@TyphiPapers
Joined March 2022
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  • Followers21
Typhi genomics papers retweeted
Megan Carey@meganecarey11 Oct 2022
Preprint 🚨 - our phylogenetic + phylodynamic analyses suggest H58 𝘚. Typhi emerged in the late 1980s in India, likely from a chronic carrier, and was already MDR. tinyurl.com/originh58 – at Amsterdam, The Netherlands
Maximum likelihood phylogenetic tree featuring a global collection of Salmonella Typhi isolated between 1980 and 1995. The long branch length separating early H58 isolates from nearest neighbors is indicated with an arrow. Genotype is indicated by branch color, and country of origin, presence of MDR, and presence of QRDR mutations are indicated by ring color, and colored per inset legend.

ALT Maximum likelihood phylogenetic tree featuring a global collection of Salmonella Typhi isolated between 1980 and 1995. The long branch length separating early H58 isolates from nearest neighbors is indicated with an arrow. Genotype is indicated by branch color, and country of origin, presence of MDR, and presence of QRDR mutations are indicated by ring color, and colored per inset legend.

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Typhi genomics papers retweeted
Michael Sikorski@mckorki12 Sep 2022
🚨Pub on the genomics of typhoid in Samoa. A culmination of 4 years and an incredible trans-Pacific collab incl. @SamoaGovt @UMCVD @GenomeScience @TheDohertyInst, et al. Special thanks to @RaskoDavid and Mike Levine! @TyphiPapers @TyphiNET @PreventTyphoid journals.asm.org/doi/10.1128…

Persistence of Rare Salmonella Typhi Genotypes Susceptible to First-Line Antibiotics in the Remote...

In this study, we used whole genome sequencing and comparative genomics analyses to characterize the population structure, evolutionary origins, and genomic features of S. Typhi associated with...

journals.asm.org
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Typhi genomics papers retweeted
Iruka Okeke@iruka_okeke7 Sep 2022
We're very proud to publish our initial learnings and findings from this effort in @PLOSNTDs. This is a collaborative effort among @NCDCgov @GHRUamr and Nigeria's AMR sentinels journals.plos.org/plosntds/a… .../6

Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria

Author summary Whole genome sequencing of 63 invasive Salmonella from 5 tertiary hospitals in Nigeria revealed multiple serovars including a dominant antibiotic-resistance-gene harbouring S. Typhi...

journals.plos.org
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Typhi genomics papers retweeted
Iruka Okeke@iruka_okeke7 Sep 2022
If you want to understand the epidemiology of typhoid in an endemic area, it helps to undertake regular and in-depth analysis of strains - made relatively easy by genomic methods. Trouble is, that in many endemic areas, there are not a lot of strains.../2
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Population structure and evolution of Salmonella enterica serotype Typhi in Zimbabwe before a typhoid conjugate vaccine immunization campaign biorxiv.org/content/10.1101/…

Population structure and evolution of Salmonella enterica serotype Typhi in Zimbabwe before a...

Background The continued emergence of Salmonella enterica serovar Typhi ( S . Typhi) with ever increasing antimicrobial resistance (AMR), necessitates the use of vaccines in endemic countries. A...

biorxiv.org
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Typhi genomics papers retweeted
Michael Sikorski@mckorki29 Aug 2022
🚨New #typhoid #genomics paper finds multiple introductions of H58/4.3.1 S. Typhi into Kibera. @TyphiPapers @TyphiNET @PreventTyphoid #PLOSNTDs: Molecular characterization of circulating Salmonella Typhi strains in an urban informal settlement ... dx.plos.org/10.1371/journal.…
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#PLOSNTDs: Whole genome sequence analysis of Salmonella Typhi provides evidence of phylogenetic linkage betwe ... dx.plos.org/10.1371/journal.…

Whole genome sequence analysis of Salmonella Typhi provides evidence of phylogenetic linkage...

Author summary Studies of Salmonella Typhi (the cause of typhoid fever) rarely include isolates collected both before and after the interruption of hyperendemic transmission because this typically...

journals.plos.org
The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study thelancet.com/journals/lanmi…

The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella...

Independent acquisition of plasmids and homoplastic mutations conferring antimicrobial resistance have occurred repeatedly in multiple lineages of S Typhi, predominantly arising in south Asia before...

thelancet.com
Genomic epidemiology of Salmonella Typhi in Central Division, Fiji, 2012 to 2016 thelancet.com/journals/lanwp…

Genomic epidemiology of Salmonella Typhi in Central Division, Fiji, 2012 to 2016

Cyclones and flooding drove ‘waves’ of typhoid outbreaks in Fiji which, through population aggregation, poor sanitation and water safety, and then mobility of the population, spread clones more...

thelancet.com
Genomic analysis unveils the role of genome degradation events and gene flux in the emergence and persistence of S. Paratyphi A lineages biorxiv.org/content/10.1101/…

Genomic analysis unveils the role of genome degradation events and gene flux in the emergence and...

Paratyphoid fever caused by S . Paratyphi A is endemic in parts of Asia and Sub-Saharan Africa. The proportion of enteric fever cases caused by S . Paratyphi A has substantially increased, yet only...

biorxiv.org
Impact of Salmonella genome rearrangement on gene expression biorxiv.org/content/10.1101/…
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Antimicrobial Susceptibility and Genomic profiling of Salmonella enter... sciencedirect.com/science/ar…
Distinct Potentially Adaptive Accumulation of Truncation Mutations in Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi A | Microbiology Spectrum journals.asm.org/doi/10.1128…

Distinct Potentially Adaptive Accumulation of Truncation Mutations in Salmonella enterica serovar...

Detecting the adaptive mutations leading to gene inactivation or loss of function is crucial for understanding their contribution in the evolution of bacterial virulence and antibiotic resistance....

journals.asm.org
#PLOSNTDs: Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established popu ... dx.plos.org/10.1371/journal.…
Extensively Drug-Resistant (XDR) Salmonella Typhi Outbreak by Waterborne Infection — Beijing Municipality, China, January–February 2022 weekly.chinacdc.cn/en/articl…

Extensively Drug-Resistant (XDR) Salmonella Typhi Outbreak by Waterborne Infection — Beijing...

weekly.chinacdc.cn
Persistence of rare Salmonella Typhi genotypes susceptible to first-line antibiotics in the remote islands of Samoa medrxiv.org/content/10.1101/…

Persistence of rare Salmonella Typhi genotypes susceptible to first-line antibiotics in the remote...

For decades, the remote island nation of Samoa (pop. ~200,000) has faced endemic typhoid fever despite improvements in water quality, sanitation, and economic development. We recently described the...

medrxiv.org
The burden of typhoid fever in sub-Saharan Africa | RRTM @DovePress dovepress.com/the-burden-of-…

The burden of typhoid fever in sub-Saharan Africa | RRTM | Dove Medical Press

While typhoid fever has largely been eliminated in high-income regions that have developed sanitation this disease remains a public health burden.

dovepress.com
Genomic Investigation Reveals a Community Typhoid Outbreak Caused by Contaminated Drinking Water in China, 2022 frontiersin.org/article/10.3…

Frontiers | Genomic Investigation Reveals a Community Typhoid Outbreak Caused by Contaminated...

Typhoid fever is a life-threatening disease caused by Salmonella enterica serovar Typhi (S. Typhi) and remains a significant public health burden in developi...

frontiersin.org
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