye, @ICTER_PL & @InstVisionParis.
ucl.ac.uk/ioo/news/2025/mar/…
UCL Retinal Phenotyping retweeted
In the latest Eye on the Cure podcast, Professor Michel Michaelides, a leading clinical researcher at Moorfields Eye Hospital and University College London, joins host Ben Shaberman to discuss groundbreaking advancements in gene therapy.
Hear about the extraordinary vision improvements seen in young children receiving treatment for Leber congenital amaurosis 4 (LCA4), as well as promising therapies in clinical trials for X-linked retinitis pigmentosa and Stargardt disease.
🎧 Don’t miss this exciting conversation—listen now. bit.ly/41TdL8S
UCL Retinal Phenotyping retweeted
Ivana Mihalek et al. present their work Quantifying the Progression of Stargardt Disease in Double-Null ABCA4 Carriers Using Fundus Autofluorescence Imaging, tvst.arvojournals.org/articl….
