@TroRom

Research fellow at the Department of Chemical Sciences of the University of Naples Federico II

 Napoli
Joined November 2011
  • Tweets32
  • Following720
  • Followers72
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I'm happy to share our work, recently published in @MolTherapy Here, we show that anti-thrombin aptamers can target both thrombin and prothrombin, providing insights into their recognition mechanism cell.com/molecular-therapy-f… @DscUnina @UninaIT @DiamondLightSou @SLU_Official

Prothrombin recognition and conformational modulation by anti-thrombin anticoagulant aptamers

Anti-thrombin anticoagulant aptamers act as dual-targeting agents by recognizing both thrombin and its precursor, prothrombin. Biophysical and structural analyses reveal a similar recognition...

cell.com
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Prothrombin recognition and conformational modulation by anti-thrombin anticoagulant aptamers dlvr.it/TTgxb6 #genetherapy #celltherapy

Prothrombin recognition and conformational modulation by anti-thrombin anticoagulant aptamers

Anti-thrombin anticoagulant aptamers act as dual-targeting agents by recognizing both thrombin and its precursor, prothrombin. Biophysical and structural analyses reveal a similar recognition...

cell.com
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Romualdo Troisi retweeted
Chemistry Europe@ChemEuropeApr 15
#ChemBioChem @TroRom and coworkers (at @DscUnina @UninaIT @HelmholtzMunich @CNRsocial_) uncover how the catalytic domain of human CDC25B binds 3-O-methylfluorescein phosphate #OpenAccess doi.org/10.1002/cbic.2026000…

The Binding of 3‐O‐Methylfluorescein Phosphate to the Catalytic Domain of the Human CDC25B Phosph...

Structural studies on the complex that CDC25B C473S (CDC25B-S) forms with the 3-O-methylfluorescein phosphate (3-OMFP) reveal how the fluorogenic substrate binds CDC25B-S, engaging key binding...

chemistry-europe.onlinelibrary.wiley.com
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Structural studies on CDC25B phosphatase in complex with 3-OMFP reveal how the ligand binds within the active site, engaging key regions and inducing conformational changes that stabilize the protein. @UninaIT @CNRsocial_ @HelmholtzMunich dx.doi.org/10.1002/cbic.2026…

The Binding of 3‐O‐Methylfluorescein Phosphate to the Catalytic Domain of the Human CDC25B Phosph...

Structural studies on the complex that CDC25B C473S (CDC25B-S) forms with the 3-O-methylfluorescein phosphate (3-OMFP) reveal how the fluorogenic substrate binds CDC25B-S, engaging key binding...

chemistry-europe.onlinelibrary.wiley.com
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The X-ray structure of the adduct formed upon reaction of aurothiomalate with apo-transferrin: gold binding sites and a unique transferrin structure along the apo/holo transition pathway @InorgChemFront #MNESYS #PNRR @esrfsynchrotron @DscUnina pubs.rsc.org/en/Content/Arti…

The X-ray structure of the adduct formed upon reaction of aurothiomalate with apo-transferrin: gold...

The interaction of sodium aurothiomalate with the apo form of human serum transferrin (hTF) was studied by X-ray crystallography. The protein binds gold io

pubs.rsc.org
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Investigating the structural effects of anti-thrombin anticoagulant aptamers on activation of human prothrombin biorxiv.org/content/10.1101/… #Preprint @biorxivpreprint #Coagulation #Anticoagulant #Aptamer #BiophysicalAnalysis

Investigating the Structural Effects of Anti-Thrombin Anticoagulant Aptamers on Activation of Human...

Disorders of the blood coagulation remain a leading cause of death and disability worldwide raising the search for therapeutic agents able to modulate the coagulation cascade. Different oligonucleo...

biorxiv.org
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The structure of the cisplatin adduct of the apo human serum transferrin (hTF) was solved and compared with that formed by the drug when hTF binds Fe(III) at the C-lobe only. @InorgChem @ACSPublications #MNESYS #PNRR @esrfsynchrotron @DscUnina pubs.acs.org/doi/10.1021/acs…

Cisplatin/Apo-Transferrin Adduct: X‑ray Structure and Binding to the Transferrin Receptor 1

