rdcu.be/fh2br Ascites promotes peritoneal metastasis of ovarian cancer by protecting against ferroptosis
nature.com/articles/s41467-0…
Jen-Tsan Ashley Chi retweeted
Ascites in ovarian cancer may do more than cause symptoms.
Duke researchers found it helps cancer cells evade ferroptosis. A cholesterol drug may help disrupt this protection in certain conditions.
@dukeobgyn
medschool.duke.edu/news/comm…
Jen-Tsan Ashley Chi retweeted
jci.org/articles/view/202212 New in JCI: We identify MESH1 as a coenzyme A phosphatase that controls ferroptosis sensitivity and muscle health.
Knocking down MESH1 preserves CoA, protects mitochondria from lipid peroxidation, and rescues muscle atrophy in flies.
Jen-Tsan Ashley Chi retweeted
Researchers have identified MESH1, an enzyme that helps explain why many people with cancer lose muscle during treatment.
The findings point to a potential pathway for future therapies to preserve strength and mobility during cancer care and aging.
medschool.duke.edu/news/hidd…
jci.org/articles/view/202212 New in JCI: We identify MESH1 as a coenzyme A phosphatase that controls ferroptosis sensitivity and muscle health.
Knocking down MESH1 preserves CoA, protects mitochondria from lipid peroxidation, and rescues muscle atrophy in flies.
Jen-Tsan Ashley Chi retweeted
Jen‑Tsan Ashley Chi, Pei Zhou, and Matthew J. Hilton led a Duke University School of Medicine study identifying MESH1 as a key regulator of cellular sulfation, with implications for bone and cartilage health.
medschool.duke.edu/news/duke…
MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation | Nature Chemical Biology nature.com/articles/s41589-0…
Identification of 4,5,6,7-Tetrabromo-1H-benzotriazole (TBB) as a Small Molecule MESH1 Inhibitor that Suppresses Ferroptosis biorxiv.org/content/10.64898…
Our JCI study reveals that Coenzyme A defends against #ferroptosis by CoAlating mitochondrial TXNRD2. NBIA and other CoA-defective diseases show vulnerability to ferroptosis, offering a new path to therapy.
jci.org/articles/view/190215
Our new review paper on MESH1 and its striking similarities with bacterial SpoT and stringent response.
#PLOSPathogens: From magic spot ppGpp to MESH1: Stringent response from bacteria to metazoa dx.plos.org/10.1371/journal.…
@DukeMGM. Some striking similarities here.
[THREAD]
Similarity #3. MESH1 removal, like stringent response, also triggers proliferation arrests and nucleotide depletion. Great work by Alice Sun and @ckcding
nature.com/articles/s41419-0…
But all through distinct substrates. With the help of Josh Rose in Pei Zhou lab, we have found that the relevant substrate of human MESH1 is NADPH. This is an excellent example of phenotypic conservation through distinct biochemical activities.
nature.com/articles/s42255-0…
Congratulations on such an exciting work.
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congrats to @KotasMaya and @RnaHelix - two @UCSF #physicianscientists (and WPSS members) selected for the 2022 Burroughs Wellcome Fund Career Awards for Medical Scientists!! 🥂 #bwfcams @UCSFPath @UCSFMedicine @UCSFPCCMFellows congrats to all of the awardees!
Jen-Tsan Ashley Chi retweeted
Our featured publication investigates the effects a low-carb diet could have on patients with prostate cancer: ow.ly/2mqo50IC1Ss
Jen-Tsan Ashley Chi retweeted
Our newest featured publication highlights work from @TsanJen, Simon Gregory & team on gene expression regulation and heterogeneity among red blood cells: ow.ly/yfkT50J6mlq
@DukeMGM