Abstract. Here, we report the X-ray structure of the adduct formed upon reaction of cisplatin, one of the most prescribed anticancer agents for the clinic

pubs.acs.org
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Romualdo Troisi retweeted
SCI Giovani@SciGiovani20 Sep 2024
🏅PREMIO PRIMO LEVI 2023: i finalisti!🏅 Ultimo ma non per importanza, chiudiamo la rassegna con @TroRom da @UninaIT con il suo articolo candidato al #PremioLevi2023 Video: youtu.be/dnhD3lJmiZ4
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🔬 New Insights into G-Quadruplexes and Protein Interactions G4s can bind selectively to target proteins, and their structural versatility suggests new approaches for medical treatments. Illustrations made using #protienimager The paper doi.org/10.1016/j.sbi.2024.1…
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Our latest review "Structural overview of DNA and RNA G-quadruplexes in their interaction with proteins" is online on #CurrentOpinionInStructuralBiology SI: Protein Nucleic Acid Interactions (2024) @DscUnina @CNRsocial_ @COSB_CRSB doi.org/10.1016/j.sbi.2024.1…
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In our paper now on @DaltonTrans, crystallographic studies reveal that, in the AP-1/DNA systems, the Pt–As bond can break down with time. @DscUnina @CNRsocial_ pubs.rsc.org/en/content/arti…

On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer†

The reaction of Pt-based anticancer agents with arsenic trioxide affords robust complexes known as arsenoplatins. The prototype of this family of anticance

pubs.rsc.org
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Romualdo Troisi retweeted
RPTH@RPTHjournal25 Dec 2023
Number 5⃣ of the RPTH Top 10 of 2023. This #RPTHIllustratedreview is a great way to introduce the coagulation cascade to trainees. And it features some of the cutest coagulation factors we've ever seen! 🩸rpthjournal.org/article/S247…
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Our review "Structural Insights into Protein–Aptamer Recognitions Emerged from Experimental and Computational Studies" is now online on @IJMS_MDPI mdpi.com/2560232 #mdpiijms @DscUnina @CNRsocial_

Structural Insights into Protein–Aptamer Recognitions Emerged from Experimental and Computational...

Aptamers are synthetic nucleic acids that are developed to target with high affinity and specificity chemical entities ranging from single ions to macromolecules and present a wide range of chemical...

mdpi.com
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Romualdo Troisi retweeted
DscUnina@DscUnina2 Oct 2023
Gli studi strutturali sull'aptamero M08s-1 guadagnano la copertina di NAR! Info: scienzechimiche.unina.it/avv…
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Romualdo Troisi retweeted
RPTH@RPTHjournal18 Sep 2023
Are you responsible for teaching the #coagulation cascade? Check out this incredible new #RPTHIllustratedReview for great visuals & the newest insights from experimental and computational studies! bit.ly/3ECoOb7
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How an illustrated review should look like! Scientists from the University of Naples just published a review on the structural aspects of the coagulation cascade and it is gorgeousssss! Fantastic illustrations made with #proteinimager, check them out: rpthjournal.org/article/S247…
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After hard but inspiring work, our totally illustrated review has been published in @RPTHjournal This simple format helps us to deliver the atomic-level knowledge about the blood coagulation to a broad readership. @CNRsocial_ @DscUnina @proteinimaging sciencedirect.com/science/ar…
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I am very delighted to share our latest research article published in @NAR_Open The discussed results have been achieved thanks to the fruitful collaboration among @UninaIT @DscUnina @UTokyo_News_en and @HelmholtzMunich doi.org/10.1093/nar/gkad634
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The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at atomic level is still unclear. Here, you can find the first X-ray structure of the adduct formed upon reaction of hTF with cisplatin: pubs.acs.org/doi/10.1021/acs… @InorgChem @DscUnina @UninaIT

Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study

Abstract. The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molec

pubs.acs.org
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A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers Check it out on #MolecularTherapyNucleicAcids cell.com/molecular-therapy-f… @DscUnina @UninaIT @elettrasincro

A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoag...

End-functionalization with phosphodiester-linked donor-acceptor groups provides novel properties to TBA aptamer. In particular, a comprehensive crystallographic analysis reveals for the first time a...

cell.com
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